p53 isoforms can regulate p53 transcriptional activity

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P63 and P73 Activation in Cancers with p53 Mutation

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Enhancing chimeric antigen receptor T cell therapy by modulating the p53 signaling network with Δ133p53α

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Targeting the Δ133p53 isoform can restore chemosensitivity in 5-fluorouracil-resistant cholangiocarcinoma cells

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The novel platinum(IV) complex LA-12 induces p53 and p53/47 responses that differ from the related drug, cisplatin

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Identification of p53 and Its Isoforms in Human Breast Carcinoma Cells

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Identification of Breast Cancer Subtype Specific MicroRNAs Using Survival Analysis to Find Their Role in Transcriptomic Regulation

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The calcium binding protein ALG-2 binds and stabilizes Scotin, a p53-inducible gene product localized at the endoplasmic reticulum membrane

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The can and can’t dos of p53 RNA

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Expression of full-length p53 and its isoform Deltap53 in breast carcinomas in relation to mutation status and clinical parameters.

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The amyloid precursor protein (APP) intracellular domain regulates translation of p44, a short isoform of p53, through an IRES-dependent mechanism

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TAp73α Increases p53 Tumor Suppressor Activity in Thyroid Cancer Cells via the Inhibition of Mdm2-Mediated Degradation

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Detecting p53 Isoforms at Protein Level

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Porcine model elucidates function of p53 isoform in carcinogenesis and reveals novel circTP53 RNA

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Δ40p53 isoform up-regulates netrin-1/UNC5B expression and potentiates netrin-1 pro-oncogenic activity

Sun, Y., Manceau, A., Frydman, L., Cappuccio, L., Neves, D., Basso, V., Wang, H., Fombonne, J., Maisse, C., Mehlen, P., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2103319118 · Cited by 25

Constitutive and induced functions of the p53 gene

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Metabolic pathways regulated by TAp73 in response to oxidative stress

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The role of p53 isoforms’ expression and p53 mutation status in renal cell cancer prognosis

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A Comprehensive Test System to Identify Suitable Antibodies Against p53 for Immunohistochemical Analysis of Canine Tissues

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NF-κB regulates the stability and activity of p73 by inducing its proteolytic degradation through a ubiquitin-dependent proteasome pathway

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p73 Plays a Role in Erythroid Differentiation through GATA1 Induction

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Expression of p53 N-terminal isoforms in B-cell precursor acute lymphoblastic leukemia and its correlation with clinicopathological profiles

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p53/p73 Protein Network in Colorectal Cancer and Other Human Malignancies

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Recent Findings on Therapeutic Cancer Vaccines: An Updated Review

Sheikhlary, S., Lopez, D. H., Moghimi, S., & Sun, B. (2024) · Biomolecules · doi:10.3390/biom14040503 · Cited by 22

Selective regression of cancer cells expressing a splicing variant of AIMP2 through targeted RNA replacement by trans-splicing ribozyme

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Regulating the genome surveillance system: miRNAs and the p53 super family

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‘O-GlcNAc Code’ Mediated Biological Functions of Downstream Proteins

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What is the potential of p53 isoforms as a predictive biomarker in the treatment of cancer?

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Prevalence of germline mutations in the TP53 gene in patients with early-onset breast cancer in the Mexican population

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Comparison of Three Different Methods for Determining Cell Proliferation in Breast Cancer Cell Lines

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Detecting and Quantifying p53 Isoforms at mRNA Level in Cell Lines and Tissues

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The Naturally Occurring ∆40p53 Isoform Inhibits eRNA Transcription and Enables Context-Specific Regulation During p53 Activation

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Effect of p53 and its N‐terminally truncated isoform, Δ40p53, on breast cancer migration and invasion

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p53 Signaling on Microenvironment and Its Contribution to Tissue Chemoresistance

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Alterations in the p53 isoform ratio govern breast cancer cell fate in response to DNA damage

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p53 Family: Therapeutic Targets in Neuroblastoma

