p53 isoforms can regulate p53 transcriptional activity

Antibodies, a laboratory manual

(1989) · Biomedicine & Pharmacotherapy · doi:10.1016/0753-3322(89)90130-3 · Cited by 12,318

T antigen is bound to a host protein in SY40-transformed cells

Lane, D. P., & Crawford, L. V. (1979) · Nature · doi:10.1038/278261a0 · Cited by 2,456

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

Linzer, D. I. H., & Levine, A. J. (1979) · Cell · doi:10.1016/0092-8674(79)90293-9 · Cited by 1,814

p53 mutant mice that display early ageing-associated phenotypes

Tyner, S. D., Venkatachalam, S., Choi, J., Jones, S., Ghebranious, N., Igelmann, H., Lu, X., Soron, G., Cooper, B., Brayton, C., et al. (2002) · Nature · doi:10.1038/415045a · Cited by 1,459

Decision making by p53: life, death and cancer

Oren, M. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401183 · Cited by 1,085

Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse.

DeLeo, A. B., Jay, G. D., Appella, E., DuBois, G. C., Law, L. W., & Old, L. J. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.5.2420 · Cited by 721

Modulation of mammalian life span by the short isoform of p53

Maier, B., Gluba, W., Bernier, B., Turner, T., Mohammad, K., Guise, T., Sutherland, A., Thorner, M., & Scrable, H. (2004) · Genes & Development · doi:10.1101/gad.1162404 · Cited by 586

Mdm2-Mediated NEDD8 Conjugation of p53 Inhibits Its Transcriptional Activity

Xirodimas, D. P., Saville, M. K., Bourdon, J.-C., Hay, R. T., & Lane, D. P. (2004) · Cell · doi:10.1016/j.cell.2004.06.016 · Cited by 570

On the shoulders of giants: p63, p73 and the rise of p53

Yang, A., Kaghad, M., Caput, D., & McKeon, F. (2002) · Trends in Genetics · doi:10.1016/s0168-9525(02)02595-7 · Cited by 496

Drosophila p53 Binds a Damage Response Element at the reaper Locus

Brodsky, M. H., Nordstrom, W., Tsang, G., Kwan, E., Rubin, G. M., & Abrams, J. (2000) · Cell · doi:10.1016/s0092-8674(00)80627-3 · Cited by 474

Zebrafish Models of p53 FunctionsPreprint

Storer, N. Y., & Zon, L. I. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a001123 · Cited by 67

The role of p63 in germ cell apoptosis in the developing testis

Petre‐Lazar, B., Livera, G., Moreno, S. G., Trautmann, E., Duquenne, C., Hanoux, V., Habert, R., & Coffigny, H. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20829 · Cited by 66

The p53 Isoform Δ133p53β Promotes Cancer Stem Cell Potential

Arsic, N., Gadéa, G., Lagerqvist, E. L., Busson, M., Cahuzac, N., Brock, C., Hollande, F., Gire, V., Pannequin, J., & Roux, P. (2015) · Stem Cell Reports · doi:10.1016/j.stemcr.2015.02.001 · Cited by 66

RUNX3 Modulates DNA Damage-mediated Phosphorylation of Tumor Suppressor p53 at Ser-15 and Acts as a Co-activator for p53

Yamada, C., Ozaki, T., Ando, K., Suenaga, Y., Inoue, K., Ito, Y., Okoshi, R., Kageyama, H., Kimura, H., Miyazaki, M., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.055525 · Cited by 65

p53–RNA interactions: New clues in an old mystery

Riley, K. J.-L., & Maher, L. J. (2007) · RNA · doi:10.1261/rna.673407 · Cited by 68

Role of p53 circuitry in tumorigenesis: A brief review

Niazi, S., Purohit, M., & Niazi, J. H. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.08.099 · Cited by 65

Emerging Non-Canonical Functions and Regulation by p53: p53 and Stemness

Olivos, D. J., & Mayo, L. D. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17121982 · Cited by 67

