The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Death Receptor-Ligand Systems in Cancer, Cell Death, and Inflammation
Open accessAbstract
The discovery of tumor necrosis factor (TNF) marked the beginning of one of the most fascinating journeys in modern biomedical research. For the moment, this journey has culminated in the development of drugs that inhibit TNF. TNF blockers have revolutionized the treatment of many chronic inflammatory diseases. Yet, the journey seems far from over. TNF is the founding member of a family of cytokines with crucial functions in cell death, inflammation, and cancer. Some of these factors, most prominently TNF, CD95L, and TRAIL, can induce cell death. The receptors that mediate this signal are therefore referred to as death receptors, even though they also activate other signals. Here I will take you on a journey into the discovery and study of death receptor-ligand systems and how this inspired new concepts in cancer therapy and our current understanding of the interplay between cell death and inflammation.
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Citations
Cites
1 retracted
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Cited by
Targeting apoptosis in cancer therapy
Carneiro, B. A., & El-Deiry, W. S. (2020) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-0341-y · Cited by 2,542
Essential versus accessory aspects of cell death: recommendations of the NCCD 2015
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Exploring the TRAILs less travelled: TRAIL in cancer biology and therapy
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Self-citation
Metadata
- Authors
- Walczak, H.
- Venue
- Cold Spring Harbor Perspectives in Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2013-05-01
- Volume
- 5
- Issue
- 5
- Pages
- a008698-a008698
- ISSN
- 1943-0264 (ISSN-L)
- OpenAlex
- W2158079918
- Cited by
- 242
- References
- 24
- Type
- posted content
- Language
- en
- Open access
- bronze
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