Localization of Genes Mediating Acute and Sensitized Locomotor Responses to Cocaine in BXD/Ty Recombinant Inbred Mice
Open accessAbstract
Sensitization to the psychostimulant effects of cocaine has received widespread attention because concomitant changes occur in neurochemical pathways that are part of the brain reward pathway. The current study was undertaken with the purpose of mapping genes determining sensitivity to the acute stimulant and sensitizing effects of cocaine. Sensitivity and sensitization to cocaine (5, 10, and 40 mg/kg) were measured in 25 BXD/Ty recombinant inbred (BXD RI) strains and the progenitor C57BL/6J (B6) and DBA/2J (D2) strains. Quantitative trait locus (QTL) mapping provisionally localized cocaine sensitivity genes to regions on all chromosomes except 6, 11, 17, and X; sensitization QTLs were localized to chromosomes 1–10, 13, 15, 18, 19, and X. Provisional QTLs for locomotion after saline injection in a novel setting were mapped to chromosomes 1, 3–6, 9, 12, 13, 18, and 19 and in a familiar setting to chromosomes 4–7, 9, 13, and 19. There were both common and unique QTL regions across the phenotypes. Evidence for a genetic association between magnitude of acute cocaine response and sensitization was obtained for only the 10 mg/kg dose. Some common QTL regions for cocaine, ethanol, and methamphetamine responses suggest the possibility that these drugs induce stimulant effects or sensitization through some common mechanisms. However, independent mechanisms were also indicated. Many candidate genes reside near the provisional QTLs mapped for cocaine responses, including genes coding a variety of neurotransmitter and hormone receptors. These data, once confirmed, should prove useful for directing investigations of acute and chronic cocaine effects down already suspected and novel avenues.
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The genetic variation in acute responsiveness to drugs is different to that responsible for differences in sensitization.
“There is also evidence suggesting that the genetic variation in acute responsiveness to drugs is different to that responsible for differences in sensitization (Eisener-Dorman, Grabowski-Boase, & Tarantino, 2011; Phillips, Huson, & McKinnon, 1998; Phillips, Huson, Gwiazdon, Kasch, & Shen, 1995).”
From Cued for Risk: Evidence for an Incentive Sensitization Framework to Explain the Interplay between Stress and Anxiety, Substance Abuse, and Reward Uncertainty in Disordered Gambling Behavior (2019) · cites this paper as Phillips, Huson, & McKinnon, 1998
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Cites
Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results
Lander, E. S., & Kruglyak, L. (1995) · Nature Genetics · doi:10.1038/ng1195-241 · Cited by 5,196 · see citing works
Genetic Dissection of Complex Traits
Lander, E. S., & Schork, N. J. (1994) · Science · doi:10.1126/science.8091226 · Cited by 3,425 · see citing works
Robinson, T. G., & BECKER, J. (1986) · Brain Research · doi:10.1016/s0006-8993(86)80193-7 · Cited by 2,110 · see citing works
Robinson, T. E., & Becker, J. B. (1986) · Brain Research Reviews · doi:10.1016/0165-0173(86)90002-0 · Cited by 1,796 · see citing works
Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptors
Baik, J., Picetti, R., Saiardi, A., Thiriet, G., Dierich, A., Depaulis, A., LeMeur, M., & Borrelli, E. (1995) · Nature · doi:10.1038/377424a0 · Cited by 651 · see citing works
Pierce, R. C., Bell, K., Duffy, P., & Kalivas, P. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-04-01550.1996 · Cited by 624 · see citing works
Hope, B. T., Nye, H. E., Kelz, M. B., Self, D. W., Iadarola, M. J., Nakabeppu, Y., Duman, R. S., & Nestler, E. J. (1994) · Neuron · doi:10.1016/0896-6273(94)90061-2 · Cited by 563 · see citing works
Effect of acute and daily cocaine treatment on extracellular dopamine in the nucleus accumbens
Kalivas, P. W., & Duffy, P. (1990) · Synapse · doi:10.1002/syn.890050104 · Cited by 544 · see citing works
A Macintosh program for storage and analysis of experimental genetic mapping data
Manly, K. F. (1993) · Mammalian Genome · doi:10.1007/bf00357089 · Cited by 502 · see citing works
Mice Lacking Dopamine D4 Receptors Are Supersensitive to Ethanol, Cocaine, and Methamphetamine
Rubinstein, M., Phillips, T. J., Bunzow, J. R., Falzone, T. L., Dziewczapolski, G., Zhang, G., Fang, Y., Larson, J. L., McDougall, J. A., Chester, J. A., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80365-7 · Cited by 473 · see citing works