Simvastatin induced HCT116 colorectal cancer cell apoptosis through p38MAPK-p53-survivin signaling cascade

Chang, H.-L., Chen, C., Hsu, Y.-F., Kuo, W.-S., Ou, G., Chiu, P.-T., Huang, Y., & Hsu, M. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.04.011 · Cited by 68

The history of p53

Soussi, T. (2010) · EMBO Reports · doi:10.1038/embor.2010.159 · Cited by 64

Aberrant splicing in B-cell acute lymphoblastic leukemia

Black, K. L., Naqvi, A. S., Asnani, M., Hayer, K. E., Yang, S. Y., Gillespie, E. B., Bagashev, A., Pillai, V., Tasian, S. K., Gazzara, M. R., et al. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky946 · Cited by 61

p53 Downregulates Its Activating Vaccinia-Related Kinase 1, Forming a New Autoregulatory Loop

Valbuena, A., Vega, F. M. D. L., Blanco, S., & Lazo, P. A. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00069-06 · Cited by 63

Correlation analysis of p53 protein isoforms with NPM1/FLT3 mutations and therapy response in acute myeloid leukemia

Ånensen, N., Hjelle, S. M., Belle, W. V., Haaland, I., Silden, E., Bourdon, J., Hovland, R., Taskén, K., Knappskog, S., Lønning, P. E., et al. (2011) · Oncogene · doi:10.1038/onc.2011.348 · Cited by 67

p63: Defining roles in morphogenesis, homeostasis, and neoplasia of the epidermis

King, K. E., & Weinberg, W. C. (2007) · Molecular Carcinogenesis · doi:10.1002/mc.20337 · Cited by 63

Urodele p53 tolerates amino acid changes found in p53 variants linked to human cancer

Villiard, É., Brinkmann, H., Moiseeva, O. V., Mallette, F. A., Ferbeyre, G., & Roy, S. (2007) · BMC Evolutionary Biology · doi:10.1186/1471-2148-7-180 · Cited by 61

TP53 in Biology and Treatment of Osteosarcoma

Synoradzki, K. J., Bartnik, E., Czarnecka, A. M., Fiedorowicz, M., Firlej, W., Brodziak, A., Stasinska, A., Rutkowski, P. L., & Grieb, P. (2021) · Cancers · doi:10.3390/cancers13174284 · Cited by 66

Genome-wide analysis of alternative promoters of human genes using a custom promoter tiling array

Singer, G. A. C., Wu, J., Yan, P. S., Plass, C., Huang, T. H. ‐., & Davuluri, R. V. (2008) · BMC Genomics · doi:10.1186/1471-2164-9-349 · Cited by 62

Breast cancer prognostication and prediction in the postgenomic era

Lønning, P. E., Knappskog, S., Staalesen, V., Chrisanthar, R., & Lillehaug, J. (2007) · Annals of Oncology · doi:10.1093/annonc/mdm013 · Cited by 63

Cancer‐specific mutations in p53 induce the translation of Δ160p53 promoting tumorigenesis

Candeias, M. M., Hagiwara, M., & Matsuda, M. (2016) · EMBO Reports · doi:10.15252/embr.201541956 · Cited by 64

p53 and TAp63 participate in the recombination-dependent pachytene arrest in mouse spermatocytes

Marcet-Ortega, M., Pacheco, S., Martínez-Marchal, A., Castillo‐Ecija, H., Flores, E. R., Jasin, M., Keeney, S., & Roig, I. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1006845 · Cited by 63

The role of DEAD‐box RNA helicase p68 (DDX5) in the development and treatment of breast cancer

Hashemi, V., Masjedi, A., Hazhirkarzar, B., Tanomand, A., Shotorbani, S. S., Hojjat‐Farsangi, M., Ghalamfarsa, G., Azizi, G., Anvari, E., Baradaran, B., et al. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26912 · Cited by 61

GD2‐directed CAR‐T cells in combination with HGF‐targeted neutralizing antibody (AMG102) prevent primary tumor growth and metastasis in Ewing sarcoma

