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Hypoxia-Induced Angiogenesis: Good and Evil

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The role of oxygen availability in embryonic development and stem cell function

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Epigenetics and the placenta

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Expansion of human SCID-repopulating cells under hypoxic conditions

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Hypoxia-inducible factors in the kidney

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The mitochondrial respiratory chain is essential for haematopoietic stem cell function

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Regulation of Angiogenesis by Hypoxia and Hypoxia‐Inducible Factors

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Vascular endothelial growth factor and vascular adjustments to perturbations in oxygen homeostasis

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Antiangiogenic therapy and tumor progression

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HIF-2α regulates murine hematopoietic development in an erythropoietin-dependent manner

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Hypoxia-Inducible Factors 1α and 2α Regulate Trophoblast Differentiation

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Hypoxia-Inducible Factor 1 Mediates Upregulation of Telomerase (hTERT)

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The HIF family member EPAS1/HIF-2α is required for normal hematopoiesis in mice

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Oxygen in Health and Disease: Regulation of Oxygen Homeostasis-Clinical Implications

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ETV6 fusion genes in hematological malignancies: A review

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The Impact of Hypoxia in Early Pregnancy on Placental Cells

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Hypoxia-inducible factor-dependent histone deacetylase activity determines stem cell fate in the placenta

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Targeted mutation of the murine arylhydrocarbon receptor nuclear translocator 2 ( Arnt2 ) gene reveals partial redundancy with Arnt

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Understanding Hypoxia-Induced Gene Expression in Early Development: In Vitro and In Vivo Analysis of Hypoxia-Inducible Factor 1-Regulated Zebra Fish Insulin-Like Growth Factor Binding Protein 1 Gene Expression

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HIF‐prolyl hydroxylases as therapeutic targets in erythropoiesis and iron metabolism

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Autocrine-paracrine VEGF loops potentiate the maturation of megakaryocytic precursors through Flt1 receptor

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Hematopoietic Progenitor Cell Mobilization Results in Hypoxia with Increased Hypoxia-Inducible Transcription Factor-1α and Vascular Endothelial Growth Factor A in Bone Marrow

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Hypoxia affects mesoderm and enhances hemangioblast specification during early development

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Development of a perfusion fed bioreactor for embryonic stem cell‐derived cardiomyocyte generation: Oxygen‐mediated enhancement of cardiomyocyte output

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Effects of Hypoxia on the Proliferation and Differentiation of NSCs

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Single-cell multi-omics of human clonal hematopoiesis reveals that DNMT3A R882 mutations perturb early progenitor states through selective hypomethylation

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Hypoxia-inducible Factor Regulates αvβ3 Integrin Cell Surface Expression

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Placental cell fates are regulated in vivo by HIF-mediated hypoxia responses

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Hypoxia‐inducible factors in stem cells and cancer

Mazumdar, J., Dondeti, V. R., & Simon, M. C. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00963.x · Cited by 127 · see citing works

Hypoxic Signaling During Tissue Repair and Regenerative Medicine

Nauta, T. D., van Hinsbergh, V. W. M., & Koolwijk, P. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms151119791 · Cited by 125 · see citing works

Defective development of secretory neurones in the hypothalamus of Arnt2‐knockout mice

Hosoya, T., Oda, Y., Takahashi, S., Morita, M., Kawauchi, S., Ema, M., Yamamoto, M., & Fujii‐Kuriyama, Y. (2001) · Genes to Cells · doi:10.1046/j.1365-2443.2001.00421.x · Cited by 118 · see citing works

Glucose metabolism impacts the spatiotemporal onset and magnitude of HSC induction in vivo

Harris, J. M., Esain, V., Frechette, G. M., Harris, L. J., Cox, A. G., Cortes, M., Garnaas, M., Carroll, K. J., Cutting, C. C., Khan, T. M., et al. (2013) · Blood · doi:10.1182/blood-2012-12-471201 · Cited by 116 · see citing works

HIFs, Hypoxia, and Vascular Development

Covello, K. L., & Simon, M. C. (2004) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(04)62002-3 · Cited by 113 · see citing works

HIF-Dependent Hematopoietic Factors Regulate the Development of the Embryonic Vasculature

Ramírez‐Bergeron, D. L., Runge, A., Adelman, D. M., Gohil, M., & Simon, M. C. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.04.018 · Cited by 113 · see citing works

Loss of Cited2 affects trophoblast formation and vascularization of the mouse placenta

Withington, S. L., Scott, A., Saunders, D. N., Floro, K. L., Preis, J. I., Michalicek, J., Maclean, K., Sparrow, D. B., Martı́nez-Barberá, J. P., & Dunwoodie, S. L. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.02.025 · Cited by 112 · see citing works

