Cited by 774Multiple Sclerosis Research StudiesNeurogenesis and neuroplasticity mechanismsNeuroinflammation and Neurodegeneration Mechanisms

Myelin Impairs CNS Remyelination by Inhibiting Oligodendrocyte Precursor Cell Differentiation

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Kotter, Mark R., Li, Wen-Wu, Zhao, Chao, Franklin, Robin J. M.·2006·The Journal of Neuroscience

Abstract

Demyelination in the adult CNS can be followed by extensive repair. However, in multiple sclerosis, the differentiation of oligodendrocyte lineage cells present in demyelinated lesions is often inhibited by unknown factors. In this study, we test whether myelin debris, a feature of demyelinated lesions and an in vitro inhibitor of oligodendrocyte precursor differentiation, affects remyelination efficiency. Focal demyelinating lesions were created in the adult rat brainstem, and the naturally generated myelin debris was augmented by the addition of purified myelin. After quantification of myelin basic protein mRNA expression from lesion material obtained by laser capture microdissection and supported by histological data, we found a significant impairment of remyelination, attributable to an arrest of the differentiation and not the recruitment of oligodendrocyte precursor cells. These data identify myelin as an inhibitor of remyelination as well as its well documented inhibition of axon regeneration.

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Crossref · 10.1523/jneurosci.2615-05.2006

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Authors
Kotter, M. R., Li, W.-W., Zhao, C., & Franklin, R. J. M.
Affiliations
University of Cambridge (GB)
Venue
The Journal of Neuroscience
Published
2006-01-04
Volume
26
Issue
1
Pages
328-332
ISSN
  • 0270-6474 (ISSN-L)
  • 1529-2401
OpenAlex
W2094044389
Cited by
768
References
30
Citations by year
2026: 24 · 2025: 39 · 2024: 63 · 2023: 56 · 2022: 48 · 2021: 56 · 2020: 46 · 2019: 58 · 2018: 34 · 2017: 41 · 2016: 39 · 2015: 40 · 2014: 34 · 2013: 43 · 2012: 25
FWCI
15.22
Type
journal article
Language
en
Open access
Locations
  • Journal of Neuroscience (publishedVersion, public-domain)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Raymond and Beverly Sackler Foundation
  • Multiple Sclerosis Society
  • Austrian Science Fund
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
remyelination, myelin debris, oligodendrocyte precursor cells, oligodendrocyte differentiation, demyelination, multiple sclerosis, myelin basic protein, demyelinating lesions, axon regeneration, central nervous system repair
MeSH terms
Animals, Cell Differentiation, Central Nervous System, Female, Growth Inhibitors, Myelin Sheath, Nerve Fibers, Myelinated, Neural Inhibition, Oligodendroglia, Stem Cells, Rats, Sprague-Dawley, Rats

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