Charan, M., Dravid, P., Cam, M., Audino, A., Gross, A. C., Arnold, M. A., Roberts, R. D., Cripe, T. P., Pertsemlidis, A., Houghton, P. J., et al. (2020) · International Journal of Cancer · doi:10.1002/ijc.32743 · Cited by 59

C-terminal diversity within the p53 family accounts for differences in DNA binding and transcriptional activity

Sauer, M., Bretz, A. C., Beinoravičiūtė-Kellner, R., Beitzinger, M., Burek, M., Rosenwald, A., Harms, G. S., & Stiewe, T. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn044 · Cited by 64

Comparative Genomics and Evolution of Alternative Splicing: The Pessimists' Science

Artamonova, I. I., & Gelfand, M. S. (2007) · Chemical Reviews · doi:10.1021/cr068304c · Cited by 57

Prognostic interaction between expression of p53 and estrogen receptor in patients with node-negative breast cancer: results from IBCSG Trials VIII and IX

Coates, A. S., Millar, E. K. A., O'Toole, S. A., Molloy, T. J., Viale, G., Goldhirsch, A., Regan, M. M., Gelber, R. D., Sun, Z., Castiglione‐Gertsch, M., et al. (2012) · Breast Cancer Research · doi:10.1186/bcr3348 · Cited by 62

Structural Evolution and Dynamics of the p53 ProteinsPreprint

Chillemi, G., Kehrloesser, S., Bernassola, F., Desideri, A., Dötsch, V., Levine, A. J., & Melino, G. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a028308 · Cited by 64

Structural diversity of p63 and p73 isoforms

Osterburg, C., & Dötsch, V. (2022) · Cell Death and Differentiation · doi:10.1038/s41418-022-00975-4 · Cited by 67

Alterations of p63 and p73 in Human Cancers

Inoue, K., & Fry, E. A. (2014) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-017-9211-0_2 · Cited by 63

Drosophila p53 isoforms differentially regulate apoptosis and apoptosis-induced proliferation

Dichtel-Danjoy, M.-L., Ma, D., Dourlen, P., Chatelain, G., Napoletano, F., Robin, M., Corbet, M., Levet, C., Hafsi, H., Hainaut, P. L., et al. (2012) · Cell Death and Differentiation · doi:10.1038/cdd.2012.100 · Cited by 65

MDM2 inhibitor Nutlin-3a suppresses proliferation and promotes apoptosis in osteosarcoma cells

Wang, B., Fang, L., Zhao, H., Xiang, T., & Wang, D. (2012) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gms053 · Cited by 58

p73 coordinates with Δ133p53 to promote DNA double-strand break repair

Gong, H., Zhang, Y., Jiang, K., Ye, S., Chen, S., Zhang, Q., Peng, J., & Chen, J. (2018) · Cell Death and Differentiation · doi:10.1038/s41418-018-0085-8 · Cited by 59

Differentiated embryo-chondrocyte expressed gene 1 regulates p53-dependent cell survival versus cell death through macrophage inhibitory cytokine-1

Qian, Y., Jung, Y.-S., & Chen, X. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1203185109 · Cited by 59

P53 transcriptional activities: A general overview and some thoughts

Millau, J., Bastien, N., & Drouin, R. (2008) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2008.06.002 · Cited by 65

Tied Up in Loops: Positive and Negative Autoregulation of p53Preprint

Lü, X. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a000984 · Cited by 58

p53 Isoforms in Cellular Senescence- and Ageing-Associated Biological and Physiological Functions

Fujita, K. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20236023 · Cited by 59

p53 isoforms gain functions

Olivares‐Illana, V., & Fåhræus, R. (2010) · Oncogene · doi:10.1038/onc.2010.266 · Cited by 58

A novel isoform of the 8p22 tumor suppressor gene DLC1 suppresses tumor growth and is frequently silenced in multiple common tumors

Low, J. S. W., Tao, Q., Ng, K. M., Goh, H. K., Shu, X.-S., Woo, W. L., Ambinder, R. F., Srivastava, G., Shamay, M., Chan, A. T. �., et al. (2011) · Oncogene · doi:10.1038/onc.2010.576 · Cited by 57

Mutant p53 oncogenicity: dominant-negative or gain-of-function?

