The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
p53 Regulation of Metabolic Pathways
Open accessAbstract
During the course of tumorigenesis, cells acquire a number of alterations that contribute to the acquisition of the malignant phenotype, allowing them to survive and flourish in increasingly hostile environments. Cancer cells can be characterized by perturbations in the control of cell proliferation and growth, resistance to death, and alterations in their interactions with the microenvironment. Underpinning many of these changes are shifts in metabolism that allow cancer cells to use alternative pathways for energy production and building the macromolecules necessary for growth, as well as regulating the generation of signaling molecules such as reactive oxygen species (ROS). In the past few years, it became clear that p53, the most studied, if not most important, tumor suppressor protein, can also directly control metabolic traits of cells.
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Citations
Cites
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Backgroundp53 Regulates Mitochondrial Respiration
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Cited by
Tumor Suppression in the Absence of p53-Mediated Cell-Cycle Arrest, Apoptosis, and Senescence
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2-Deoxy-D-glucose targeting of glucose metabolism in cancer cells as a potential therapy
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p53 Research: The Past Thirty Years and the Next Thirty Years
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Traumatic Brain Injury: Oxidative Stress and Neuroprotection
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Metadata
- Authors
- Gottlieb, E., & Vousden, K. H.
- Venue
- Cold Spring Harbor Perspectives in Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2009-12-02
- Volume
- 2
- Issue
- 4
- Pages
- a001040-a001040
- ISSN
- 1943-0264 (ISSN-L)
- OpenAlex
- W2123016912
- Cited by
- 178
- References
- 18
- Type
- posted content
- Language
- en
- Open access
- bronze
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