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The Nuclear Factor NF- B Pathway in Inflammation
Open accessAbstract
The nuclear factor NF-kappaB pathway has long been considered a prototypical proinflammatory signaling pathway, largely based on the role of NF-kappaB in the expression of proinflammatory genes including cytokines, chemokines, and adhesion molecules. In this article, we describe how genetic evidence in mice has revealed complex roles for the NF-kappaB in inflammation that suggest both pro- and anti-inflammatory roles for this pathway. NF-kappaB has long been considered the "holy grail" as a target for new anti-inflammatory drugs; however, these recent studies suggest this pathway may prove a difficult target in the treatment of chronic disease. In this article, we discuss the role of NF-kappaB in inflammation in light of these recent studies.
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Metadata
- Authors
- Lawrence, T.
- Venue
- Cold Spring Harbor Perspectives in Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2009-10-07
- Volume
- 1
- Issue
- 6
- Pages
- a001651-a001651
- ISSN
- 1943-0264 (ISSN-L)
- OpenAlex
- W2135919238
- Cited by
- 4,898
- References
- 7
- Type
- posted content
- Language
- en
- Open access
- bronze
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