Self-citationKelly, M. A., Rubinstein, M., Phillips, T. J., Lessov, C. N., Burkhart‐Kasch, S., Zhang, G., Bunzow, J. R., Fang, Y., Gerhardt, G. A., Grandy, D. K., et al. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-09-03470.1998 · Cited by 447 · see citing works
Self-citationGenetic Animal Models of Alcohol and Drug Abuse
Crabbe, J. C., Belknap, J. K., & Buck, K. J. (1994) · Science · doi:10.1126/science.8209252 · Cited by 419 · see citing works
Localization of Genes Affecting Alcohol Drinking in Mice
Phillips, T. J., Crabbe, J. C., Metten, P., & Belknap, J. K. (1994) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1994.tb00062.x · Cited by 291 · see citing works
Self-citationQuantitative Trait Loci Involved in Genetic Predisposition to Acute Alcohol Withdrawal in Mice
Buck, K. J., Metten, P., Belknap, J. K., & Crabbe, J. C. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-10-03946.1997 · Cited by 269 · see citing works
Sensitization to cocaine stimulation in mice
Shuster, L., Yu, G., & Bates, A. (1977) · Psychopharmacology · doi:10.1007/bf00439108 · Cited by 256 · see citing works
Wolf, M. E., & Jeziorski, M. C. (1993) · Brain Research · doi:10.1016/0006-8993(93)90913-8 · Cited by 243 · see citing works
Bonci, A., & Williams, J. T. (1996) · Neuron · doi:10.1016/s0896-6273(00)80082-3 · Cited by 228 · see citing works
Henry, D., & White, F. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-09-06287.1995 · Cited by 223 · see citing works
THE EFFECT OF REPEATED DOSES OF COCAINE ON THE RAT
Downs, A. W., & Eddy, N. B. (1932) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)07982-0 · Cited by 219 · see citing works
Cunningham, C. L. (1995) · Psychopharmacology · doi:10.1007/bf02246142 · Cited by 209 · see citing works
Neurochemical Bases of Locomotion and Ethanol Stimulant Effects
Phillips, T. J., & Shent, E. H. (1996) · International review of neurobiology · doi:10.1016/s0074-7742(08)60669-8 · Cited by 208 · see citing works
Self-citationPhillips, T. J., Huson, M., Gwiazdon, C., Burkhart‐Kasch, S., & Shen, E. H. (1995) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.1995.tb01502.x · Cited by 205 · see citing works
Self-citationBadiani, A., Browman, K. E., & Robinson, T. E. (1995) · Brain Research · doi:10.1016/0006-8993(95)00028-o · Cited by 204 · see citing works
Sensitization to the behavioral effects of cocaine: Modification by Pavlovian conditioning
Hinson, R. E., & Poulos, C. X. (1981) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(81)90208-2 · Cited by 194 · see citing works
Reith, M. E. A., Benuck, M., & Lajtha, Á. (1987) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)39232-3 · Cited by 193 · see citing works
Parsons, L. H., & Justice, J. B. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb09794.x · Cited by 190 · see citing works
Mapping Quantitative Trait Loci for Open-Field Behavior in Mice
Gershenfeld, H. K., Neumann, P. E., Mathis, C., Crawley, J. N., Li, X., & Paul, S. M. (1997) · Behavior Genetics · doi:10.1023/a:1025653812535 · Cited by 189 · see citing works
Berrettini, W. H., Ferraro, T. N., Alexander, R. C., Buchberg, A. M., & Vogel, W. H. (1994) · Nature Genetics · doi:10.1038/ng0594-54 · Cited by 183 · see citing works
Segal, D. S., & Kuczenski, R. T. (1992) · Brain Research · doi:10.1016/0006-8993(92)90297-m · Cited by 181 · see citing works
Weiss, S. R. B., Post, R. M., Pert, A., Woodward, R., & Murman, D. (1989) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(89)80001-2 · Cited by 180 · see citing works
Melo, J. A., Shendure, J., Pociask, K., & Silver, L. M. (1996) · Nature Genetics · doi:10.1038/ng0696-147 · Cited by 177 · see citing works
Use of recombinant inbred strains to identify quantitative trait loci in psychopharmacology
Gora-Maslak, G., McClearn, G. E., Crabbe, J. C., et al. (1991) · Psychopharmacology · doi:10.1007/bf02245643 · Cited by 171 · see citing works
Differences in the Pharmacokinetics of Cocaine in Naive and Cocaine‐Experienced Rats
Pan, H., Menacherry, S. D., & Justice, J. B. (1991) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1991.tb11425.x · Cited by 165 · see citing works
Heidbreder, C. A., Thompson, A. C., & Shippenberg, T. S. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)20628-0 · Cited by 163 · see citing works
Behavioral sensitization to drug stimulant effects in C57BL/6J and DBA/2J inbred mice.
