The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Wnt signaling in the intestinal epithelium: from endoderm to cancer
Open accessAbstract
The Wnt pathway controls cell fate during embryonic development. It also persists as a key regulator of homeostasis in adult self-renewing tissues. In these tissues, mutational deregulation of the Wnt cascade is closely associated with malignant transformation. The intestinal epithelium represents the best-understood example for the closely linked roles of Wnt signaling in homeostatic self-renewal and malignant transformation. In this review, we outline current understanding of the physiological role of Wnt signaling in intestinal biology. From this perspective, we then describe how mutational subversion of the Wnt cascade leads to colorectal cancer.
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Cites
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Cited by
Identification of stem cells in small intestine and colon by marker gene Lgr5
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Self-citationEpigenetic gene silencing in cancer – a mechanism for early oncogenic pathway addiction?
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Self-citationCytokine/Jak/Stat Signaling Mediates Regeneration and Homeostasis in the Drosophila Midgut
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Metadata
- Authors
- Gregorieff, A., & Clevers, H.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2005-04-15
- Volume
- 19
- Issue
- 8
- Pages
- 877-890
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W1993748871
- Cited by
- 679
- References
- 11
- Type
- posted content
- Language
- en
- Open access
- diamond
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
