Proteolytic Degradation of Amyloid -Protein

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Items 101–200 of 369

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2. Unraveling Alzheimer’s: Making Sense of the Relationship between Diabetes and Alzheimer’s Disease
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3. Alzheimer’s Disease: A Molecular View of β-Amyloid Induced Morbific Events
   Rajmohamed Mohamed Asik, Natarajan Suganthy, Mohamed Asik Aarifa, Arvind Kumar, Krisztián Szigeti, Domokos Máthé, Balázs Zoltán Gulyás, Govindaraju Archunan, Parasuraman Padmanabhan · 2021 · Biomedicines
4. A pectin from fruits of Lycium barbarum L. decreases β-amyloid peptide production through modulating APP processing
   Lishuang Zhou, Wenfeng Liao, Hui Zeng, Yanli Yao, Xia Chen, Kan Ding · 2018 · Carbohydrate Polymers
5. Alzheimer's therapy targeting the β-secretase enzyme BACE1: Benefits and potential limitations from the perspective of animal model studies.
   M. Ohno · 2016 · Brain Research Bulletin
6. Apolipoprotein E, amyloid-ß clearance and therapeutic opportunities in Alzheimer's disease
   Adam D. Kline · 2012 · Alzheimer s Research & Therapy
7. Advances in Amyloid-β Clearance in the Brain and Periphery: Implications for Neurodegenerative Diseases
   Rahat Ullah, Eun Jeong Lee · 2023 · Experimental Neurobiology
8. Emerging Roles of Meningeal Lymphatic Vessels in Alzheimer’s Disease
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9. Oxidative inactivation of amyloid beta-degrading proteases by cholesterol-enhanced mitochondrial stress
   Cristina de Dios, Isabel Bartolessis, Vicente Roca Agujetas, Elisabet Barbero‐Camps, Montserrat Marı́, Albert Morales, Anna Colell · 2019 · Redox Biology
10. Protective Effect of Natural Antioxidant, Curcumin Nanoparticles, and Zinc Oxide Nanoparticles against Type 2 Diabetes-Promoted Hippocampal Neurotoxicity in Rats
    Shaymaa A. Abdulmalek, Mayada Nasef, Doaa Awad, Mahmoud Balbaa · 2021 · Pharmaceutics
11. Reduction of amyloid-beta levels in mouse eye tissues by intra-vitreally delivered neprilysin
    Rajni Parthasarathy, K. Martin Chow, Zahra Derafshi, Michael P. Fautsch, John R. Hetling, David W. Rodgers, Louis B. Hersh, David R. Pepperberg · 2015 · Experimental Eye Research
12. Amyloidosis in Retinal Neurodegenerative Diseases
    Ambra Masuzzo, Virginie Dinet, Chelsea Cavanagh, Frédéric Mascarelli, Slavica M Krantic · 2016 · Frontiers in Neurology
13. The effect of angiotensin receptor neprilysin inhibitor, sacubitril/valsartan, on central nervous system amyloid-β concentrations and clearance in the cynomolgus monkey
    Heidi A. Schoenfeld, Tim West, Philip B. Verghese, Mary S. Holubasch, Neeta Shenoy, David Kagan, Chiara Buono, Wei Zhou, Marc F. DeCristofaro, Julie Douville et al. · 2017 · Toxicology and Applied Pharmacology
14. Aggregation kinetics of the Aβ1–40 peptide monitored by NMR
    Giovanni Bellomo, Sara Bologna, Leonardo Gonnelli, Enrico Ravera, Marco Fragai, Moreno Lelli, Claudio Luchinat · 2018 · Chemical Communications
15. Peptidomimetic-Based Vesicles Inhibit Amyloid-β Fibrillation and Attenuate Cytotoxicity
    Debabrata Maity, Madeline Howarth, Maria Chalokh Vogel, Mazin M. Magzoub, Andrew D. Hamilton · 2021 · Journal of the American Chemical Society
16. Misframed ubiquitin and impaired protein quality control: an early event in Alzheimer’s disease
    Romina J. G. Gentier, Fred W. van Leeuwen · 2015 · Frontiers in Molecular Neuroscience
17. Amyloid Fibrils from Hemoglobin
    Nadishka Jayawardena, Manmeet Kaur, Smitha Nair, Jenny Malmström, David C. Goldstone, Leonardo Negron, Juliet A. Gerrard, Laura J. Domigan · 2017 · Biomolecules
18. Heparan sulfate proteoglycan in Alzheimer’s disease: aberrant expression and functions in molecular pathways related to amyloid-β metabolism
    Ilayda Ozsan McMillan, Jin‐Ping Li, Lianchun Wang · 2023 · American Journal of Physiology-Cell Physiology
19. Major amyloid-β degrading enzymes endothelin-converting enzyme-2 and neprilysin are expressed by distinct populations of GABAergic interneurons in hippocampus and neocortex
    Javier Pacheco-Quinto, C. Eckman, E. Eckman · 2016 · Neurobiology of Aging
20. In vivo Differential Brain Clearance and Catabolism of Monomeric and Oligomeric Alzheimer's Aβ protein
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21. Impacts of oxidants and antioxidants on the emergence and progression of Alzheimer's disease
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22. The synergistic effect between KLVFF and self-assembly chaperones on both disaggregation of beta-amyloid fibrils and reducing consequent toxicity
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23. Meta-analysis of expression and function of neprilysin in Alzheimer’s disease
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24. From Soluble A β to Progressive A β Aggregation: Could Prion‐Like Templated Misfolding Play a Role?
