Cited by 440Melanoma and MAPK PathwaysProtein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

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Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase

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Jacobs, D., Glossip, D., Xing, H., Muslin, A. J., Kornfeld, K.·1999·Genes & Development

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Abstract

MAP kinases phosphorylate specific groups of substrate proteins.Here we show that the amino acid sequence FXFP is an evolutionarily conserved docking site that mediates ERK MAP kinase binding to substrates in multiple protein families.FXFP and the D box, a different docking site, form a modular recognition system, as they can function independently or in combination.FXFP is specific for ERK, whereas the D box mediates binding to ERK and JNK MAP kinase, suggesting that the partially overlapping substrate specificities of ERK and JNK result from recognition of shared and unique docking sites.These findings enabled us to predict new ERK substrates and design peptide inhibitors of ERK that functioned in vitro and in vivo.

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Authors: Jacobs, D., Glossip, D., Xing, H., Muslin, A. J., & Kornfeld, K.
Affiliations: Washington University in St. Louis (US)
ORCID: Xing, H.
Muslin, A. J.
Kornfeld, K.
Venue: Genes & Development
Publisher: Cold Spring Harbor Laboratory
Published: 1999-01-15
Volume: 13
Issue: 2
Pages: 163-175
ISSN: 0890-9369 (ISSN-L)
DOI: 10.1101/gad.13.2.163
OpenAlex: W4239714346
Cited by: 439
References: 49
Citations by year: 2026: 8 · 2025: 6 · 2024: 4 · 2023: 9 · 2022: 16 · 2021: 12 · 2020: 13 · 2019: 7 · 2018: 13 · 2017: 13 · 2016: 16 · 2015: 15 · 2014: 10 · 2013: 13 · 2012: 15
Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Genes & Development (publishedVersion)
Funders: Burroughs Wellcome Fund
Foundation for Barnes-Jewish Hospital
Edward Mallinckrodt, Jr. Foundation
National Institutes of Health
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
Keywords: ERK MAP kinase, docking site, D-box, substrate specificity, JNK MAP kinase, phosphorylation, peptide inhibitors

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Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase

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