The DOI matches its Crossref record; 47 of the 49 references it cites were found in a registry or an index.
Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase
Open accessAbstract
MAP kinases phosphorylate specific groups of substrate proteins.Here we show that the amino acid sequence FXFP is an evolutionarily conserved docking site that mediates ERK MAP kinase binding to substrates in multiple protein families.FXFP and the D box, a different docking site, form a modular recognition system, as they can function independently or in combination.FXFP is specific for ERK, whereas the D box mediates binding to ERK and JNK MAP kinase, suggesting that the partially overlapping substrate specificities of ERK and JNK result from recognition of shared and unique docking sites.These findings enabled us to predict new ERK substrates and design peptide inhibitors of ERK that functioned in vitro and in vivo.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Moreover, the existence of FxFP (Phe-any amino acid-Phe-Pro) motifs in certain MAPK (especially ERK) substrates and a separate docking groove for such motifs on ERK suggest that in some cases two docking grooves on ERK may operate in combination: Elk1 for example contains both an FxFP and a D-motif (35-37).”
From Specificity of Linear Motifs That Bind to a Common Mitogen-Activated Protein Kinase Docking Groove (2012) · cites this paper as [37]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Molecular cloning: A laboratory manual
Deininger, P. L. (1990) · Analytical Biochemistry · doi:10.1016/0003-2697(90)90595-z · Cited by 84,684
Oncogenes and signal transduction
Cantley, L. C., Auger, K. R., Carpenter, C. F., Duckworth, B. C., Graziani, A., Kapeller, R., & Soltoff, S. P. (1991) · Cell · doi:10.1016/0092-8674(91)90639-g · Cited by 2,697
The mitogen-activated protein kinase signal transduction pathway
Davis, R. J. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)82362-6 · Cited by 2,112
Hibi, M., Lin, A., Smeal, T., Minden, A., & Karin, M. (1993) · Genes & Development · doi:10.1101/gad.7.11.2135 · Cited by 1,886
Whitmarsh, A. J., & Davis, R. J. (1996) · Journal of Molecular Medicine · doi:10.1007/s001090050063 · Cited by 1,543
Regulation of transcription by MAP kinase cascades
Treisman, R. (1996) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(96)80067-6 · Cited by 1,296
The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain
Marais, R., Wynne, J., & Treisman, R. (1993) · Cell · doi:10.1016/0092-8674(93)90237-k · Cited by 1,275
MAP kinase kinase kinase, MAP kinase kinase and MAP kinase
Marshall, C. J. (1994) · Current Opinion in Genetics & Development · doi:10.1016/0959-437x(94)90095-7 · Cited by 1,005
Activation mechanism of the MAP kinase ERK2 by dual phosphorylation
Canagarajah, B. J., Khokhlatchev, A., Cobb, M. H., & Goldsmith, E. J. (1997) · Cell · doi:10.1016/s0092-8674(00)80351-7 · Cited by 729
Ternary complex factors: growth factor regulated transcriptional activators
Treisman, R. (1994) · Current Opinion in Genetics & Development · doi:10.1016/0959-437x(94)90097-3 · Cited by 676
Kallunki, T., Su, B., Tsigelny, I., Sluss, H. K., Dérijard, B., Moore, G., Davis, R., & Karin, M. (1994) · Genes & Development · doi:10.1101/gad.8.24.2996 · Cited by 642
Songyang, Z., Lu, K. P., Kwon, Y. T., Tsai, L., Filhol, O., Cochet, C., Brickey, D. A., Soderling, T. R., Bartleson, C., Graves, D. J., et al. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.11.6486 · Cited by 550
c-Jun Can Recruit JNK to Phosphorylate Dimerization Partners via Specific Docking Interactions
Kallunki, T., Deng, T., Hibi, M., & Karin, M. (1996) · Cell · doi:10.1016/s0092-8674(00)81999-6 · Cited by 492
Regulation and function of the JNK subgroup of MAP kinases
Minden, A., & Karin, M. (1997) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(97)00018-8 · Cited by 486
Sturgill, T. W., & Wu, J. (1991) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(97)90012-4 · Cited by 430
GATA transcription factors: key regulators of hematopoiesis.