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25. A Lipoprotein Receptor Cluster IV Mutant Preferentially Binds Amyloid-β and Regulates Its Clearance from the Mouse Brain
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26. Vascular mTOR-dependent mechanisms linking the control of aging to Alzheimer's disease
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27. HMGB1 signaling pathway in diabetes-related dementia: Blood-brain barrier breakdown, brain insulin resistance, and Aβ accumulation
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28. Common Pesticide, Dichlorodiphenyltrichloroethane (DDT), Increases Amyloid-β Levels by Impairing the Function of ABCA1 and IDE: Implication for Alzheimer’s Disease
    Li, Gongbo, Kim, Chaeyoung, Kim, Jaekwang, Yoon, Hyejin, Zhou, Huadong, Kim, Jungsu · 2015 · Journal of Alzheimer's Disease
29. IKK2/NF-κB Activation in Astrocytes Reduces amyloid β Deposition: A Process Associated with Specific Microglia Polarization
    Shu Yang, A. Magnutzki, Najwa Ouali Alami, M. Lattke, T. Hein, Judith S. Scheller, Carsten Kröger, F. Oswald, D. Yilmazer-Hanke, T. Wirth et al. · 2021 · Cells
30. Multi-functional role of apolipoprotein E in neurodegenerative diseases
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31. Mechanisms that lessen benefits of β-secretase reduction in a mouse model of Alzheimer's disease
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32. Amyloid-β 1–24 C-terminal truncated fragment promotes amyloid-β 1–42 aggregate formation in the healthy brain
    Sonia Mazzitelli, Fabia Filipello, Marco Rasile, Eliana Lauranzano, Chiara Starvaggi Cucuzza, Matteo Tamborini, Davide Pozzi, Isabella Barajon, Toni Giorgino A, Antonino Natalello et al. · 2016 · Acta Neuropathologica Communications
33. Modelling Sporadic Alzheimer’s Disease Using Induced Pluripotent Stem Cells
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34. Experimental alcoholism primes structural and functional impairment of the glymphatic pathway
    Qiang Liu, Lingli Yan, Miaodan Huang, Haitao Zeng, Senthil Kumaran Satyanarayanan, Zhe Shi, Dingbang Chen, Jiahong Lu, Zhong Pei, Xiaoli Yao et al. · 2019 · Brain Behavior and Immunity
35. A combination Alzheimer’s therapy targeting BACE1 and neprilysin in 5XFAD transgenic mice
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36. Interplay between Copper, Neprilysin, and N-Truncation of β-Amyloid
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37. AC-186, a Selective Nonsteroidal Estrogen Receptor β Agonist, Shows Gender Specific Neuroprotection in a Parkinson’s Disease Rat Model
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38. Piceatannol, a natural analogue of resveratrol, effectively reduces beta-amyloid levels via activation of alpha-secretase and matrix metalloproteinase-9
    Boyoung Choi, Suyeon Kim, Bong-Geum Jang, Min-Ju Kim · 2016 · Journal of Functional Foods
39. Aberrant proteolytic processing and therapeutic strategies in Alzheimer disease
    Taisuke Tomita · 2017 · Advances in Biological Regulation
40. Dysregulated Metabolism of the Amyloid‐β Protein and Therapeutic Approaches in Alzheimer Disease
    Kazunori Kikuchi, Kiwami Kidana, Takuya Tatebe, Taisuke Tomita · 2017 · Journal of Cellular Biochemistry
41. Altered Processing of β-Amyloid in SH-SY5Y Cells Induced by Model Senescent Microglia
    Dafina M. Angelova, David R. Brown · 2018 · ACS Chemical Neuroscience
42. The Role of Extracellular Matrix Components in the Spreading of Pathological Protein Aggregates
    Edoardo Moretto, Skye Stuart, Sunaina Surana, Jose Norberto S. Vargas, Giampietro Schiavo · 2022 · Frontiers in Cellular Neuroscience
43. Molecular basis of selective amyloid‐β degrading enzymes in Alzheimer's disease
    Joanna Żukowska, Stephen J. Moss, Vasanta Subramanian, K. Ravi Acharya · 2023 · FEBS Journal
44. PSD-93 Attenuates Amyloid-β-Mediated Cognitive Dysfunction by Promoting the Catabolism of Amyloid-β
    Linjie Yu, Yi Liu, Hui Yang, Xiaolei Zhu, Xiang Cao, Jun Gao, Hui Zhao, Yun Xu · 2017 · Journal of Alzheimer s Disease
45. Insights into the Pathophysiology of Alzheimer’s Disease and Potential Therapeutic Targets: A Current Perspective
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46. Beta-amyloidolysis and glutathione in Alzheimer’s disease
    J. Lasierra-Cirujeda, P. Coronel, M. Aza, M. Gimeno · 2013 · Journal of Blood Medicine
47. Revolutionizing Alzheimer's treatment: Harnessing human serum albumin for targeted drug delivery and therapy advancements
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48. REMOVED: Nanowired delivery of cerebrolysin with neprilysin and p-Tau antibodies induces superior neuroprotection in Alzheimer's disease
