The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Microbial Sensing by Toll-Like Receptors and Intracellular Nucleic Acid Sensors
Open accessAbstract
Recognition of an invading pathogen is critical to elicit protective responses. Certain microbial structures and molecules, which are crucial for their survival and virulence, are recognized by different families of evolutionarily conserved pattern recognition receptors (PRRs). This recognition initiates a signaling cascade that leads to the transcription of inflammatory cytokines and chemokines to eliminate pathogens and attract immune cells, thereby perpetuating further adaptive immune responses. Considerable research on the molecular mechanisms underlying host-pathogen interactions has resulted in the discovery of multifarious PRRs. In this review, we discuss the recent developments in microbial recognition by Toll-like receptors (TLRs) and intracellular nucleic acid sensors and the signaling pathways initiated by them.
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Cites
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Metadata
- Authors
- Pandey, S., Kawai, T., & Akira, S.
- Venue
- Cold Spring Harbor Perspectives in Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2014-10-09
- Volume
- 7
- Issue
- 1
- Pages
- a016246
- ISSN
- 1943-0264 (ISSN-L)
- OpenAlex
- W2107387055
- Cited by
- 365
- References
- 24
- Type
- posted content
- Language
- en
- Open access
- bronze
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