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Cited by 459Telomeres, Telomerase, and SenescenceDNA and Nucleic Acid ChemistryGenetics, Aging, and Longevity in Model Organisms

The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.

POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex

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Ye, Jeffrey Zheng-Sheng, Hockemeyer, Dirk, Krutchinsky, Andrew N., Loayza, Diego, Hooper, Sarah M., Chait, Brian T., de Lange, Titia·2004·Genes & Development
DOI 10.1101/gad.1215404PMC PMC478187
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Abstract

Human telomere length is controlled by a negative feedback loop based on the binding of TRF1 to double-stranded telomeric DNA. The TRF1 complex recruits POT1, a single-stranded telomeric DNA-binding protein necessary for cis-inhibition of telomerase. By mass spectrometry, we have identified a new telomeric protein, which we have named POT1-interacting protein 1 (PIP1). PIP1 bound both POT1 and the TRF1-interacting factor TIN2 and could tether POT1 to the TRF1 complex. Reduction of PIP1 or POT1 levels with shRNAs led to telomere elongation, indicating that PIP1 contributes to telomere length control through recruitment of POT1.

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  1. 1990, Mol. Cell. Biol., 10, 518
  2. Liu D ., Safari, A., O'Conner, M.S., Chan, D.W., Laegeler, A., Qin, L., and Songyang, Z. 2004. PTOP is a novel POT1 interacting protein that regulates POT1 telomeric localization. Nat. Cell Biol. (in press).

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Metadata

Authors
Ye, J. Z.-S., Hockemeyer, D., Krutchinsky, A. N., Loayza, D., Hooper, S. M., Chait, B. T., & de Lange, T.
Affiliations
Memorial Sloan Kettering Cancer Center (US)
ORCID
Venue
Genes & Development
Publisher
Cold Spring Harbor Laboratory
Published
2004-07-01
Volume
18
Issue
14
Pages
1649-1654
ISSN
  • 0890-9369 (ISSN-L)
  • 1549-5477
DOI
10.1101/gad.1215404
PMC
PMC478187
OpenAlex
W2155983703
Cited by
459
References
21
Citations by year
2026: 4 · 2025: 7 · 2024: 15 · 2023: 18 · 2022: 6 · 2021: 21 · 2020: 12 · 2019: 15 · 2018: 15 · 2017: 16 · 2016: 30 · 2015: 21 · 2014: 34 · 2013: 17 · 2012: 24
Type
posted content
Language
en
Open access
Locations
  • Genes & Development (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (RR00862)
  • National Cancer Institute (K08 CA93604, K08CA093604, T32 CA09673-26A1, T32CA009673)
  • National Center for Research Resources (RR00862, P41RR000862)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords
PIP1, POT1, TIN2, TRF1, telomere length regulation, telomeric proteins, telomerase inhibition, telomere elongation, protein-protein interaction, telomeric DNA
MeSH terms
Shelterin Complex, Carrier Proteins, Cloning, Molecular, Fluorescent Antibody Technique, HeLa Cells, Humans, Mass Spectrometry, Telomere, Two-Hybrid System Techniques, Telomere-Binding Proteins, RNA Interference, Telomeric Repeat Binding Protein 1, Intracellular Signaling Peptides and Proteins

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