    Hari Shanker Sharma, Dafin Fior Muresanu, Ala Nozari, José Vicente Lafuente, Z. Ryan Tian, Asya Ozkızılcık, Igor Manzhulo, Herbert Mössler, Aruna Sharma · 2019 · Progress in brain research
49. Plasmonic nanoparticle amyloid corona for screening Aβ oligomeric aggregate-degrading drugs
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50. The clearance of misfolded proteins in neurodegenerative diseases by zinc metalloproteases: An inorganic perspective
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51. Influential role of 7-Ketocholesterol in the progression of Alzheimer’s disease
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52. Activation of Microbiota Sensing – Free Fatty Acid Receptor 2 Signaling Ameliorates Amyloid-β Induced Neurotoxicity by Modulating Proteolysis-Senescence Axis
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53. Review of Advanced Drug Trials Focusing on the Reduction of Brain Beta-Amyloid to Prevent and Treat Dementia
    Boris Decourt, Keith Noorda, Kevin J. Noorda, Jiong Shi, Marwan Noel Sabbagh · 2022 · Journal of Experimental Pharmacology
54. Metabolite Clearance During Wakefulness and Sleep
    Stephen B. Hladky, Margery A. Barrand · 2017 · Handbook of experimental pharmacology
55. Antiretroviral Drugs Promote Amyloidogenesis by De-Acidifying Endolysosomes
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56. Somatostatin receptor subtype-4 agonist NNC 26-9100 mitigates the effect of soluble Aβ42 oligomers via a metalloproteinase-dependent mechanism
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57. Impaired synaptic function is linked to cognition in Parkinson's disease
    Per Selnes, Ane Løvli Stav, Krisztina Kunszt Johansen, Atle Bjørnerud, Christopher S. Coello, Eirik Auning, Lisa Flem Kalheim, Ina S. Almdahl, Erik Hessen, Henrik Zetterberg et al. · 2017 · Annals of Clinical and Translational Neurology
58. The ethanol extract of Zizyphus jujuba var. spinosa seeds ameliorates the memory deficits in Alzheimer's disease model mice
    Hye Jin Park, In Ho Jung, Huiyoung Kwon, Jimin Yu, Eunbi Jo, Haneul Kim, Se Jin Park, Young Choon Lee, Dong Hyun Kim, Jong Hoon Ryu · 2018 · Journal of Ethnopharmacology
59. In Vitro Investigation of Amyloid-β Hepatobiliary Disposition in Sandwich-Cultured Primary Rat Hepatocytes
    Loqman A. Mohamed, Amal Kaddoumi · 2013 · Drug Metabolism and Disposition
60. Somatostatin Receptor Subtype-4 Regulates mRNA Expression of Amyloid-Beta Degrading Enzymes and Microglia Mediators of Phagocytosis in Brains of 3xTg-AD Mice
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61. The antimicrobial protein, CAP37, is upregulated in pyramidal neurons during Alzheimer’s disease
    Amanda J. Brock, Anne Kasus‐Jacobi, Megan R. Lerner, Sreemathi Logan, Adekunle M. Adesina, Heloise Anne Pereira · 2015 · Histochemistry and Cell Biology
62. Amylin Enhances Amyloid-β Peptide Brain to Blood Efflux Across the Blood-Brain Barrier
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63. A Fundamental Role for Oxidants and Intracellular Calcium Signals in Alzheimer’s Pathogenesis—And How a Comprehensive Antioxidant Strategy May Aid Prevention of This Disorder
    Mark Frederick McCarty, James J. DiNicolantonio, Aaron Lerner · 2021 · International Journal of Molecular Sciences
64. Telmisartan Alleviates Alzheimer’s Disease-Related Neuropathologies and Cognitive Impairments
    Xinxin Fu, Bin Wei, Haiming Cao, Rui Duan, Yang Deng, Hui-Wen Lian, Yingdong Zhang, Teng Jiang · 2023 · Journal of Alzheimer s Disease
65. Alzheimer’s Disease: Models and Molecular Mechanisms Informing Disease and Treatments
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66. A plasma proteolysis pathway comprising blood coagulation proteases
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67. Cerebrospinal Fluid Biomarkers in Alzheimer’s Disease—From Brain Starch to Bench and Bedside
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68. Transferrin-Conjugated Melittin-Loaded L-Arginine-Coated Iron Oxide Nanoparticles for Mitigating Beta-Amyloid Pathology of the 5XFAD Mouse Brain
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69. Distinct spatiotemporal accumulation of N-truncated and full-length amyloid-β42 in Alzheimer’s disease
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70. Regulation of amyloid-β levels by matrix metalloproteinase-2/9 (MMP2/9) in the media of lung cancer cells
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71. Medium-Chain Length Fatty Acids Enhance Aβ Degradation by Affecting Insulin-Degrading Enzyme
