The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Synaptic Vesicle Exocytosis
Open accessAbstract
Presynaptic nerve terminals release neurotransmitters by synaptic vesicle exocytosis. Membrane fusion mediating synaptic exocytosis and other intracellular membrane traffic is affected by a universal machinery that includes SNARE (for "soluble NSF-attachment protein receptor") and SM (for "Sec1/Munc18-like") proteins. During fusion, vesicular and target SNARE proteins assemble into an α-helical trans-SNARE complex that forces the two membranes tightly together, and SM proteins likely wrap around assembling trans-SNARE complexes to catalyze membrane fusion. After fusion, SNARE complexes are dissociated by the ATPase NSF (for "N-ethylmaleimide sensitive factor"). Fusion-competent conformations of SNARE proteins are maintained by chaperone complexes composed of CSPα, Hsc70, and SGT, and by nonenzymatically acting synuclein chaperones; dysfunction of these chaperones results in neurodegeneration. The synaptic membrane-fusion machinery is controlled by synaptotagmin, and additionally regulated by a presynaptic protein matrix (the "active zone") that includes Munc13 and RIM proteins as central components.
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Cites
Südhof, T. C. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.26.041002.131412 · Cited by 2,547
Self-citationCrystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 Å resolution
Sutton, R. B., Fasshauer, D., Jahn, R., & Brunger, A. T. (1998) · Nature · doi:10.1038/26412 · Cited by 2,417 · cited 2×
“3C,D) (Poirier et al. 1998; Sutton et al. 1998), with one SNARE motif each from synaptobrevin and syntaxin-1, and two SNARE motifs from SNAP-25.”
BackgroundMolecular anatomy of a trafficking organelle
Takamori, S., Holt, M., Stenius, K., Lemke, E. A., Grønborg, M., Riedel, D., Urlaub, H., Schenck, S., Brügger, B., Ringler, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.10.030 · Cited by 2,373
Membrane Fusion: Grappling with SNARE and SM Proteins
Südhof, T. C., & Rothman, J. E. (2009) · Science · doi:10.1126/science.1161748 · Cited by 2,027
Munc13-1 is essential for fusion competence of glutamatergic synaptic vesicles
Augustin, I., Rosenmund, C., Südhof, T. C., & Brose, N. (1999) · Nature · doi:10.1038/22768 · Cited by 787
Self-citationRIBEYE, a Component of Synaptic Ribbons
Schmitz, F., Königstorfer, A., & Südhof, T. C. (2000) · Neuron · doi:10.1016/s0896-6273(00)00159-8 · Cited by 581
Self-citationRIM1α forms a protein scaffold for regulating neurotransmitter release at the active zone
Schoch, S., Castillo, P. E., Jo, T., Mukherjee, K., Geppert, M., Wang, Y., Schmitz, F., Malenka, R. C., & Südhof, T. C. (2002) · Nature · doi:10.1038/415321a · Cited by 579
Self-citationMunc13 mediates the transition from the closed syntaxin–Munc18 complex to the SNARE complex
Ma, C., Li, W., Xu, Y., & Rizo, J. (2011) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2047 · Cited by 363
Self-citationPiccolo, a presynaptic zinc finger protein structurally related to bassoon
Fenster, S. D., Chung, W. J., Zhai, R., Cases-Langhoff, C., Voss, B., Garner, A. M., Kaempf, U., Kindler, S., Gundelfinger, E. D., & Garner, C. C. (2000) · Neuron · doi:10.1016/s0896-6273(00)80883-1 · Cited by 295
Conformational switch of syntaxin-1 controls synaptic vesicle fusion
Gerber, S. H., Rah, J.-C., Min, S.-W., Liu, X., de Wit, H., Dulubova, I., Meyer, A. C., Rizo, J., Arancillo, M., Hammer, R. E., et al. (2008) · Science · doi:10.1126/science.1163174 · Cited by 294
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Cited by
Pathology of Neurodegenerative Diseases
Dugger, B. N., & Dickson, D. W. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a028035 · Cited by 1,665
Coming together to define membrane contact sites
Scorrano, L., De Matteis, M. A., Emr, S., Giordano, F., Hajnóczky, G., Kornmann, B., Lackner, L. L., Levine, T. P., Pellegrini, L., Reinisch, K., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09253-3 · Cited by 730
The Role of Mitochondrially Derived ATP in Synaptic Vesicle Recycling
Pathak, D., Shields, L. Y., Mendelsohn, B. A., Haddad, D., Lin, W., Gerencser, A. A., Kim, H., Brand, M. D., Edwards, R. H., & Nakamura, K. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.656405 · Cited by 311
Exosomes Derived from Mesenchymal Stromal Cells Promote Axonal Growth of Cortical Neurons
Zhang, Y., Chopp, M., Liu, X. S., Katakowski, M., Wang, X., Tian, X., Wu, D., & Zhang, Z. G. (2017) · Molecular Neurobiology · doi:10.1007/s12035-016-9851-0 · Cited by 300
Synaptic Vesicle Pools and Dynamics
Alabi, A. A., & Tsien, R. W. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a013680 · Cited by 284
Metadata
- Authors
- Sudhof, T. C., & Rizo, J.
- Venue
- Cold Spring Harbor Perspectives in Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2011-10-25
- Volume
- 3
- Issue
- 12
- Pages
- a005637-a005637
- ISSN
- 1943-0264 (ISSN-L)
- OpenAlex
- W2172212230
- Cited by
- 510
- References
- 17
- Type
- posted content
- Language
- en
- Open access
- bronze
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