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PreprintCited by 21Mitochondrial Function and PathologyProtein Structure and DynamicsLipid Membrane Structure and Behavior

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An integrative modelling approach to the mitochondrial cristae

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Brown, Chelsea M., Westendorp, Marieke S. S., Zarmiento-Garcia, Rubi, Stevens, Jan A., Rouse, Sarah L., Marrink, Siewert J., Wassenaar, Tsjerk A.·2024·Communications Biology
DOI 10.1101/2024.09.23.613389PMC PMC12216777

Preprint — published as 10.1038/s42003-025-08381-5

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Abstract

Mitochondria are implicated in many cellular functions such as energy production and apoptosis but also disease pathogenesis. To effectively perform these roles, the mitochondrial inner membrane has invaginations known as cristae that dramatically increase the surface area. This works to provide more space for membrane proteins that are essential to the roles of mitochondria. While separate components of this have been studied computationally, it remains a challenge to combine elements into an overall model. Here we present a workflow to create a comprehensive model of a crista junction from a human mitochondrion. Our coarse-grained representation of a crista shows how various experimentally determined features of organelles can be combined with molecular modelling to give insights into the interactions and dynamics of complicated biological systems. This work is presented as an initial ‘living’ model for this system, intended to be built upon and improved as our understanding, methodology and resources develop.

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Metadata

Authors
Brown, C. M., Westendorp, M. S. S., Zarmiento-Garcia, R., Stevens, J. A., Rouse, S. L., Marrink, S. J., & Wassenaar, T. A.
Affiliations
  • University of Groningen (NL)
  • Imperial College London (GB)
Corresponding author
Wassenaar, Tsjerk A.
ORCID
Venue
Communications Biology
Publisher
openRxiv
Published
2024-09-23
Volume
8
Issue
1
Pages
972-972
ISSN
2399-3642 (ISSN-L)
DOI
10.1101/2024.09.23.613389
PMC
PMC12216777
OpenAlex
W4411977788
Cited by
21
References
1
Citations by year
2026: 15 · 2025: 6
FWCI
6.31
Type
journal article
Language
en
Open access
Licence
Locations
  • Communications Biology (publishedVersion, cc-by-nc-nd)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, cc-by-nc-nd)
  • Spiral (Imperial College London) (submittedVersion, cc-by-nc-nd)
Funders
  • UK Research and Innovation
  • Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWA.1292.19.170)
  • Medical Research Council (MR/Y01975X/1)
  • HORIZON EUROPE European Research Council (101053661)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
Keywords
mitochondrial cristae, inner mitochondrial membrane, coarse-grained models, membrane protein interactions, mitochondrial dynamics, integrative modeling, human mitochondria
MeSH terms
Humans, Mitochondria, Models, Molecular, Mitochondrial Proteins, Mitochondrial Membranes

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