Stein, Y., Aloni-Grinstein, R., & Rotter, V. (2020) · Carcinogenesis · doi:10.1093/carcin/bgaa117 · Cited by 62

AP endonuclease 1 (Apex1) influences brain development linking oxidative stress and DNA repair

Pei, D., Jia, P., Luo, J., Liu, W., & Strauss, P. R. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1578-1 · Cited by 57

p53 as an intervention target for cancer and aging

Hasty, P., & Christy, B. A. (2013) · Pathobiology of Aging & Age-related Diseases · doi:10.3402/pba.v3i0.22702 · Cited by 57

High-resolution functional annotation of human transcriptome: predicting isoform functions by a novel multiple instance-based label propagation method

Li, W., Kang, S., Liu, C.-C., Zhang, S., Shi, Y., Liu, Y., & Zhou, X. J. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt1362 · Cited by 56

p53 ubiquitination by Mdm2: A never ending tail?

Coutts, A. S., Adams, C., & Thangue, N. B. L. (2009) · DNA repair · doi:10.1016/j.dnarep.2009.01.008 · Cited by 56

Δ40 Isoform of p53 Controls β-Cell Proliferation and Glucose Homeostasis in Mice

Hinault, C., Kawamori, D., Liew, C. W., Maier, B., Hu, J., Keller, S. R., Mirmira, R. G., Scrable, H. J., & Kulkarni, R. (2011) · Diabetes · doi:10.2337/db09-1379 · Cited by 57

Innate Immune Response and Off-Target Mis-splicing Are Common Morpholino-Induced Side Effects in Xenopus

Gentsch, G. E., Spruce, T., Monteiro, R. S., Owens, N. D. L., Martin, S. R., & Smith, J. C. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.01.022 · Cited by 57

Cancer-Associated Perturbations in Alternative Pre-messenger RNA Splicing

Shkreta, L., Bell, B., Revil, T., Venables, J. P., Prinos, P., Elela, S. A., & Chabot, B. (2013) · Cancer treatment and research · doi:10.1007/978-3-642-31659-3_3 · Cited by 55

Prognostic factors and survival analysis in a sample of oral squamous cell carcinoma patients

Oliveira, L. R., Ribeiro‐Silva, A., Costa, J. P., Simões, A. L., Matteo, M. Á. S. D., & Zucoloto, S. (2008) · Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology · doi:10.1016/j.tripleo.2008.07.002 · Cited by 55

Diverse p63 and p73 isoforms regulate Δ133p53 expression through modulation of the internal TP53 promoter activity

Marcel, V., Petit, I., Murray-Zmijewski, F., de Rugy, T. G., Fernandes, K., Meuray, V., Diot, A., Lane, D. P., Aberdam, D., & Bourdon, J. (2011) · Cell Death and Differentiation · doi:10.1038/cdd.2011.152 · Cited by 55

P44, the ‘longevity‐assurance’ isoform of P53, regulates tau phosphorylation and is activated in an age‐dependent fashion

Pehar, M., Ko, M. H., Li, M., Scrable, H. J., & Puglielli, L. (2013) · Aging Cell · doi:10.1111/acel.12192 · Cited by 57

p53 and little brother p53/47: linking IRES activities with protein functions

Grover, R., Candeias, M. M., Fåhræus, R., & Das, S. (2009) · Oncogene · doi:10.1038/onc.2009.138 · Cited by 54

The p53 Family Protein p73 Provides New Insights into Cancer Chemosensitivity and Targeting