Hypoxic stress in diabetic pregnancy contributes to impaired embryo gene expression and defective development by inducing oxidative stress

Li, R., Chase, M., Jung, S., Smith, P. J., & Loeken, M. R. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00441.2004 · Cited by 111 · see citing works

ABL1 fusion genes in hematological malignancies: a review

Braekeleer, E. D., Douet‐Guilbert, N., Rowe, D. W., Bown, N. P., Morel, F., Berthou, C., Férec, C., & Braekeleer, M. D. (2011) · European Journal Of Haematology · doi:10.1111/j.1600-0609.2011.01586.x · Cited by 105 · see citing works

Gene expression profiling in the leukemic stem cell-enriched CD34+ fraction identifies target genes that predict prognosis in normal karyotype AML

de Jonge, H. J. M., Woolthuis, C. M., Vos, A., Mulder, A. B., van den Berg, E., Kluin, P. M., van der Weide, K., de Bont, E. S. J. M., Huls, G. A., Vellenga, E., et al. (2011) · Leukemia · doi:10.1038/leu.2011.172 · Cited by 100 · see citing works

Prolyl Hydroxylase Domain Inhibitors: A Route to HIF Activation and Neuroprotection

Harten, S. K., Ashcroft, M. A., & Maxwell, P. H. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2870 · Cited by 99 · see citing works

Role of the hypoxic bone marrow microenvironment in 5T2MM murine myeloma tumor progression.

Asosingh, K., Raeve, H. D., Ridder, M. D., Storme, G. A., Willems, A., Riet, I. V., Camp, B. V., & Vanderkerken, K. (2005) · PubMed · Cited by 98 · see citing works

Oxygen Transport and Stem Cell Aggregation in Stirred-Suspension Bioreactor Cultures

Wu, J., Rostami, M. R., Olaya, D. P. C., & Tzanakakis, E. S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0102486 · Cited by 97 · see citing works

Advances in Understanding the Molecular Causes of Diabetes-Induced Birth Defects

Loeken, M. R. (2005) · Journal of the Society for Gynecologic Investigation · doi:10.1016/j.jsgi.2005.09.007 · Cited by 96 · see citing works

Hypoxia‐Inducible Factor and the Development of Stem Cells of the Cardiovascular System

Ramírez‐Bergeron, D. L., & Simon, M. C. (2001) · Stem Cells · doi:10.1634/stemcells.19-4-279 · Cited by 95 · see citing works

Hypoxia-amplified Proliferation of Human Dental Pulp Cells

Sakdee, J. B., White, R. R., Pagonis, T. C., & Hauschka, P. V. (2009) · Journal of Endodontics · doi:10.1016/j.joen.2009.03.001 · Cited by 89 · see citing works

Oxygen, Epigenetics and Stem Cell Fate

Okazaki, K. M., & Maltepe, E. (2005) · Regenerative Medicine · doi:10.2217/17460751.1.1.71 · Cited by 86 · see citing works

The t(1;12)(q21;p13) translocation of human acute myeloblastic leukemia results in a TEL-ARNT fusion

Nguyen‐Khac, F., Della-Valle, V., Mauchauffé, M., Coniat, M. L., Ghysdael, J., Berger, R., & Bernard, O. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.120162297 · Cited by 85 · see citing works

HIF1α is a regulator of hematopoietic progenitor and stem cell development in hypoxic sites of the mouse embryo

Imanirad, P., Kartalaei, P. S., Crisan, M., Vink, C. S., Yamada-Inagawa, T., de Pater, E., Kurek, D., Kaimakis, P., van der Linden, R., Speck, N. A., et al. (2013) · Stem Cell Research · doi:10.1016/j.scr.2013.09.006 · Cited by 83 · see citing works

Predicting CTCF-mediated chromatin interactions by integrating genomic and epigenomic features

Yan, K., Andricovich, J., Zeng, Z., Zhu, J., Tzatsos, A., & Peng, W. (2018) · Nature Communications · doi:10.1038/s41467-018-06664-6 · Cited by 73 · see citing works

Metabolism and the leukemic stem cell

Abdel-Wahab, O. I., & Levine, R. L. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20100523 · Cited by 74 · see citing works

Hypoxia regulates the hematopoietic stem cell niche

Morikawa, T., & Takubo, K. (2015) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-015-1743-z · Cited by 72 · see citing works

Role of HIF Signaling on Tumorigenesis in Response to Chronic Low-Dose Arsenic Administration

Kamat, C. D., Green, D. E., Curilla, S., Warnke, L. A., Hamilton, J. W., Stürup, S., Clark, C., & Ihnat, M. A. (2005) · Toxicological Sciences · doi:10.1093/toxsci/kfi190 · Cited by 72 · see citing works

