Glia in mammalian development and disease
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Glia account for more than half of the cells in the mammalian nervous system, and the past few decades have witnessed a flood of studies that detail novel functions for glia in nervous system development, plasticity and disease. Here, and in the accompanying poster, we review the origins of glia and discuss their diverse roles during development, in the adult nervous system and in the context of disease.
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The results are consistent with literature indicating that different types of glia may contribute to Alzheimer's disease via different regulatory mechanisms.
“These results are consistent with a newly emerging literature which indicates that different types of glia may contribute to the disease via different regulatory mechanisms55–57.”
From Neuronal and glial 3D chromatin architecture informs the cellular etiology of brain disorders (2021) · cites this paper as [57]
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- Schafer D. P. and Stevens B. (2015). Microglia function in central nervous system development and plasticity. Cold Spring Harb. Perspect. Biol. 7, a020545 10.1101/cshperspect.a020545 [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI · Paper page
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- Authors
- Zuchero, J. B., & Barres, B. A.
- Affiliations
- Stanford Medicine (US)
- Corresponding author
- Zuchero, J. Bradley
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2015-11-15
- Volume
- 142
- Issue
- 22
- Pages
- 3805-3809
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- PMC
- PMC4712885
- OpenAlex
- W2205666820
- Cited by
- 304
- References
- 51
- Citations by year
- 2026: 11 · 2025: 15 · 2024: 12 · 2023: 22 · 2022: 39 · 2021: 50 · 2020: 39 · 2019: 37 · 2018: 30 · 2017: 32 · 2016: 17
- FWCI
- 3.29
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Development (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Multiple Sclerosis Society
- National Institutes of Health
- National Eye Institute
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- glia, brain development, glial plasticity, adult nervous system, mammalian nervous system
- MeSH terms
- Animals, Astrocytes, Mammals, Myelin Sheath, Nerve Regeneration, Nervous System, Neuroglia, Neuronal Plasticity, Oligodendroglia, Schwann Cells, Microglia
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