Cited by 341PI3K/AKT/mTOR signaling in cancerProtein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase Signaling

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SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival

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Liu, Q., Sasaki, T., Kozieradzki, I., Wakeham, A., Itie, A., Dumont, D. J., Penninger, J. M.·1999·Genes & Development

DOI 10.1101/gad.13.7.786PMC PMC316591

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Abstract

SHIP is an inositol 5' phosphatase that hydrolyzes the PI3'K product PI(3,4,5)P3. We show that SHIP-deficient mice exhibit dramatic chronic hyperplasia of myeloid cells resulting in splenomegaly, lymphadenopathy, and myeloid infiltration of vital organs. Neutrophils and bone marrow-derived mast cells from SHIP-/- mice are less susceptible to programmed cell death induced by various apoptotic stimuli or by growth factor withdrawal. Engagement of IL3-R and GM-CSF-R in these cells leads to increased and prolonged PI3'K-dependent PI(3,4,5)P3 accumulation and PKB activation. These data indicate that SHIP is a negative regulator of growth factor-mediated PKB activation and myeloid cell survival.

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Authors: Liu, Q., Sasaki, T., Kozieradzki, I., Wakeham, A., Itie, A., Dumont, D. J., & Penninger, J. M.
Affiliations: University of Toronto (CA)
ORCID: Liu, Q.
Sasaki, T.
Kozieradzki, I.
Dumont, D. J.
Penninger, J. M.
Venue: Genes & Development
Publisher: Cold Spring Harbor Laboratory
Published: 1999-04-01
Volume: 13
Issue: 7
Pages: 786-791
ISSN: 0890-9369 (ISSN-L)
DOI: 10.1101/gad.13.7.786
PMC: PMC316591
OpenAlex: W2151313755
Cited by: 341
References: 31
Citations by year: 2026: 1 · 2025: 4 · 2024: 7 · 2023: 12 · 2022: 5 · 2021: 4 · 2020: 5 · 2019: 3 · 2018: 10 · 2017: 8 · 2016: 9 · 2015: 7 · 2014: 10 · 2013: 14 · 2012: 17
Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Genes & Development (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Keywords: ships, inositol polyphosphate 5-phosphatase, phosphatidylinositol 3-kinase, phosphatidylinositol 3,4,5-trisphosphate, Akt signaling, apoptosis, GM-CSF receptor, growth factor withdrawal, myeloid hyperplasia, splenomegaly, mast cells, neutrophils
MeSH terms: Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases, Animals, Anisomycin, Bone Marrow, Cell Line, Cell Survival, Cycloheximide, Enzyme Activation, Interleukin-3, Mice, Inbred C57BL, Neutrophils, Phosphoric Monoester Hydrolases, Precipitin Tests, Proto-Oncogene Proteins, Sorbitol, Spleen, Time Factors, Blotting, Southern, Blotting, Western, Down-Regulation, Apoptosis, Protein Serine-Threonine Kinases, Mice, Knockout, Proto-Oncogene Proteins c-akt, Mice

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SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival

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