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The Significance of p53 Isoform Expression in Serous Ovarian Cancer

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A mouse model of the Δ133p53 isoform: roles in cancer progression and inflammation

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Functional interplay between p53 and Δ133p53 in adaptive stress response

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p53 isoform Δ113p53 promotes zebrafish heart regeneration by maintaining redox homeostasis

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E2 Ligase dRad6 Regulates DMP53 Turnover in Drosophila

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Expression of the melanoma-associated antigen is associated with progression of human thyroid cancer

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Patient-derived tumor organoids mimic treatment-induced DNA damage response in glioblastoma

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New small molecules, ISA27 and SM13, inhibit tumour growth inducing mitochondrial effects of p53

Sorriento, D., Giudice, C. D., Bertamino, A., Ciccarelli, M., Gomez-Monterrey, I. M., Campiglia, P., Novellino, E., Illario, M., Trimarco, B., LUCA, N. D., et al. (2014) · British Journal of Cancer · doi:10.1038/bjc.2014.577 · Cited by 20

Loss-of-function of p53 isoform Δ113p53 accelerates brain aging in zebrafish

Zhao, T., Ye, S., Tang, Z., Guo, L., Ma, Z., Zhang, Y., Yang, C., Peng, J., & Chen, J. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03438-9 · Cited by 20

Identification and characterization of the interferon‐β‐mediated p53 signal pathway in human peripheral blood mononuclear cells

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Golgi-SNARE GS28 potentiates cisplatin-induced apoptosis by forming GS28–MDM2–p53 complexes and by preventing the ubiquitination and degradation of p53

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c-Jun regulates the promoter of small subunit hemocyanin gene of Litopenaeus vannamei

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Acidosis‐induced activation of distal nephron principal cells triggers Gdf15 secretion and adaptive proliferation of intercalated cells

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p53 Protein Isoforms: Key Regulators in the Front Line of Pathogen Infections?

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A comprehensive study of TP53 mutations in chronic lymphocytic leukemia: Analysis of 1287 diagnostic and 1148 follow-up CLL samples

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p53 isoforms change p53 paradigm

Bourdon, J. (2014) · Molecular & Cellular Oncology · doi:10.4161/23723548.2014.969136 · Cited by 23

P53 protein overexpression in de novo acute myeloid leukemia patients with normal diploid karyotype correlates with FLT3 internal tandem duplication and worse relapse‐free survival

Assi, R. E., Gur, H. D., Loghavi, S., Konoplev, S. N., Konopleva, M. Y., Daver, N. G., Tashakori, M., Kadia, T. M., Routbort, M. J., Salem, A., et al. (2018) · American Journal of Hematology · doi:10.1002/ajh.25255 · Cited by 19

p53 Frameshift Mutations Couple Loss-of-Function with Unique Neomorphic Activities

Tong, D. R., Zhou, W., Katz, C., Regunath, K., Venkatesh, D., Ihuegbu, C., Manfredi, J. J., Laptenko, O., & Prives, C. L. (2021) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-20-0691 · Cited by 20

Evolution of Conformational Disorder & Diversity of the P53 Interactome

Huart, A.-S., & Hupp, T. R. (2013) · Biodiscovery · doi:10.7750/biodiscovery.2013.8.5 · Cited by 18

Asymmetric Cell Division and Template DNA Co-Segregation in Cancer Stem Cells

Pine, S. R., & Liu, W. (2014) · Frontiers in Oncology · doi:10.3389/fonc.2014.00226 · Cited by 20

Mandarin fish p53: Genomic structure, alternatively spliced variant and its mRNA expression after virus challenge

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DNA-Damage-Induced Alternative Splicing of p53

Chen, J., Zhang, D., Qin, X., Owzar, K., McCann, J. J., & Kastan, M. B. (2021) · Cancers · doi:10.3390/cancers13020251 · Cited by 18

The p53 Family Members p63 and p73 Roles in the Metastatic Dissemination: Interactions with microRNAs and TGFβ Pathway