Weiss, M. J., & Orkin, S. H. (1995) · PubMed · Cited by 415
Adams, P. D., Sellers, W. R., Sharma, S. K., Wu, A. D., Nalin, C. M., & Kaelin, W. G. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.12.6623 · Cited by 380
KSR, a novel protein kinase required for RAS signal transduction
Therrien, M., Chang, H. C., Solomon, N. M., Karim, F. D., Wassarman, D. A., & Rubin, G. M. (1995) · Cell · doi:10.1016/0092-8674(95)90204-x · Cited by 340
The regulation of AP-1 activity by mitogen-activated protein kinases
Karin, M., & Marshall, C. J. (1996) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1996.0008 · Cited by 334
Sundaram, M. V., & Han, M. (1995) · Cell · doi:10.1016/0092-8674(95)90205-8 · Cited by 307
The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans
Kornfeld, K., Hom, D. B., & Horvitz, H. R. (1995) · Cell · doi:10.1016/0092-8674(95)90206-6 · Cited by 302
Self-citationDifferential targeting of MAP kinases to the ETS‐domain transcription factor Elk‐1
Yang, S., Whitmarsh, A. J., Davis, R. J., & Sharrocks, A. D. (1998) · The EMBO Journal · doi:10.1093/emboj/17.6.1740 · Cited by 299
The riddle of MAP kinase signaling specificity
Madhani, H. D., & Fink, G. R. (1998) · Trends in Genetics · doi:10.1016/s0168-9525(98)01425-5 · Cited by 293
Comparative analysis of the ternary complex factors Elk‐1, SAP‐1a and SAP‐2 (ERP/NET).
Price, M. A., Rogers, A. F., & Treisman, R. (1995) · EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07257.x · Cited by 274
Yang, S., Yates, P. R., Whitmarsh, A. J., Davis, R. J., & Sharrocks, A. D. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.2.710 · Cited by 255
Cook, J. G., Bardwell, L., Kron, S. J., & Thorner, J. W. (1996) · Genes & Development · doi:10.1101/gad.10.22.2831 · Cited by 221
Tan, P. B. O., Lackner, M. R., & Kim, S. K. (1998) · Cell · doi:10.1016/s0092-8674(00)81186-1 · Cited by 202
Regulation of the MAP kinase pathway by mammalian Ksr through direct interaction with MEK and ERK
Yu, W., Fantl, W. J., Harrowe, G., & Williams, L. T. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70020-x · Cited by 197
Deshpande, A. K., & Kung, H. F. (1987) · Molecular and Cellular Biology · doi:10.1128/mcb.7.3.1285 · Cited by 181
The protein kinase KSR interacts with 14-3-3 protein and Raf
Xing, H., Kornfeld, K., & Muslin, A. J. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00152-7 · Cited by 173
Self-citationBeitel, G. J., Tuck, S., Greenwald, I., & Horvitz, H. R. (1995) · Genes & Development · doi:10.1101/gad.9.24.3149 · Cited by 161
Bardwell, L., Cook, J. G., Chang, E. C., Cairns, B. R., & Thorner, J. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.7.3637 · Cited by 161
[29] Assay and expression of mitogen-activated protein kinase, MAP kinase kinase, and Raf
Alessi, D. R., Cohen, P., Ashworth, A., Cowley, S. A., Leevers, S. J., & Marshall, C. J. (1995) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(95)55031-3 · Cited by 158
Adler, V., Franklin, C. C., & Kraft, A. S. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.12.5341 · Cited by 140
Matsuda, S., Gotoh, Y., & Nishida, E. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53690-5 · Cited by 126
Lopez, M., Oettgen, P., Akbarali, Y., Dendorfer, U., & Libermann, T. A. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.5.3292 · Cited by 118
