The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The glucocorticoid receptor is required for stress erythropoiesis
Open accessAbstract
The glucocorticoid receptor (GR) coordinates a multitude of physiological responses in vivo. In vitro, glucocorticoids are required for sustained proliferation of erythroid progenitors (ebls). Here, we analyze the impact of the GR on erythropoiesis in vivo, using GR-deficient mice or mice expressing a GR defective for transactivation. In vitro, sustained proliferation of primary ebls requires an intact GR. In vivo, the GR is required for rapid expansion of ebls under stress situations like erythrolysis or hypoxia. A particular, GR-sensitive progenitor could be identified as being responsible for the stress response. Thus, GR-mediated regulation of ebl proliferation is essential for stress erythropoiesis in vivo.
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Cites
Stress hormones: their interaction and regulation
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DNA binding of the glucocorticoid receptor is not essential for survival
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Self-citation
Cited by
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Hattangadi, S. M., Wong, P., Zhang, L., Flygare, J., & Lodish, H. F. (2011) · Blood · doi:10.1182/blood-2011-07-356006 · Cited by 423
The miR-144/451 locus is required for erythroid homeostasis
Rasmussen, K. D., Simmini, S., Abreu-Goodger, C., Bartonicek, N., Di Giacomo, M., Bilbao-Cortes, D., Horos, R., Von Lindern, M., Enright, A. J., & O’Carroll, D. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20100458 · Cited by 330
Anaemia in kidney disease: harnessing hypoxia responses for therapy
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Kassel, O., & Herrlich, P. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2007.07.003 · Cited by 277
Tuckermann, J. P., Kleiman, A., Moriggl, R., Spanbroek, R., Neumann, A., Illing, A., Clausen, B. E., Stride, B., Förster, I., Habenicht, A. J. R., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci28034 · Cited by 252
PU.1 determines the self-renewal capacity of erythroid progenitor cells
Back, J., Dierich, A., Bronn, C., Kastner, P., & Chan, S. (2004) · Blood · doi:10.1182/blood-2003-11-4089 · Cited by 123
Potentiation of Glucocorticoid Activity in Hypoxia through Induction of the Glucocorticoid Receptor
Leonard, M. O., Godson, C., Brady, H. R., & Taylor, C. T. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.4.2250 · Cited by 100
Kiank, C., Holtfreter, B., Starke, A., Mundt, A., Wilke, C., & Schütt, C. (2006) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2005.10.151 · Cited by 76
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Molecular Genetic Analysis of Glucocorticoid Signaling Using the Cre/loxP System
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Self-citationEiers, A.-K., Vettorazzi, S., & Tuckermann, J. P. (2024) · Annals of the Rheumatic Diseases · doi:10.1136/ard-2023-225371 · Cited by 31
Erythrocyte survival is controlled by microRNA-142
Rivkin, N., Chapnik, E., Mildner, A., Barshtein, G., Porat, Z., Kartvelishvily, E., Dadosh, T., Birger, Y., Amir, G., Yedgar, S., et al. (2017) · Haematologica · doi:10.3324/haematol.2016.156109 · Cited by 31
Metadata
- Authors
- Bauer, A., Tronche, F., Wessely, O., Kellendonk, C., Reichardt, H. M., Steinlein, P., Schutz, G., & Beug, H.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1999-11-15
- Volume
- 13
- Issue
- 22
- Pages
- 2996-3002
- ISSN
- 0890-9369 (ISSN-L)
- OpenAlex
- W2020693727
- Cited by
- 296
- References
- 3
- Type
- posted content
- Language
- en
- Open access
- diamond
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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