Calleja, L. R., Lavaud, M., Tesfaye, R. A., Royer, B. B.-L., Baud’huin, M., Georges, S., Lamoureux, F., Verrecchia, F., & Ory, B. (2022) · Cancers · doi:10.3390/cancers14235948 · Cited by 18

The p53 Isoform Δp53 Lacks Intrinsic Transcriptional Activity and Reveals the Critical Role of Nuclear Import in Dominant-Negative Activity

Chan, W. M., & Poon, R. Y. C. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3602 · Cited by 19

A functional interplay between Δ133p53 and ΔNp63 in promoting glycolytic metabolism to fuel cancer cell proliferation

Gong, L., Pan, X., Lim, C.-B., de Polo, A., Little, J. B., & Yuan, Z.-M. (2018) · Oncogene · doi:10.1038/s41388-017-0117-8 · Cited by 18

EASI—enrichment of alternatively spliced isoforms

Venables, J. P., & Burn, J. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl592 · Cited by 18

Study of p53 gene mutations and placental expression in recurrent miscarriage cases

Kaare, M., Bützow, R. C., Ulander, V., Kaaja, R., Aittomäki, K., & Painter, J. N. (2009) · Reproductive BioMedicine Online · doi:10.1016/s1472-6483(10)60105-8 · Cited by 18

P53-Related Anticancer Activities of Drimia calcarata Bulb Extracts Against Lung Cancer

Laka, K., & Mbita, Z. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.876213 · Cited by 17

TheTP53Gene Network in a Postgenomic Era

Soussi, T. (2014) · Human Mutation · doi:10.1002/humu.22562 · Cited by 17

p53-independent mechanisms regulate the P2-MDM2 promoter in adult astrocytic tumours

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The role of the 5' terminal region of p53 mRNA in the p53 gene expression

Świątkowska, A., Żydowicz-Machtel, P., Sroka, J., & Ciesiołka, J. (2016) · Acta Biochimica Polonica · doi:10.18388/abp.2016_1342 · Cited by 17

p53β: a new prognostic marker for patients with clear-cell renal cell carcinoma from 5.3 years of median follow-up

Zhang, H., Zhao, Y., Sun, P., Zhao, M., Su, Z., Jin, X., & Song, W. (2018) · Carcinogenesis · doi:10.1093/carcin/bgy001 · Cited by 17

The Undervalued Avenue to Reinstate Tumor Suppressor Functionality of the p53 Protein Family for Improved Cancer Therapy-Drug Repurposing

Zawacka‐Pankau, J. (2020) · Cancers · doi:10.3390/cancers12092717 · Cited by 16

An introduction to genes, genomes and disease

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The genetic depletion or the triptolide inhibition of TFIIH in p53 deficient cells induce a JNK-dependent cell death in Drosophila

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Inhibition of p53 expression by peptide-conjugated phosphorodiamidate morpholino oligomers sensitizes human cancer cells to chemotherapeutic drugs

Ma, W., Lin, Y., Xuan, W., Iversen, P. L., Smith, L. J., & Benchimol, S. (2011) · Oncogene · doi:10.1038/onc.2011.300 · Cited by 17

Differential effects of diverse p53 isoforms on TAp73 transcriptional activity and apoptosis

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Splicing Modulation Results in Aberrant Isoforms and Protein Products of p53 Pathway Genes and the Sensitization of B Cells to Non-Genotoxic MDM2 Inhibition

Aptullahoğlu, E., Ciardullo, C., Wallis, J. P., Marr, H. J., Marshall, S. R., Bown, N. P., Willmore, E., & Lunec, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032410 · Cited by 15

The Role of Structural Elements of the 5'-Terminal Region of p53 mRNA in Translation under Stress Conditions Assayed by the Antisense Oligonucleotide Approach

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Role of p53β in the inhibition of proliferation of gastric cancer cells expressing wild-type or mutated p53

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Δ133p53α enhances metabolic and cellular fitness of TCR-engineered T cells and promotes superior antitumor immunity

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