The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Wnt Signaling from Development to Disease: Insights from Model Systems
Open accessAbstract
One of the early surprises in the study of cell adhesion was the discovery that beta-catenin plays dual roles, serving as an essential component of cadherin-based cell-cell adherens junctions and also serving as the key regulated effector of the Wnt signaling pathway. Here, we review our current model of Wnt signaling and discuss how recent work using model organisms has advanced our understanding of the roles Wnt signaling plays in both normal development and in disease. These data help flesh out the mechanisms of signaling from the membrane to the nucleus, revealing new protein players and providing novel information about known components of the pathway.
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Citations
Cites
Wnt proteins are lipid-modified and can act as stem cell growth factors
Willert, K., Brown, J. D., Danenberg, E., Duncan, A. W., Weissman, I. L., Reya, T., Yates, J. R., & Nusse, R. (2003) · Nature · doi:10.1038/nature01611 · Cited by 2,257
Veeman, M. T., Axelrod, J. D., & Moon, R. T. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00266-1 · Cited by 1,359
Wnt Signaling: Multiple Pathways, Multiple Receptors, and Multiple Transcription Factors
Gordon, M. D., & Nusse, R. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.r600015200 · Cited by 1,333
Heterochromatin and Epigenetic Control of Gene Expression
Grewal, S. I. S., & Moazed, D. (2003) · Science · doi:10.1126/science.1086887 · Cited by 1,065
Mao, J., Wang, J., Liu, B., Pan, W., Farr, G. H., Flynn, C., Yuan, H., Takada, S., Kimelman, D., Li, L., et al. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00224-6 · Cited by 839 · cited 1×
“Wnt stimulation or LRP overexpression decrease Axin protein levels in several systems (Kofron et al. 2007; Mao et al. 2001; Tolwinski et al. 2003), which should compromise the destruction complex.”
BackgroundThe developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity
Wallingford, J. B., & Habas, R. (2005) · Development · doi:10.1242/dev.02068 · Cited by 509
Wg/Wnt Signal Can Be Transmitted through Arrow/LRP5,6 and Axin Independently of Zw3/Gsk3β Activity
Tolwinski, N. S., Wehrli, M., Rives, A., Erdeniz, N., DiNardo, S., & Wieschaus, E. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00063-7 · Cited by 286 · cited 3×
“Wieschaus’ laboratory found that Wnt signaling alters Axin stability, thus regulating its cytoplasmic anchoring function (Tolwinski et al. 2003).”
BackgroundXing, Y., Clements, W. K., Kimelman, D., & Xu, W. (2003) · Genes & Development · doi:10.1101/gad.1142603 · Cited by 237 · cited 1×
“The Weis and Xu laboratories examined affinities of bcat for both APC and Axin (Choi et al. 2006; Ha et al. 2004; Liu et al. 2006; Xing et al. 2003).”
BackgroundWnt family proteins are secreted and associated with the cell surface.
Smolich, B. D., McMahon, J. A., McMahon, A. P., & Papkoff, J. (1993) · Molecular Biology of the Cell · doi:10.1091/mbc.4.12.1267 · Cited by 172
Grohmann, A., Tanneberger, K., Alzner, A., Schneikert, J., & Behrens, J. (2007) · Journal of Cell Science · doi:10.1242/jcs.011320 · Cited by 85
Cited by
WNT signaling in bone homeostasis and disease: From human mutations to treatments
Baron, R., & Kneissel, M. (2013) · Nature Medicine · doi:10.1038/nm.3074 · Cited by 2,093
TCF/LEFs and Wnt Signaling in the Nucleus
Cadigan, K. M., & Waterman, M. L. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a007906 · Cited by 760
Self-citationArmadillo-repeat protein functions: questions for little creatures
Tewari, R., Bailes, E., Bunting, K. A., & Coates, J. C. (2010) · Trends in Cell Biology · doi:10.1016/j.tcb.2010.05.003 · Cited by 259
MITF drives endolysosomal biogenesis and potentiates Wnt signaling in melanoma cells
Ploper, D., Taelman, V. F., Robert, L., Perez, B. S., Titz, B., Chen, H.-W., Graeber, T. G., von Euw, E., Ribas, A., & De Robertis, E. M. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1424576112 · Cited by 228
NLK-mediated phosphorylation of HDAC1 negatively regulates Wnt signaling
Masoumi, K. C., Daams, R., Sime, W., Siino, V., Ke, H., Levander, F., & Massoumi, R. (2017) · Molecular Biology of the Cell · doi:10.1091/mbc.e16-07-0547 · Cited by 35
Metadata
- Authors
- Cadigan, K. M., & Peifer, M.
- Venue
- Cold Spring Harbor Perspectives in Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2009-08-01
- Volume
- 1
- Issue
- 2
- Pages
- a002881-a002881
- ISSN
- 1943-0264 (ISSN-L)
- OpenAlex
- W4301326813
- Cited by
- 302
- References
- 10
- Type
- posted content
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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