Phillips, T. J., Dickinson, S. D., & Burkhart‐Kasch, S. (1994) · Behavioral Neuroscience · doi:10.1037//0735-7044.108.4.789 · Cited by 161 · see citing works
Self-citationBelknap, J. K., Mitchell, S. R., O’Toole, L. A., Helms, M. L., & Crabbe, J. C. (1996) · Behavior Genetics · doi:10.1007/bf02359892 · Cited by 161 · see citing works
Pharmacokinetics of systemically administered cocaine and locomotor stimulation in mice.
Benuck, M., Lajtha, Á., & Reith, M. E. A. (1987) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)39211-6 · Cited by 152 · see citing works
Shippenberg, T. S., LeFevour, A., & Heidbreder, C. A. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12305-7 · Cited by 151 · see citing works
Unterwald, E. M., Ho, A., Rubenfeld, J. M., & Kreek, M. J. (1994) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)22549-6 · Cited by 149 · see citing works
Behavioral sensitization to drug stimulant effects in C57BL/6J and DBA/2J inbred mice.
Phillips, T. J., Dickinson, S. D., & Burkhart‐Kasch, S. (1994) · Behavioral Neuroscience · doi:10.1037/0735-7044.108.4.789 · Cited by 146 · see citing works
Self-citationShort-Term Selective Breeding as a Tool for QTL Mapping: Ethanol Preference Drinking in Mice
Belknap, J. K., Richards, S. P., O’Toole, L. A., Helms, M. L., & Phillips, T. J. (1997) · Behavior Genetics · doi:10.1023/a:1025615409383 · Cited by 142 · see citing works
Self-citationRodriguez, L. A., Plomin, R. J., Blizard, D. A., et al. (1995) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1995.tb01517.x · Cited by 135 · see citing works
EXPERIMENTAL COCAINE ADDICTION
Tatum, A. L., & Seevers, M. H. (1929) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)04092-3 · Cited by 135 · see citing works
Genetic Relationships Between Inbred Strains of Mice
Taylor, B. A. (1972) · Journal of Heredity · doi:10.1093/oxfordjournals.jhered.a108235 · Cited by 129 · see citing works
Behavioral sensitization to cocaine: modulation by the cyclic AMP system in the nucleus accumbens
Miserendino, M. J. D., & Nestler, E. J. (1995) · Brain Research · doi:10.1016/0006-8993(95)00030-t · Cited by 118 · see citing works
Goeders, N. E., & Kuhar, M. J. (1987) · PubMed · Cited by 108 · see citing works
Alcohol Acceptance, Preference, and Sensitivity in Mice.
Rodriguez, L. A., Plomin, R. J., Blizard, D. A., et al. (1994) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1994.tb01444.x · Cited by 108 · see citing works
Ortiz, J., DeCarpio, J. L., Kosten, T. A., & Nestler, E. J. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00018-e · Cited by 107 · see citing works
Confirmation of quantitative trait loci for ethanol sensitivity in long-sleep and short-sleep mice.Preprint
Markel, P. D., Bennett, B., Beeson, M., et al. (1997) · Genome Research · doi:10.1101/gr.7.2.92 · Cited by 105 · see citing works
Sex differences in sensitization to cocaine-induced rotation
Glick, S. D., & Hinds, P. A. (1984) · European Journal of Pharmacology · doi:10.1016/0014-2999(84)90442-4 · Cited by 102 · see citing works
Belknap, J. K., Mogil, J. S., Helms, M. L., Richards, S. P., O’Toole, L. A., Bergeson, S. E., & Buck, K. J. (1995) · Life Sciences · doi:10.1016/0024-3205(95)02040-p · Cited by 101 · see citing works
Modulation of drug-induced sensitization processes by endogenous opioid systems
Spanagel, R. (1995) · Behavioural Brain Research · doi:10.1016/0166-4328(94)00176-g · Cited by 98 · see citing works
Belknap, J. K., Metten, P., Helms, M. L., et al. (1993) · Behavior Genetics · doi:10.1007/bf01067426 · Cited by 94 · see citing works
Critical role for glucocorticoid receptors in stress- and ethanol-induced locomotor sensitization.
