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Genetic mapping in Collaborative Cross mouse strains identifies loci that affect initial sensitivity to cocaine

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Schoenrock, SA, Gaines, CH, Kumar, P, Khan, S, Farrington, J, Ferris, MT, Pardo-Manuel de Villena, F, Valdar, W, Bubier, JA, Tarantino, LM·2025·Psychopharmacology
DOI 10.1101/2025.01.12.629464

Preprint — published as 10.1007/s00213-025-06901-z

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Abstract

We identified two Collaborative Cross (CC) strains, CC004/TauUncJ (CC004) and CC041/TauUncJ (CC041), that differ significantly for locomotor response and self-administration of cocaine. In the current study, we crossed each of these strains to C57BL/6NJ (B6N) mice to produce two F2 populations and identify genetic loci that influence locomotor response to cocaine. We identified three significant loci on chromosomes 7, 11 and 14 in the CC041 F2 mapping cross that collectively explain 14% of the phenotypic variance for locomotor response to cocaine. We used a bioinformatic approach to identify high quality candidate genes that are genetically plausible, have functional relevance and are suitable for further exploration. Our study is the first to use CC strains to perform QTL mapping for addiction-related phenotypes and proposes several candidate genes for follow-up analyses.

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Research works printed but not linked: 82

  1. 10.1111/adb.13162 · DOI
  2. 10.1101/gr.278157.123 · DOI
  3. 10.1038/nn1598 · DOI
  4. Blanchard, M. W. , J. S. Sigmon , J. Brennan , C. Ahulamibe , M. E. Allen , S. Ardery , R. S. Baric , T. A. Bell , J. Farrington , D. Ciavatta , M. C. Cruz Cisneros , M. Drushal , M. T. Ferris , R. C. Fry , C. Gaines , B. Gu , M. T. Heise , P. Hock , R. A. Hodges , M. Hulgin , T. Kafri , R. M. Lynch , T. Magnuson , D. R. Miller , C. E. Y. Murphy , D. T. Nguyen , K. E. Noll , M. K. Proulx , C. M. Sassetti , S. A. Schoenrock , G. D. Shaw , J. M. Simon , C. M. Smith , M. Styblo , L. M. Tarantino , J. Woo and F. Pardo Manuel de Villena (2024). “The updated mouse universal genotyping array bioinformatic pipeline improves genetic QC in laboratory mice.” G3 (Bethesda) 14(10). · DOI
  5. 10.1097/00008571-200104000-00009 · DOI
  6. 10.1007/s00213-009-1656-7 · DOI
  7. Broman, K. W . (2014). “Fourteen Years of R/qtl: Just Barely Sustainable.” J Open Res Softw 2(1). · DOI
  8. Broman, K. W. and S. Sen (2009). A Guide to QTL Mapping with R/qtl. New York, Springer Sciences. · DOI
  9. 10.1093/bioinformatics/btg112 · DOI
  10. 10.3389/fnins.2020.00721 · DOI
  11. 10.1073/pnas.0306880101 · DOI
  12. 10.1038/s41386-021-01031-4 · DOI
  13. 10.1016/j.drugalcdep.2020.108148 · DOI
  14. 10.1074/jbc.M000040200 · DOI
  15. 10.1523/JNEUROSCI.3909-08.2008 · DOI
  16. 10.1038/ng1104-1133 · DOI
  17. 10.1111/j.1460-9568.2011.07811.x · DOI · Paper page
  18. 10.1038/s41380-019-0546-6 · DOI
  19. 10.1016/j.neubiorev.2012.04.005 · DOI
  20. 10.1007/s00213-015-4147-z · DOI · Paper page
  21. 10.1016/j.psc.2012.03.010 · DOI · Paper page
  22. 10.1093/genetics/151.1.373 · DOI
  23. 10.1007/s13311-019-00777-6 · DOI
  24. 10.1073/pnas.0812530106 · DOI · Paper page
  25. 10.1038/nn.3976 · DOI
  26. 10.1016/j.ceca.2016.02.001 · DOI
  27. 2005, Genomewide linkage scan for cocaine dependence and related traits: significant linkages for a cocaine-related trait and cocaine-induced paranoia, Am J Med Genet B Neuropsychiatr Genet, 136B, 45, 10.1002/ajmg.b.30189 · DOI
  28. 10.1038/mp.2013.99 · DOI
  29. 10.1097/00008571-200306000-00004 · DOI
  30. 10.1111/j.1601-183X.2008.00422.x · DOI
  31. 10.1038/nrg1635 · DOI · Paper page
  32. 10.1126/science.2218493 · DOI
  33. 10.1128/mBio.00493-15 · DOI
  34. 10.1371/journal.pgen.1005504 · DOI
  35. 10.1016/j.ceca.2009.12.002 · DOI
  36. 10.1093/oxfordjournals.jhered.a111088 · DOI
  37. 10.1016/j.brainres.2009.10.013 · DOI
  38. 10.1038/sj.emboj.7600038 · DOI
  39. 10.1016/j.drugalcdep.2017.08.031 · DOI
  40. 10.1097/00008571-199910000-00007 · DOI
  41. 10.3390/cells8010010 · DOI
  42. 10.1038/s41588-018-0309-3 · DOI · Paper page
  43. 10.1042/AN20120095 · DOI
  44. 10.1176/appi.ajp.21090892 · DOI
  45. 10.1016/j.ajhg.2018.11.008 · DOI · Paper page
  46. 10.1016/j.ceca.2015.11.002 · DOI
  47. 10.1152/physrev.00041.2018 · DOI
  48. 10.1073/pnas.1016088108 · DOI · Paper page
  49. 10.1038/s41467-019-11916-0 · DOI
  50. 10.1126/science.1245503 · DOI · Paper page
  51. 10.1002/syn.20935 · DOI
  52. 10.1111/j.1471-4159.2010.07010.x · DOI
  53. 10.1254/jphs.11106FP · DOI
  54. 10.1159/000493941 · DOI
  55. 10.1038/s41588-018-0307-5 · DOI · Paper page
  56. 10.1007/BF02246541 · DOI
  57. 2015, argyle: An R Package for Analysis of Illumina Genotyping Arrays, G3 (Bethesda), 6, 281
  58. 10.1534/g3.115.022087 · DOI · Paper page
  59. 2017, Editor’s Highlight: Candidate Risk Factors and Mechanisms for Tolvaptan-Induced Liver Injury Are Identified Using a Collaborative Cross Approach, Toxicol Sci, 156, 438
  60. 10.1002/humu.20925 · DOI
  61. 10.1523/JNEUROSCI.18-08-03023.1998 · DOI · Paper page
  62. 10.1126/science.1259595 · DOI · Paper page
  63. 10.1038/s41586-022-05477-4 · DOI
  64. 10.1007/s00213-019-05429-3 · DOI
  65. 10.1371/journal.pone.0035367 · DOI
  66. 10.1038/msb.2011.75 · DOI
  67. 10.1534/genetics.120.303596 · DOI
  68. 10.1093/nar/gks539 · DOI
  69. 10.1093/NAR/GKAC1010 · DOI · Paper page
  70. 10.1534/genetics.116.198838 · DOI
  71. 10.1192/bjp.bp.115.161950 · DOI
  72. 1994, Genetic analysis of sensitization and tolerance to cocaine, J Pharmacol Exp Ther, 270, 1230, 10.1016/S0022-3565(25)22532-0 · DOI
  73. 10.1093/NAR/GKAC1052 · DOI · Paper page
  74. 10.1016/j.drugalcdep.2020.108185 · DOI
  75. 10.1126/sciadv.abj9446 · DOI
  76. 10.1038/mp.2013.159 · DOI
  77. 10.1111/add.16229 · DOI
  78. 10.1038/s41467-020-18489-3 · DOI
  79. 10.1186/s12916-023-02945-0 · DOI
  80. 10.1038/s41593-020-0643-5 · DOI
  81. 10.1089/ars.2010.3359 · DOI
  82. 10.1073/pnas.0912126106 · DOI

