The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
The Nuclear Factor NF- B Pathway in Inflammation
Open accessAbstract
The nuclear factor NF-kappaB pathway has long been considered a prototypical proinflammatory signaling pathway, largely based on the role of NF-kappaB in the expression of proinflammatory genes including cytokines, chemokines, and adhesion molecules. In this article, we describe how genetic evidence in mice has revealed complex roles for the NF-kappaB in inflammation that suggest both pro- and anti-inflammatory roles for this pathway. NF-kappaB has long been considered the "holy grail" as a target for new anti-inflammatory drugs; however, these recent studies suggest this pathway may prove a difficult target in the treatment of chronic disease. In this article, we discuss the role of NF-kappaB in inflammation in light of these recent studies.
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Cites
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NF-κB: a key role in inflammatory diseases
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“Re-educating” tumor-associated macrophages by targeting NF-κB
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Self-citation
Cited by
NF-κB signaling in inflammation
Liu, T., Zhang, L., Joo, D., & Sun, S.-C. (2017) · Signal Transduction and Targeted Therapy · doi:10.1038/sigtrans.2017.23 · Cited by 8,791
NF-κB, the first quarter-century: remarkable progress and outstanding questions
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The Klotho proteins in health and disease
Kuro-o, M. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-018-0078-3 · Cited by 707
Kaempferol and inflammation: from chemistry to medicine
Devi, K. P., Malar, D. S., Nabavi, S. F., Sureda, A., Xiao, J., Nabavi, S. M., & Daglia, M. (2015) · Pharmacological Research · doi:10.1016/j.phrs.2015.05.002 · Cited by 619
Metadata
- Authors
- Lawrence, T.
- Venue
- Cold Spring Harbor Perspectives in Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2009-10-07
- Volume
- 1
- Issue
- 6
- Pages
- a001651-a001651
- ISSN
- 1943-0264 (ISSN-L)
- OpenAlex
- W2135919238
- Cited by
- 4,898
- References
- 7
- Type
- posted content
- Language
- en
- Open access
- bronze
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