Cited by 459Telomeres, Telomerase, and SenescenceDNA and Nucleic Acid ChemistryGenetics, Aging, and Longevity in Model Organisms

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POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex

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Ye, Jeffrey Zheng-Sheng, Hockemeyer, Dirk, Krutchinsky, Andrew N., Loayza, Diego, Hooper, Sarah M., Chait, Brian T., de Lange, Titia·2004·Genes & Development

DOI 10.1101/gad.1215404PMC PMC478187

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Abstract

Human telomere length is controlled by a negative feedback loop based on the binding of TRF1 to double-stranded telomeric DNA. The TRF1 complex recruits POT1, a single-stranded telomeric DNA-binding protein necessary for cis-inhibition of telomerase. By mass spectrometry, we have identified a new telomeric protein, which we have named POT1-interacting protein 1 (PIP1). PIP1 bound both POT1 and the TRF1-interacting factor TIN2 and could tether POT1 to the TRF1 complex. Reduction of PIP1 or POT1 levels with shRNAs led to telomere elongation, indicating that PIP1 contributes to telomere length control through recruitment of POT1.

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Authors: Ye, J. Z.-S., Hockemeyer, D., Krutchinsky, A. N., Loayza, D., Hooper, S. M., Chait, B. T., & de Lange, T.
Affiliations: Memorial Sloan Kettering Cancer Center (US)
ORCID: Hockemeyer, Dirk
Krutchinsky, Andrew N.
Loayza, Diego
Chait, Brian T.
Venue: Genes & Development
Publisher: Cold Spring Harbor Laboratory
Published: 2004-07-01
Volume: 18
Issue: 14
Pages: 1649-1654
ISSN: 0890-9369 (ISSN-L)
1549-5477
DOI: 10.1101/gad.1215404
PMC: PMC478187
OpenAlex: W2155983703
Cited by: 459
References: 21
Citations by year: 2026: 4 · 2025: 7 · 2024: 15 · 2023: 18 · 2022: 6 · 2021: 21 · 2020: 12 · 2019: 15 · 2018: 15 · 2017: 16 · 2016: 30 · 2015: 21 · 2014: 34 · 2013: 17 · 2012: 24
Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Genes & Development (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (RR00862)
National Cancer Institute (K08 CA93604, K08CA093604, T32 CA09673-26A1, T32CA009673)
National Center for Research Resources (RR00862, P41RR000862)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords: PIP1, POT1, TIN2, TRF1, telomere length regulation, telomeric proteins, telomerase inhibition, telomere elongation, protein-protein interaction, telomeric DNA
MeSH terms: Shelterin Complex, Carrier Proteins, Cloning, Molecular, Fluorescent Antibody Technique, HeLa Cells, Humans, Mass Spectrometry, Telomere, Two-Hybrid System Techniques, Telomere-Binding Proteins, RNA Interference, Telomeric Repeat Binding Protein 1, Intracellular Signaling Peptides and Proteins

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POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex

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