The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Expansion and contraction of ribosomal DNA repeats in Saccharomyces cerevisiae: requirement of replication fork blocking (Fob1) protein and the role of RNA polymerase I
Open accessAbstract
Saccharomyces cerevisiae carries ∼150 copies of rDNA in tandem repeats. It was found that the absence of an essential subunit of RNA polymerase I (Pol I) in rpa135 deletion mutants triggers a gradual decrease in rDNA repeat number to about one-half the normal level. Reintroduction of the missing RPA135 gene induced a gradual increase in repeat number back to the normal level. Gene FOB1 was shown to be essential for both the decrease and increase of rDNA repeats. FOB1 was shown previously to be required for replication fork blocking (RFB) activity at RFB site in rDNA and for recombination hot-spot (HOT1) activity. Thus, DNA replication fork blockage appears to stimulate recombination and play an essential role in rDNA expansion/contraction and sequence homogenization, and possibly, in the instability of repeated sequences in general. RNA Pol I, on the other hand, appears to control repeat numbers, perhaps by stabilizing rDNA with the normal repeat numbers as a stable nucleolar structure.
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Citations
Cites
RECOMBINATIONAL CONTROLS OF rDNA REDUNDANCY IN DROSOPHILA
Hawley, R. S., & Marcus, C. H. (1989) · Annual Review of Genetics · doi:10.1146/annurev.ge.23.120189.000511 · Cited by 85
Cited by
Kaeberlein, M., McVey, M., & Guarente, L. (1999) · Genes & Development · doi:10.1101/gad.13.19.2570 · Cited by 2,253
Replication fork stalling at natural impediments
Mirkin, E. V., & Mirkin, S. M. (2007) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00030-06 · Cited by 482
The correlation between rDNA copy number and genome size in eukaryotes
Prokopowich, C. D., Gregory, T. R., & Crease, T. J. (2003) · Genome · doi:10.1139/g02-103 · Cited by 441
Gene Copy-Number Alterations: A Cost-Benefit Analysis
Tang, Y.-C., & Amon, A. (2013) · Cell · doi:10.1016/j.cell.2012.11.043 · Cited by 348
Lofgren, L. A., Uehling, J. K., Branco, S., Bruns, T. D., Martin, F., & Kennedy, P. G. (2019) · Molecular Ecology · doi:10.1111/mec.14995 · Cited by 267
Metadata
- Authors
- Kobayashi, T., Heck, D. J., Nomura, M., & Horiuchi, T.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1998-12-15
- Volume
- 12
- Issue
- 24
- Pages
- 3821-3830
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2127229045
- Cited by
- 388
- References
- 1
- Type
- posted content
- Language
- en
- Open access
- diamond
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- CoChat. (2026). Citation check: Expansion and contraction of ribosomal DNA repeats in Saccharomyces cerevisiae: requirement of replication fork blocking (Fob1) protein and the role of RNA polymerase I. https://app.cochat.ai/papers/10.1101/gad.12.24.3821
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- Kobayashi, T., Heck, D. J., Nomura, M., & Horiuchi, T. (1998). Expansion and contraction of ribosomal DNA repeats in Saccharomyces cerevisiae: requirement of replication fork blocking (Fob1) protein and the role of RNA polymerase I. Genes & Development. https://doi.org/10.1101/gad.12.24.3821
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