Isolation and characterization of AINT: a novel ARNT interacting protein expressed during murine embryonic development

Sadek, C. M., Jalaguier, S., Feeney, E. P., Aitola, M., Damdimopoulos, A. E., Pelto‐Huikko, M., & Gustafsson, J.-Å. (2000) · Mechanisms of Development · doi:10.1016/s0925-4773(00)00415-9 · Cited by 72 · see citing works

Metastasis and stem cell pathways

Barnhart, B. C., & Simon, M. C. (2007) · Cancer and Metastasis Reviews · doi:10.1007/s10555-007-9053-3 · Cited by 71 · see citing works

Cloning, expression analysis, and chromosomal localization of murine and human homologues of aXenopus Mix gene

Robb, L. G., Hartley, L., Begley, C. G., Brodnicki, T. C., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., & Elefanty, A. G. (2000) · Developmental Dynamics · doi:10.1002/1097-0177(2000)9999:9999 · Cited by 78 · see citing works

Coactivators necessary for transcriptional output of the hypoxia inducible factor, HIF, are directly recruited by ARNT PAS-B

Partch, C. L., & Gardner, K. H. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1101357108 · Cited by 65 · see citing works

Inflammation and Prostate Cancer

Tewari, A. K., Stockert, J. A., Yadav, S. S., Yadav, K. K., & Khan, I. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-95693-0_3 · Cited by 63 · see citing works

Therapeutic targeting of the HIF oxygen-sensing pathway: Lessons learned from clinical studies

Haase, V. H. (2017) · Experimental Cell Research · doi:10.1016/j.yexcr.2017.05.004 · Cited by 64 · see citing works

Hypoxia. 5. Hypoxia and hematopoiesis

Yoon, D., Ponka, P., & Prchal, J. T. (2011) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00044.2011 · Cited by 61 · see citing works

Hypoxia enhances human B19 erythrovirus gene expression in primary erythroid cells

Pillet, S., Guyader, N. L., Höfer, T., Nguyen‐Khac, F., Koken, M. H. M., Aubin, J., Fichelson, S., Gassmann, M., & Morinet, F. (2004) · Virology · doi:10.1016/j.virol.2004.06.020 · Cited by 60 · see citing works

Cited2 is required for normal hematopoiesis in the murine fetal liver

Chen, Y., Haviernik, P., Bunting, K. D., & Yang, Y. (2007) · Blood · doi:10.1182/blood-2007-01-066316 · Cited by 59 · see citing works

Loss of the Birt–Hogg–Dubé tumor suppressor results in apoptotic resistance due to aberrant TGFβ-mediated transcription

Cash, T. P., Gruber, J. J., Hartman, T. R., Henske, E. P., & Simon, M. C. (2011) · Oncogene · doi:10.1038/onc.2010.628 · Cited by 59 · see citing works

Endothelium-Intrinsic Requirement for Hif-2 α During Vascular Development

Duan, L., Zhang‐Benoit, Y., & Fong, G. (2005) · Circulation · doi:10.1161/01.cir.0000163580.98098.a3 · Cited by 60 · see citing works

New development of the yolk sac theory in diabetic embryopathy: molecular mechanism and link to structural birth defects

Dong, D., Reece, E. A., Lin, X., Wu, Y., AriasVillela, N., & Yang, P. (2015) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2015.09.082 · Cited by 63 · see citing works

From stem cells to cancer stem cells: HIF takes the stage

Lee, K. E., & Simon, M. C. (2012) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2012.01.005 · Cited by 57 · see citing works

MT1-MMP plays a critical role in hematopoiesis by regulating HIF-mediated chemokine/cytokine gene transcription within niche cells

Nishida, C., Kusubata, K., Tashiro, Y., Gritli, I., Sato, A., Ohki, M., Morita, Y., Nagano, M., Sakamoto, T., Koshikawa, N., et al. (2012) · Blood · doi:10.1182/blood-2011-11-390849 · Cited by 56 · see citing works

Metabolic circuits in neural stem cells

Kim, D., Rhee, I., & Paik, J. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1686-0 · Cited by 56 · see citing works

Hypoxia and HIFs in regulating the development of the hematopoietic system

Imanirad, P., & Dzierzak, E. A. (2013) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2013.08.005 · Cited by 54 · see citing works

A Knock-in Mouse Model of Human PHD2 Gene-associated Erythrocytosis Establishes a Haploinsufficiency Mechanism

Arsenault, P. R., Pei, F., Lee, R., Kerestes, H., Percy, M. J., Keith, B., Simon, M. C., Lappin, T. R. J., Khurana, T. S., & Lee, F. S. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.482364 · Cited by 54 · see citing works