Lunghi, P., Costanzo, A., Mazzera, L., Rizzoli, V., Levrero, M., & Bonati, A. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-1229 · Cited by 54

p53 family in development

Danilova, N., Sakamoto, K. M., & Lin, S. (2008) · Mechanisms of Development · doi:10.1016/j.mod.2008.09.003 · Cited by 55

Usage of cancer associated autoantibodies in the detection of disease

Dudas, S. P., Chatterjee, M., & Tainsky, M. A. (2010) · Cancer Biomarkers · doi:10.3233/cbm-2009-0138 · Cited by 53

Redox Control and Interplay Between p53 Isoforms: Roles in the Regulation of Basal p53 Levels, Cell Fate, and Senescence

Hafsi, H., & Hainaut, P. L. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3771 · Cited by 60

Mapping genetic alterations causing chemoresistance in cancer: identifying the roads by tracking the drivers

Lønning, P. E., & Knappskog, S. (2013) · Oncogene · doi:10.1038/onc.2013.48 · Cited by 54

p53 isoform profiling in glioblastoma and injured brain

Takahashi, R., Giannini, C., Sarkaria, J. N., Schroeder, M., Rogers, J., Mastroeni, D., & Scrable, H. J. (2012) · Oncogene · doi:10.1038/onc.2012.322 · Cited by 52

Expression of novel p53 isoforms in oral lichen planus

Ebrahimi, M., Boldrup, L., Coates, P. J., Wahlin, Y., Bourdon, J., & Nylander, K. (2007) · Oral Oncology · doi:10.1016/j.oraloncology.2007.01.014 · Cited by 52

Sequence-dependent cooperative binding of p53 to DNA targets and its relationship to the structural properties of the DNA targets

Beno, I., Rosenthal, K., Levitine, M., Shaulov, L., & Haran, T. E. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq1044 · Cited by 51

Inhibitory Role of Plk1 in the Regulation of p73-dependent Apoptosis through Physical Interaction and Phosphorylation

Koida, N., Ozaki, T., Yamamoto, H., Ono, S., Koda, T., Ando, K., Okoshi, R., Kamijo, T., Omura, K., & Nakagawara, A. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m710608200 · Cited by 51

P68 RNA helicase as a molecular target for cancer therapy

Dai, T.-Y., Cao, L., Yang, Z., Li, Y., Tan, L., Ran, X., & Shi, C. (2014) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/preaccept-9737114991295403 · Cited by 50

Nucleolar and Ribosomal DNA Structure under Stress: Yeast Lessons for Aging and Cancer

Matos‐Perdomo, E., & Machín, F. (2019) · Cells · doi:10.3390/cells8080779 · Cited by 53

Δ133p53 is an independent prognostic marker in p53 mutant advanced serous ovarian cancer

Hofstetter, G., Berger, A., Schuster, E., Wolf, A. M., Hager, G., Vergote, I. B., Cadron, I., Sehouli, J., Braicu, E. I., Mahner, S., et al. (2011) · British Journal of Cancer · doi:10.1038/bjc.2011.433 · Cited by 50

Regulation of Fertility by the p53 Family Members

Hu, W., Zheng, T., & Wang, J. (2011) · Genes & Cancer · doi:10.1177/1947601911408892 · Cited by 50

The Role of the p53 Protein in Stem-Cell Biology and Epigenetic RegulationPreprint

Levine, A. J., Puzio‐Kuter, A. M., Chan, C. S., & Hainaut, P. L. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a026153 · Cited by 53

Drosophila p53 integrates the antagonism between autophagy and apoptosis in response to stress

Robin, M., Issa, A.-R., Santos, C. C., Napoletano, F., Petitgas, C., Chatelain, G., Ruby, M., Walter, L., Birman, S., Domingos, P. M., et al. (2018) · Autophagy · doi:10.1080/15548627.2018.1558001 · Cited by 49

Adaptive homeostasis and the p53 isoform network

Mehta, S. Y., Campbell, H. G., Drummond, C. J., Li, K., Murray, K., Slatter, T. L., Bourdon, J., & Braithwaite, A. W. (2021) · EMBO Reports · doi:10.15252/embr.202153085 · Cited by 50