Metadata

Authors
Schoenrock, S., Gaines, C., Kumar, P., Khan, S., Farrington, J., Ferris, M., Pardo-Manuel de Villena, F., Valdar, W., Bubier, J., & Tarantino, L.
Affiliations
  • University of North Carolina at Chapel Hill;
  • University of North Carolina at Chapel Hill (US)
  • The Jackson Laboratory
ORCID
Venue
Psychopharmacology
Publisher
openRxiv
Published
2025-01-12
Volume
243
Issue
6
Pages
1471-1488
ISSN
0033-3158 (ISSN-L)
DOI
10.1101/2025.01.12.629464
OpenAlex
W4415566528
Cited by
1
References
2
Citations by year
2026: 1
FWCI
0.39
Type
journal article
Language
en
Open access
Licence
Locations
  • Psychopharmacology (publishedVersion, cc-by)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
  • PubMed (publishedVersion)
  • Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion, cc-by)
  • UNC Libraries
Funders
  • National Institutes of Health
  • National Institute of Mental Health (R01MH100241)
  • National Institute on Drug Abuse (R01DA023690, P50DA039841)
  • National Institute of General Medical Sciences (R35GM127000)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords
cocaine dependence, cocaine sensitivity, gene mapping, cocaine self-administration, candidate genes, psychostimulants
MeSH terms
Collaborative Cross Mice, Animals, Chromosome Mapping, Cocaine, Female, Male, Mice, Inbred C57BL, Motor Activity, Self Administration, Species Specificity, Cocaine-Related Disorders, Mice, Genetic Loci

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