The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Glia Disease and Repair—Remyelination
Open accessAbstract
The inability of the mammalian central nervous system (CNS) to undergo spontaneous regeneration has long been regarded as a central tenet of neurobiology. However, although this is largely true of the neuronal elements of the adult mammalian CNS, save for discrete populations of granular neurons, the same is not true of its glial elements. In particular, the loss of oligodendrocytes, which results in demyelination, triggers a spontaneous and often highly efficient regenerative response, remyelination, in which new oligodendrocytes are generated and myelin sheaths are restored to denuded axons. Yet, remyelination in humans is not without limitation, and a variety of demyelinating conditions are associated with sustained and disabling myelin loss. In this review, we will review the biology of remyelination, including the cells and signals involved; describe when remyelination occurs and when and why it fails and the consequences of its failure; and discuss approaches for therapeutically enhancing remyelination in demyelinating diseases of both children and adults, both by stimulating endogenous oligodendrocyte progenitor cells and by transplanting these cells into demyelinated brain.
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Cites
Rejuvenation of aged progenitor cells by exposure to a young systemic environment
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M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination
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Self-citationOligodendroglia metabolically support axons and contribute to neurodegeneration
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Remyelination in the CNS: from biology to therapy
Franklin, R. J. M., & ffrench-Constant, C. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2480 · Cited by 1,544
Self-citationDisruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination
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TNFα promotes proliferation of oligodendrocyte progenitors and remyelination
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Premyelinating Oligodendrocytes in Chronic Lesions of Multiple Sclerosis
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Axonal Swellings and Degeneration in Mice Lacking the Major Proteolipid of Myelin
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Myelin Impairs CNS Remyelination by Inhibiting Oligodendrocyte Precursor Cell Differentiation
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Self-citation
Cited by
Reich, D. S., Lucchinetti, C. F., & Calabresi, P. A. (2018) · New England Journal of Medicine · doi:10.1056/nejmra1401483 · Cited by 2,491
Oligodendrocyte Development and Plasticity
Bergles, D. E., & Richardson, W. D. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020453 · Cited by 585
Oligodendrocyte, Astrocyte, and Microglia Crosstalk in Myelin Development, Damage, and Repair
Domingues, H. S., Portugal, C. C., Socodato, R., & Relvas, J. B. (2016) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2016.00071 · Cited by 432
Enhancing myelin renewal reverses cognitive dysfunction in a murine model of Alzheimer’s disease
Chen, J.-F., Liu, K., Hu, B., Li, R.-R., Xin, W., Chen, H., Wang, F., Chen, L., Li, R.-X., Ren, S.-Y., et al. (2021) · Neuron · doi:10.1016/j.neuron.2021.05.012 · Cited by 346
Glia in mammalian development and disease
Zuchero, J. B., & Barres, B. A. (2015) · Development · doi:10.1242/dev.129304 · Cited by 304
Metadata
- Authors
- Franklin, R. J. M., & Goldman, S. A.
- Venue
- Cold Spring Harbor Perspectives in Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2015-05-18
- Volume
- 7
- Issue
- 7
- Pages
- a020594
- ISSN
- 1943-0264 (ISSN-L)
- OpenAlex
- W1861300743
- Cited by
- 208
- References
- 36
- Type
- posted content
- Language
- en
- Open access
- bronze
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