Trichostatin A and sirtinol suppressed survivin expression through AMPK and p38MAPK in HT29 colon cancer cells

Hsu, Y.-F., Sheu, J., Lin, C., Yang, D.-S., Hsiao, G., Ou, G., Chiu, P.-T., Huang, Y., Kuo, W.-H., & Hsu, M. (2011) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2011.11.011 · Cited by 49

Small ubiquitin-related modifier paralogs are indispensable but functionally redundant during early development of zebrafish

Yuan, H., Zhou, J., Deng, M., Liu, X., Bras, M. L., de Thé, H., Chen, S., Chen, Z., Liu, T. X., & Zhu, J. (2009) · Cell Research · doi:10.1038/cr.2009.101 · Cited by 49

Targeting TopBP1 at a convergent point of multiple oncogenic pathways for cancer therapy

Chowdhury, P., Lin, G. E., Liu, K., Song, Y., Lin, F., & Lin, W.-C. (2014) · Nature Communications · doi:10.1038/ncomms6476 · Cited by 51

Post-translational regulation of p53 function through 20S proteasome-mediated cleavage

Solomon, H., Bräuning, B., Fainer, I., Ben‐Nissan, G., Rabani, S., Goldfinger, N., Moscovitz, O., Shakked, Z., Rotter, V., & Sharon, M. (2017) · Cell Death and Differentiation · doi:10.1038/cdd.2017.139 · Cited by 50

Simultaneous Detection of Human C‑Terminal p53 Isoforms by Single Template Molecularly Imprinted Polymers (MIPs) Coupled with Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)-Based Targeted Proteomics

Jiang, W., Liu, L., & Chen, Y. (2018) · Analytical Chemistry · doi:10.1021/acs.analchem.7b02890 · Cited by 49

The Rich World of p53 DNA Binding Targets: The Role of DNA Structure

Brázda, V., & Fojta, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20225605 · Cited by 56

Effect of p63 Expression on Survival in Oral Squamous Cell Carcinoma

Muzio, L. L., Campisi, G., Farina, A., Rubini, C., Pastore, L., Giannone, N., Colella, G., Leonardi, R. M., & Carinci, F. (2007) · Cancer Investigation · doi:10.1080/07357900701509387 · Cited by 49

Ratio disruption of the Δ133p53 and TAp53 isoform equilibrium correlates with poor clinical outcome in intrahepatic cholangiocarcinoma

NUTTHASIRIKUL, N., Limpaiboon, T., Leelayuwat, C., Patrakitkomjorn, S., & Jearanaikoon, P. (2013) · International Journal of Oncology · doi:10.3892/ijo.2013.1818 · Cited by 48

p53 Basic C Terminus Regulates p53 Functions through DNA Binding Modulation of Subset of Target Genes

Hamard, P.-J., Lukin, D. J., & Manfredi, J. J. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.331298 · Cited by 57

Caffeine induces tumor cytotoxicity via the regulation of alternative splicing in subsets of cancer-associated genes

Lu, G., Huang, S., Liu, S., Liu, P., Chou, W., & Lin, W. (2013) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2013.12.004 · Cited by 48

The interplay between Epstein-Bar virus (EBV) with the p53 and its homologs during EBV associated malignancies

Chatterjee, K., Das, P., Chattopadhyay, N. R., Mal, S., & Choudhuri, T. (2019) · Heliyon · doi:10.1016/j.heliyon.2019.e02624 · Cited by 48

The Δ133p53β isoform promotes an immunosuppressive environment leading to aggressive prostate cancer

Kazantseva, M., Mehta, S. Y., Eiholzer, R. A., Gimenez, G., Bowie, S., Campbell, H. G., Reily-Bell, A. L., Roth, I. M., Ray, S., Drummond, C. J., et al. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1861-1 · Cited by 47

Protein lysine acetylation in normal and leukaemic haematopoiesis: HDACs as possible therapeutic targets in adult AML