Hypoxia Influences the Vascular Expansion and Differentiation of Embryonic Stem Cell Cultures Through the Temporal Expression of Vascular Endothelial Growth Factor Receptors in an ARNT-Dependent Manner

Han, Y., Kuang, S.-Z., Gomer, A., & Ramírez‐Bergeron, D. L. (2010) · Stem Cells · doi:10.1002/stem.316 · Cited by 48 · see citing works

Targeted ablation of Arnt in mouse epidermis results in profound defects in desquamation and epidermal barrier function

Geng, S., Mezentsev, A., Kalachikov, S. M., Raith, K., Roop, D. R., & Panteleyev, A. A. (2006) · Journal of Cell Science · doi:10.1242/jcs.03282 · Cited by 48 · see citing works

Hypoxia-Inducible Factors and Kidney Vascular Development

Freeburg, P. B., & Abrahamson, D. R. (2003) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000092794.37534.01 · Cited by 47 · see citing works

Lung Vascular Development

Stenmark, K. R., & Gebb, S. A. (2003) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.f259 · Cited by 47 · see citing works

Roles of the hypoxia response system in hematopoietic and leukemic stem cells

Takubo, K., & Suda, T. (2012) · International Journal of Hematology · doi:10.1007/s12185-012-1071-4 · Cited by 46 · see citing works

The aryl hydrocarbon receptor nuclear translocator is an essential regulator of murine hematopoietic stem cell viability

Krock, B. L., Eisinger‐Mathason, T. S. K., Giannoukos, D. N., Shay, J. E. S., Gohil, M., Lee, D. S. M., Nakazawa, M. S., Sesen, J., Skuli, N., & Simon, M. C. (2015) · Blood · doi:10.1182/blood-2014-10-607267 · Cited by 43 · see citing works

Thrombopoietin (TPO) regulates HIF-1α levels through generation of mitochondrial reactive oxygen species

Yoshida, K., Kirito, K., Hu, Y., Ozawa, K., Kaushansky, K., & Komatsu, N. (2008) · International Journal of Hematology · doi:10.1007/s12185-008-0091-6 · Cited by 44 · see citing works

The kidney papilla is a stem cells niche

Al‐Awqati, Q., & Oliver, J. A. (2006) · Stem Cell Reviews and Reports · doi:10.1007/s12015-006-0046-3 · Cited by 42 · see citing works

Lasting longer without oxygen: The influence of hypoxia on Notch signaling

Pear, W. S., & Simon, M. C. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.11.016 · Cited by 41 · see citing works

Targeting the Hypoxia-Sensing Pathway in Clinical Hematology

Forristal, C. E., & Lévesque, J.-P. (2013) · Stem Cells Translational Medicine · doi:10.5966/sctm.2013-0134 · Cited by 41 · see citing works

Activation of Hypoxic Response in Human Embryonic Stem Cell–Derived Embryoid Bodies

Cameron, C. M., Harding, F. J., Hu, W., & Kaufman, D. S. (2008) · Experimental Biology and Medicine · doi:10.3181/0709-rm-263 · Cited by 40 · see citing works

Hypoxia-inducible factor (HIF) and HIF-stabilizing agents in neonatal care

Park, A. M., Sanders, T. A., & Maltepe, E. (2010) · Seminars in Fetal and Neonatal Medicine · doi:10.1016/j.siny.2010.05.006 · Cited by 40 · see citing works

Hypoxia affects mesoderm and enhances hemangioblast specification during early development

Ramírez‐Bergeron, D. L., Runge, A., Dahl, K. D. C., Fehling, H. J., Keller, G. M., & Simon, M. C. (2004) · Development · doi:10.1242/dev.01310 · Cited by 151 · see citing works

Hypoxia Influences the Vascular Expansion and Differentiation of Embryonic Stem Cell Cultures Through the Temporal Expression of Vascular Endothelial Growth Factor Receptors in an ARNT-Dependent Manner

Han, Y., Kuang, S.-Z., Gomer, A., & Ramírez‐Bergeron, D. L. (2010) · Stem Cells · doi:10.1002/stem.316 · Cited by 48 · see citing works

HIF-Dependent Hematopoietic Factors Regulate the Development of the Embryonic Vasculature

Ramírez‐Bergeron, D. L., Runge, A., Adelman, D. M., Gohil, M., & Simon, M. C. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.04.018 · Cited by 113 · see citing works

ARNT

Mak, T. W., Penninger, J. M., Roder, J., Rossant, J., & Saunders, M. E. (1998) · Elsevier eBooks · doi:10.1016/b978-012466044-1/50030-2

Regulation of Hypoxic Genes in Differentiating Stem Cells

Mack, F. A., & Simon, M. C. (2004) · Elsevier eBooks · doi:10.1016/b978-012436643-5/50016-x