Glucocorticoids and circadian clock control of cell proliferation: At the interface between three dynamic systems
Open accessAbstract
The circadian clock, an endogenous timekeeper that regulates daily rhythms of physiology, also influences the dynamic release of glucocorticoids. The release of glucocorticoids is characteristically pulsatile and is further modulated in a circadian fashion. A circadian pacemaker in the brain regulates daily rhythms of hypothalamic-pituitary-adrenal axis and autonomic nervous system activity that both influence glucocorticoid release from the adrenal gland. This systemic regulation interacts with rhythms in the adrenal gland itself that are driven by its own circadian clock. One function of glucocorticoids is the regulation of cell proliferation. Depending on the tissue, this can involve both negative and positive regulation of a variety of processes, including cell differentiation and cell death. Cell proliferation is also under circadian control, and recent evidence suggests that this regulation may involve glucocorticoid signalling. Here, we review the dynamic processes participating in the interplay between the circadian clock, glucocorticoids and cell proliferation, and we discuss the potential implications for therapy.
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The ultradian pattern is caused by intrinsic dynamics of the HPA axis itself.
“It is generally believed that the circadian pattern is modulated by exogenous factors such as daylight, temperature, psychological as well as physical stress, but that the ultradian pattern is caused by intrinsic dynamics of the HPA axis itself [13, 19, 32, 36, 54].”
From Patient specific modeling of the HPA axis related to clinical diagnosis of depression (2017) · cites this paper as [13]
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- Authors
- Dickmeis, T., & Foulkes, N. S.
- Affiliations
- Karlsruhe Institute of Technology (DE)
- Corresponding author
- Dickmeis, Thomas
- Venue
- Molecular and Cellular Endocrinology
- Publisher
- Elsevier BV
- Published
- 2011-01-01
- Volume
- 331
- Issue
- 1
- Pages
- 11-22
- ISSN
- 0303-7207 (ISSN-L)
- OpenAlex
- W2092138635
- Cited by
- 47
- References
- 17
- Citations by year
- 2026: 1 · 2025: 1 · 2021: 1 · 2020: 3 · 2019: 4 · 2018: 1 · 2017: 5 · 2016: 4 · 2015: 7 · 2014: 5 · 2013: 6 · 2012: 6
- FWCI
- 2.18
- Type
- journal article
- Language
- en
- Open access
- green
- hal.science
- Licence
- Locations
- Molecular and Cellular Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- Trinity's Access to Research Output (TARA) (Trinity College Dublin) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Keywords
- glucocorticoids, circadian clock, cell proliferation, circadian rhythm, hypothalamic-pituitary-adrenal axis, glucocorticoid signaling, cell differentiation, cell death, autonomic nervous system
- MeSH terms
- Adrenal Glands, Animals, Circadian Rhythm, Glucocorticoids, Humans, Neoplasms, Cell Proliferation, Neurogenesis, Circadian Clocks
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