Bruserud, Ø., Stapnes, C., Tronstad, K. J., Ryningen, A., Ånensen, N., & Gjertsen, B. T. (2006) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.10.1.51 · Cited by 48

Signaling to the p53 Tumor Suppressor through Pathways Activated by Genotoxic and Non-Genotoxic Stresses

Anderson, C. W., & Appella, E. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374145-5.00264-3 · Cited by 49

TP53 Mutation in Acute Myeloid Leukemia: An Old Foe Revisited

Shin, D.-Y. (2023) · Cancers · doi:10.3390/cancers15194816 · Cited by 46

The N-Terminally Truncated p53 Isoform △40p53 Influences Prognosis in Mucinous Ovarian Cancer

Hofstetter, G., Berger, A., Berger, R., Zorić, A., Braicu, E. I., Reimer, D., Fiegl, H., Marth, C., Zeimet, A. G., Ulmer, H., et al. (2012) · International Journal of Gynecological Cancer · doi:10.1097/igc.0b013e31823ca031 · Cited by 46

The Fatty Acid Synthase Gene is a Conserved p53 Family Target Gene from Worm to Human

D’Erchia, A. M., Tullo, A., Lefkimmiatis, K., Saccone, C., & Sbisà, E. (2006) · Cell Cycle · doi:10.4161/cc.5.7.2622 · Cited by 48

Matrine-induced autophagy regulated by p53 through AMP-activated protein kinase in human hepatoma cells

XIE, S.-B., He, X., & Yao, S. (2015) · International Journal of Oncology · doi:10.3892/ijo.2015.3023 · Cited by 45

The curcumin analog HO-3867 selectively kills cancer cells by converting mutant p53 protein to transcriptionally active wildtype p53

Madan, E., Parker, T. M., Bauer, M. R., Dhiman, A., Pelham, C. J., Nagane, M., Kuppusamy, M. L., Holmes, M., Holmes, T. R., Shaik, K., et al. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra117.000950 · Cited by 45

The role of p73 in hematological malignancies

Pluta, A., Nyman, U., Joseph, B., Robak, T., Zhivotovsky, B., & Smolewski, P. (2006) · Leukemia · doi:10.1038/sj.leu.2404166 · Cited by 45

The jury is in: p73 is a tumor suppressor after all: Figure 1.Preprint

Rosenbluth, J. M., & Pietenpol, J. A. (2008) · Genes & Development · doi:10.1101/gad.1727408 · Cited by 45

Transcription Factors in the Cellular Response to Charged Particle Exposure

Hellweg, C. E., Spitta, L. F., Henschenmacher, B., Diegeler, S., & Baumstark‐Khan, C. (2016) · Frontiers in Oncology · doi:10.3389/fonc.2016.00061 · Cited by 46

p73: A chiaroscuro gene in cancer

Marabese, M., Vikhanskaya, F., & Broggini, M. (2007) · European Journal of Cancer · doi:10.1016/j.ejca.2007.01.042 · Cited by 43

The Nonstructural NS1 Protein of Influenza Viruses Modulates TP53 Splicing through Host Factor CPSF4

Dubois, J., Traversier, A., Julien, T., Padey, B., Lina, B., Bourdon, J., Marcel, V., Boivin, G., Rosa‐Calatrava, M., & Terrier, O. (2019) · Journal of Virology · doi:10.1128/jvi.02168-18 · Cited by 45

Conformational stability and dynamics of the cancer‐associated isoform Δ133p53β are modulated by p53 peptides and p53‐specific DNA

Lei, J., Qi, R., Tang, Y., Wang, W., Wei, G., Nussinov, R., & Ma, B. (2018) · The FASEB Journal · doi:10.1096/fj.201801973r · Cited by 45

Only Missense Mutations Affecting the DNA Binding Domain of P53 Influence Outcomes in Patients with Breast Carcinoma

Végran, F., Rebucci, M., Chevrier, S., Cadouot, M., Boidot, R., & Lizard‐Nacol, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055103 · Cited by 43