Roberts, A. J., Lessov, C. N., & Phillips, T. J. (1995) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12130-7 · Cited by 92 · see citing works
Self-citationDevelopment of behavioral sensitization to cocaine: influence of kappa opioid receptor agonists.
Heidbreder, C. A., Babovic‐Vuksanovic, D., Shoaib, M., et al. (1995) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12030-2 · Cited by 90 · see citing works
Robustness of G protein changes in cocaine sensitization shown with immunoblotting
Striplin, C. D., & Kalivas, P. W. (1993) · Synapse · doi:10.1002/syn.890140103 · Cited by 85 · see citing works
Mapping quantitative trait loci for behavioral traits in the mouse
Johnson, T. E., DeFries, J. C., & Markel, P. D. (1992) · Behavior Genetics · doi:10.1007/bf01066635 · Cited by 82 · see citing works
Crabbe, J. C., Belknap, J. K., Mitchell, S. R., et al. (1994) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)38681-7 · Cited by 79 · see citing works
Genetic analysis of sensitization and tolerance to cocaine.
Tolliver, B. K., Belknap, J. K., Woods, W. E., et al. (1994) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)22532-0 · Cited by 78 · see citing works
Quantitative Trait Loci Affecting Methamphetamine Responses in BXD Recombinant Inbred Mouse Strains
Grisel, J. E., Belknap, J. K., O’Toole, L. A., Helms, M. L., Wenger, C. D., & Crabbe, J. C. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-02-00745.1997 · Cited by 77 · see citing works
Gallaher, E. J., Jones, G. E., Belknap, J. K., et al. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12913-3 · Cited by 76 · see citing works
Phillips, T. J., Lessov, C. N., Harland, R. D., et al. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12914-5 · Cited by 67 · see citing works
Self-citationKoff, J. M., Shuster, L., & Miller, L. G. (1994) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)38476-4 · Cited by 65 · see citing works
Mayfield, R. D., Larson, G. A., & Zahniser, N. R. (1992) · Brain Research · doi:10.1016/0006-8993(92)90783-6 · Cited by 62 · see citing works
Neumann, P. E., & Seyfried, T. N. (1990) · Behavior Genetics · doi:10.1007/bf01067798 · Cited by 61 · see citing works
Hooks, M. S., Jones, G. H., Hemby, S. E., et al. (1993) · Psychopharmacology · doi:10.1007/bf02257416 · Cited by 57 · see citing works
Crabbe, J. C., Phillips, T. J., Gallaher, E. J., et al. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12915-7 · Cited by 57 · see citing works
Self-citationBelknap, J. K. (1992) · Behavior Genetics · doi:10.1007/bf01066638 · Cited by 54 · see citing works
Inference in linkage analysis of multifactorial traits using recombinant inbred strains of mice
Neumann, P. E. (1992) · Behavior Genetics · doi:10.1007/bf01066637 · Cited by 52 · see citing works
The role of the nucleus accumbens in sensitization to drugs of abuse
Steketee, J. D., Sorg, B. A., & Kalivas, P. W. (1992) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(92)90075-p · Cited by 45 · see citing works
IPPOLIT SOKOLOV AND THE GYMNASTICS OF LABOR
BOWLT, J. E. (1996) · Experiment · doi:10.1163/2211730x96x00216 · Cited by 43 · see citing works
Chromosomal mapping of the psychomotor stimulant effects of cocaine in BXD recombinant inbred mice
Miner, L. L., & Marley, R. J. (1995) · Psychopharmacology · doi:10.1007/bf02246541 · Cited by 42 · see citing works
Alexander, R. (1996) · Neuropsychopharmacology · doi:10.1016/s0893-133x(96)00058-9 · Cited by 42 · see citing works
Ida, I., Asami, T., & Kuribara, H. (1995) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.69.83 · Cited by 40 · see citing works
Boulay, D., Duterte‐Boucher, D., Leroux‐Nicollet, I., Naudon, L., & Costentin, J. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)20139-2 · Cited by 38 · see citing works
Wenger, G. R. (1989) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(89)90240-2 · Cited by 34 · see citing works