Muslin, A. J., MacNicol, A. M., & Williams, L. T. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.7.4197 · Cited by 116
Self-citationJacobs, D., Beitel, G. J., Clark, S. G., Horvitz, H. R., & Kornfeld, K. (1998) · Genetics · doi:10.1093/genetics/149.4.1809 · Cited by 109
Self-citation1 MAP Kinases in Mitogenesis and Development
Ferrell, J. E. (1996) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(08)60336-1 · Cited by 103
Regulation of GATA-2 Phosphorylation by Mitogen-activated Protein Kinase and Interleukin-3
Towatari, M., May, G. E., Marais, R., Perkins, G. R., Marshall, C. J., Cowley, S. A., & Enver, T. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.8.4101 · Cited by 101
Bardwell, L. (1996) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(96)30032-7 · Cited by 95
Regulation of Cardiac Gene Expression by GATA-4/5/6
Evans, T. (1997) · Trends in Cardiovascular Medicine · doi:10.1016/s1050-1738(97)00010-8 · Cited by 74
Cuozzo, J. W., Tao, K. X., Cygler, M., Mort, J. S., & Sahagian, G. G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.33.21067 · Cited by 62
Regulation of Growth Factor-Induced Signaling by Protein-Tyrosine-Phosphatases
Byon, J. C. H., Kenner, K. A., Kusari, A. B., & Kusari, J. (1997) · Experimental Biology and Medicine · doi:10.3181/00379727-216-44153 · Cited by 47
Nebreda, Á. R., Porrás, A., & Santos, E. (1993) · PubMed · Cited by 46
raf oncogenes in carcinogenesis.
Storm, S. M., Brennscheidt, U., Sithanandam, G., & Rapp, U. R. (1990) · PubMed · Cited by 28
(1994) · Trends in Genetics · doi:10.1016/0168-9525(94)90051-5 · Cited by 12
Flagged first, then by citations
2 of the 49 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions*
Pearson, G. W., Robinson, F. L., Gibson, T. B., Xu, B.-E., Karandikar, M. S., Berman, K. S., & Cobb, M. H. (2001) · Endocrine Reviews · doi:10.1210/edrv.22.2.0428 · Cited by 4,111
Hunter, T. (2000) · Cell · doi:10.1016/s0092-8674(00)81688-8 · Cited by 2,586
Roux, P. P., & Blenis, J. (2004) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.68.2.320-344.2004 · Cited by 2,540
ERK1/2 MAP kinases: Structure, function, and regulation
Roskoski, R. J. (2012) · Pharmacological Research · doi:10.1016/j.phrs.2012.04.005 · Cited by 1,719
Mechanisms of specificity in protein phosphorylation
Ubersax, J. A., & Ferrell Jr, J. E. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2203 · Cited by 1,451
Metadata
- Authors
- Jacobs, D., Glossip, D., Xing, H., Muslin, A. J., & Kornfeld, K.
- Affiliations
- Washington University in St. Louis (US)
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1999-01-15
- Volume
- 13
- Issue
- 2
- Pages
- 163-175
- ISSN
- 0890-9369 (ISSN-L)
- OpenAlex
- W4239714346
- Cited by
- 439
- References
- 49
- Citations by year
- 2026: 8 · 2025: 6 · 2024: 4 · 2023: 9 · 2022: 16 · 2021: 12 · 2020: 13 · 2019: 7 · 2018: 13 · 2017: 13 · 2016: 16 · 2015: 15 · 2014: 10 · 2013: 13 · 2012: 15
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- Funders
- Burroughs Wellcome Fund
- Foundation for Barnes-Jewish Hospital
- Edward Mallinckrodt, Jr. Foundation
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
- Keywords
- ERK MAP kinase, docking site, D-box, substrate specificity, JNK MAP kinase, phosphorylation, peptide inhibitors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review