S100A2 gene is a direct transcriptional target of p53 homologues during keratinocyte differentiation

Lapi, E., Iovino, A. J., Fontemaggi, G., Soliera, A. R., Iacovelli, S., Sacchi, A., Rechavi, G., Givol, D., Blandino, G., & Strano, S. (2006) · Oncogene · doi:10.1038/sj.onc.1209401 · Cited by 42

The Role of p53 Tumor-Suppressor Protein in Apoptosis and Cancerogenesis

Maximov, G. K., & Maximov, K. G. (2008) · Biotechnology & Biotechnological Equipment · doi:10.1080/13102818.2008.10817532 · Cited by 46

Importance of p53 for cancer onset and therapy

Haupt, S., & Haupt, Y. (2006) · Anti-Cancer Drugs · doi:10.1097/01.cad.0000217422.52208.fa · Cited by 44

Canonical and non-canonical functions of p53 isoforms: potentiating the complexity of tumor development and therapy resistance

Guo, Y., Wu, H., Wiesmüller, L., & Chen, M. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06783-7 · Cited by 40

Elevation of the TP53 isoform Δ133p53β in glioblastomas: an alternative to mutant p53 in promoting tumor development

Kazantseva, M., Eiholzer, R. A., Mehta, S. Y., Taha, A. J., Bowie, S., Roth, I. M., Zhou, J., Joruiz, S. M., Royds, J. A., Hung, N. A., et al. (2018) · The Journal of Pathology · doi:10.1002/path.5111 · Cited by 46

SpliceCenter: A suite of web-based bioinformatic applications for evaluating the impact of alternative splicing on RT-PCR, RNAi, microarray, and peptide-based studies

Ryan, M., Zeebèrg, B. R., Caplen, N. J., Cleland, J., Kahn, A., Liu, H., & Weinstein, J. N. (2008) · BMC Bioinformatics · doi:10.1186/1471-2105-9-313 · Cited by 41

SP600125 has a remarkable anticancer potential against undifferentiated thyroid cancer through selective action on ROCK and p53 pathways

Grassi, E., Vezzoli, V., Negri, I., Lábadi, Á., Fugazzola, L., Vitale, G., & Persani, L. (2015) · Oncotarget · doi:10.18632/oncotarget.5799 · Cited by 40

Aberrant splicing of the DMP1 ‐ ARF ‐ MDM2 ‐p53 pathway in cancer

Inoue, K., & Fry, E. A. (2016) · International Journal of Cancer · doi:10.1002/ijc.30003 · Cited by 40

The Δ133p53 Isoforms, Tuners of the p53 Pathway

Joruiz, S. M., Beck, J. A., Horikawa, I., & Harris, C. C. (2020) · Cancers · doi:10.3390/cancers12113422 · Cited by 40

Genetic Disruption of the Sh3pxd2a Gene Reveals an Essential Role in Mouse Development and the Existence of a Novel Isoform of Tks5

Cejudo–Martín, P., Yuen, A., Vlahovich, N., Lock, P., Courtneidge, S. A., & Díaz, B. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107674 · Cited by 42

The Isoforms of the p53 Protein

Khoury, M. P., & Bourdon, J.-C. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a000927 · Cited by 191

p53 Isoforms as Modifiers of the p53-Dependent Responses: A Hidden Code?

Bartolomei, L., Pretto, B., Brugnara, S., Sontacchi, A., Dassi, V., Bousrih, A., Damaggio, C., Flangini, F., Bisio, A., & Ciribilli, Y. (2026) · Cancers · doi:10.3390/cancers18071057 · Cited by 3

P53 and cancer

Das, D. (2011)

p53: link to the past, bridge to the futurePreprint

Mills, A. A. (2005) · Genes & Development · doi:10.1101/gad.1362905 · Cited by 81

p53 Family Isoforms

Bourdon, J. (2007) · Current Pharmaceutical Biotechnology · doi:10.2174/138920107783018444 · Cited by 81