Tolliver, B. K., Ho, L. B., Reid, M. S., & Berger, S. P. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)20149-5 · Cited by 31 · see citing works
Moore, T. O., June, H. L., & Lewis, M. J. (1993) · Alcohol · doi:10.1016/0741-8329(93)90078-3 · Cited by 28 · see citing works
Reid, M. S., Hsu, K., Tolliver, B. K., et al. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12402-6 · Cited by 27 · see citing works
Morrow, B. A., Taylor, J. R., & Roth, R. H. (1995) · Brain Research · doi:10.1016/0006-8993(94)01456-r · Cited by 27 · see citing works
Acute sensitivity vs. context-specific sensitization to cocaine as a function of genotype
Elmer, G. I., Gorelick, D. A., Goldberg, S. R., et al. (1996) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(95)02062-4 · Cited by 25 · see citing works
Quock, R. M., Mueller, J. L., Vaughn, L. K., et al. (1996) · Brain Research · doi:10.1016/0006-8993(96)00211-9 · Cited by 23 · see citing works
Miner, L. L., & Marley, R. J. (1995) · Psychopharmacology · doi:10.1007/bf02245099 · Cited by 22 · see citing works
Williams, J. E., Wieczorek, W. J., Willner, P., et al. (1995) · Brain Research · doi:10.1016/0006-8993(95)00188-v · Cited by 22 · see citing works
Orona, R. A., Mayfield, R. D., Cline, E. J., et al. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)91042-1 · Cited by 19 · see citing works
Isaki, L. (1995) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1995.tb01463.x · Cited by 16 · see citing works
Thomas, W. L., Cooke, E. S., & Hammer, R. P. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)20141-0 · Cited by 14 · see citing works
Isel, F., & Mandel, P. (1989) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(89)90404-8 · Cited by 7 · see citing works
The distribution of [11C]cocaine in normal and cocaine-sensitization mice
Mizugaki, M., Hishinuma, T., Kimura, K., et al. (1994) · Nuclear Medicine and Biology · doi:10.1016/0969-8051(94)90158-9 · Cited by 6 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Silver L M, Nadeau JH (1997) Mammalian genome, Vol 7. New York: Springer.
Cited by
Sorted by citations
Hellberg, S. N., Russell, T. I., & Robinson, M. J. F. (2019) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/s13415-018-00662-3 · Cited by 65 · see citing works
Cocaine locomotor activation, sensitization and place preference in six inbred strains of mice
Eisener-Dorman, A. F., Grabowski-Boase, L., & Tarantino, L. M. (2011) · Behavioral and Brain Functions · doi:10.1186/1744-9081-7-29 · Cited by 62 · see citing works
- Authors
- Phillips, T. J., Huson, M. G., & McKinnon, C. S.
- Affiliations
- Oregon Health & Science University (US)
- ORCID
- Phillips, Tamara J.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1998-04-15
- Volume
- 18
- Issue
- 8
- Pages
- 3023-3034
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6792576
- OpenAlex
- W1614699707
- Cited by
- 96
- References
- 89
- Citations by year
- 2025: 1 · 2022: 6 · 2021: 3 · 2020: 1 · 2019: 1 · 2018: 1 · 2016: 1 · 2015: 2 · 2014: 5 · 2013: 4 · 2012: 6
- FWCI
- 1.84
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Veterans Affairs
- National Institute on Alcohol Abuse and Alcoholism (P60AA010760)
- National Institute on Drug Abuse
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- cocaine sensitization, locomotor activity, quantitative trait loci, gene mapping, candidate genes, neurotransmitter receptors, psychostimulants, methamphetamine, brain reward system
- MeSH terms
- Ethanol, Animals, Association Learning, Behavior, Animal, Central Nervous System Depressants, Cocaine, Conditioning, Psychological, Female, Genetic Markers, Locomotion, Male, Mice, Inbred C57BL, Mice, Inbred DBA, Recombinant Proteins, Dopamine Uptake Inhibitors, Quantitative Trait, Heritable, Mice
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