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72. N-terminally truncated Aβ4-x proteoforms and their relevance for Alzheimer’s pathophysiology
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73. Aβ-degrading proteases:therapeutic potential in Alzheimer disease
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74. The Amyloid‐β Peptide in Amyloid Formation Processes: Interactions with Blood Proteins and Naturally Occurring Metal Ions
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75. Calcium (Ca2+) hemostasis, mitochondria, autophagy, and mitophagy contribute to Alzheimer's disease as early moderators
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76. Regulatory role of the endocannabinoid system on glial cells toward cognitive function in Alzheimer’s disease: A systematic review and meta-analysis of animal studies
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77. Prominent tauopathy and intracellular β-amyloid accumulation triggered by genetic deletion of cathepsin D: implications for Alzheimer disease pathogenesis
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78. GPR120 Signaling Controls Amyloid-β Degrading Activity of Matrix Metalloproteinases
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79. Alzheimer’s Amyloid β Peptide Induces Angiogenesis in an Alzheimer’s Disease Model Mouse through Placental Growth Factor and Angiopoietin 2 Expressions
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80. NET amyloidogenic backbone in human activated neutrophils
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81. Self-Assembly Molecular Chaperone to Concurrently Inhibit the Production and Aggregation of Amyloid β Peptide Associated with Alzheimer’s Disease
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82. Pathology of Amyloid-β (Aβ) Peptide Peripheral Clearance in Alzheimer’s Disease
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83. A lysosomal surveillance response to stress extends healthspan
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84. Patient-Derived Fibroblasts With Presenilin-1 Mutations, That Model Aspects of Alzheimer’s Disease Pathology, Constitute a Potential Object for Early Diagnosis
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85. TANGO-Inspired Design of Anti-Amyloid Cyclic Peptides
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86. Dynamic alteration of neprilysin and endothelin-converting enzyme in age-dependent APPswe/PS1dE9 mouse model of Alzheimer's disease.
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88. The β-Secretase Enzyme BACE1: A Biochemical Enigma for Alzheimer’s Disease
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89. Advances in sample preparation and HPLC–MS/MS methods for determining amyloid-β peptide in biological samples: a review
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90. TRPM7 kinase activity induces amyloid-β degradation to reverse synaptic and cognitive deficits in mouse models of Alzheimer’s disease
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91. Regulation of distinct pools of amyloid β-protein by multiple cellular proteases
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92. Acute and Chronic Sustained Hypoxia Do Not Substantially Regulate Amyloid-β Peptide Generation In Vivo
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93. Differences in the Relative Abundance of ProBDNF and Mature BDNF in A549 and H1299 Human Lung Cancer Cell Media
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94. Refining the amyloid β peptide and oligomer fingerprint ambiguities in Alzheimer’s disease: Mass spectrometric molecular characterization in brain, cerebrospinal fluid, blood, and plasma
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95. The Relationships Among Metal Homeostasis, Mitochondria, and Locus Coeruleus in Psychiatric and Neurodegenerative Disorders: Potential Pathogenetic Mechanism and Therapeutic Implications
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96. Alzheimer's disease treatment: The share of herbal medicines.
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97. The Role of Neprilysin and Insulin-Degrading Enzyme in the Etiology of Sporadic Alzheimer's Disease
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98. Identification of peptide products from enzymatic degradation of amyloid beta
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99. Protein accumulation in the endoplasmic reticulum as a non-equilibrium phase transition
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100. Overexpression of the Insulin-Like Growth Factor II Receptor Increases β-Amyloid Production and Affects Cell Viability
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