RECOMBINATIONAL CONTROLS OF rDNA REDUNDANCY IN DROSOPHILA

Hawley, R. Scott; Marcus, Craig H.

doi:10.1146/annurev.ge.23.120189.000511

Cited by 85Chromosomal and Genetic VariationsGenomics and Chromatin DynamicsNuclear Structure and Function

RECOMBINATIONAL CONTROLS OF rDNA REDUNDANCY IN DROSOPHILA

Hawley, R. Scott, Marcus, Craig H.·1989·Annual Review of Genetics

DOI 10.1146/annurev.ge.23.120189.000511

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Abstract

We have made rapid progress in recent years in identifying the genetic causes of many human diseases. However, despite this recent progress, our mechanistic understanding of these diseases is often incomplete. This is a problem because it limits our ...Read More

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Some level of R2 expression may be beneficial for the host because the R2 endonuclease can initiate recombination restoring rDNA clusters in cells with decreased rDNA copy number.
“On the other hand, some level of R2 expression may be beneficial for the host, since it has been suggested that the R2 endonuclease can initiate recombination restoring rDNA clusters in cells with decreased rDNA copy number (45,46).”
From Impaired function of rDNA transcription initiation machinery leads to derepression of ribosomal genes with insertions of R2 retrotransposon (2022) · cites this paper as [45]

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Authors: Hawley, R. S., & Marcus, C. H.
Affiliations: Albert Einstein College of Medicine (US)
ORCID: Hawley, R. Scott
Venue: Annual Review of Genetics
Publisher: Annual Reviews
Published: 1989-12
Volume: 23
Issue: 1
Pages: 87-120
ISSN: 0066-4197 (ISSN-L)
1545-2948
DOI: 10.1146/annurev.ge.23.120189.000511
OpenAlex: W2104702415
Cited by: 85
References: 33
Citations by year: 2026: 1 · 2025: 4 · 2024: 2 · 2023: 4 · 2022: 5 · 2021: 2 · 2018: 1 · 2015: 3 · 2014: 2 · 2013: 2 · 2012: 4
FWCI: 5.52
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Genetics (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
Keywords: ribosomal DNA, recombination, Drosophila, gene conversion, copy number variation
MeSH terms: Animals, DNA, Ribosomal, Drosophila, Mutation, Recombination, Genetic

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RECOMBINATIONAL CONTROLS OF rDNA REDUNDANCY IN DROSOPHILA

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