PreprintCited by 3,183Wnt/β-catenin signaling in development and cancerSignaling Pathways in DiseaseHedgehog Signaling Pathway Studies

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Wnt signaling and cancer

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Polakis, Paul·2000·Genes & Development

DOI 10.1101/gad.14.15.1837

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Abstract

The regulation of cell growth and survival can be subverted by a variety of genetic defects that alter transcriptional programs normally responsible for controlling cell number. High throughput analysis of these gene expression patterns should ultimately lead to the identification of minimal expression profiles that will serve as common denominators in assigning a cancer to a given category. In the course of defining the common denominators, though, we should not be too surprised to find that cancers within a single category may nevertheless exhibit seemingly disparate genetic defects. The wnt pathway has already provided an outstanding example of this. We now know of three regulatory genes in this pathway that are mutated in primary human cancers and several others that promote experimental cancers in rodents (Fig. 1). In all of these cases the common denominator is the activation of gene transcription by -catenin. The resulting gene expression profile should provide us with a signature common to those cancers carrying defects in the wnt pathway. In this review, the wnt pathway will be covered from the perspective of cancer, with emphasis placed on molecular defects known to promote neoplastic transformation in humans and in animal models.

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Identification of c- MYC as a Target of the APC Pathway
He, T.-C., Sparks, A. B., Rago, C., Hermeking, H., Zawel, L., da Costa, L. T., Morin, P. J., Vogelstein, B., & Kinzler, K. W. (1998) · Science · doi:10.1126/science.281.5382.1509 · Cited by 4,566
Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC
Morin, P. J., Sparks, A. B., Kořínek, V., Barker, N., Clevers, H. C., Vogelstein, B., & Kinzler, K. W. (1997) · Science · doi:10.1126/science.275.5307.1787 · Cited by 4,000
β-Catenin regulates expression of cyclin D1 in colon carcinoma cells
Tetsu, O., & McCormick, F. (1999) · Nature · doi:10.1038/18884 · Cited by 3,601
Functional interaction of β-catenin with the transcription factor LEF-1
Behrens, J., von Kries, J. P., Kühl, M., Bruhn, L., Wedlich, D., Grosschedl, R., & Birchmeier, W. (1996) · Nature · doi:10.1038/382638a0 · Cited by 2,912
Identification and characterization of the familial adenomatous polyposis coli gene
Groden, J. L., Thliveris, A. T., Samowitz, W. S., Carlson, M. L., Gelbert, L. M., Albertsen, H., Joslyn, G., Stevens, J., Spirio, L. N., Robertson, M. A., et al. (1991) · Cell · doi:10.1016/0092-8674(81)90021-0 · Cited by 2,794
Identification of FAP Locus Genes from Chromosome 5q21
Kinzler, K. W., Nilbert, M. C., Su, L.-K., Vogelstein, B., Bryan, T. M., Levy, D. B., Smith, K. J., Preisinger, A. C., Hedge, P., McKechnie, D., et al. (1991) · Science · doi:10.1126/science.1651562 · Cited by 2,331
The cyclin D1 gene is a target of the β-catenin/LEF-1 pathway
Shtutman, M., Zhurinsky, J., Simcha, I., Albanese, C., D’Amico, M., Pestell, R., & Ben-Ze’ev, A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.10.5522 · Cited by 2,230
MECHANISMS OF WNT SIGNALING IN DEVELOPMENT
Wodarz, A., & Nusse, R. (1998) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.14.1.59 · Cited by 2,030
Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome
Nusse, R., & VARMUS, H. E. (1982) · Cell · doi:10.1016/0092-8674(82)90409-3 · Cited by 1,864
XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos
Molenaar, M., van de Wetering, M., Oosterwegel, M., Peterson-Maduro, J., Godsave, S., Korinek, V., Roose, J., Destrée, O., & Clevers, H. (1996) · Cell · doi:10.1016/s0092-8674(00)80112-9 · Cited by 1,824

Show all 190 references

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Rubin, E. M., Guo, Y., Tu, K., Xie, J., Zi, X., & Hoang, B. H. (2010) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-09-0147 · Cited by 132
Association of Csk to VE‐cadherin and inhibition of cell proliferation
Baumeister, U., Funke, R., Ebnet, K., Vorschmitt, H., Koch, S., & Vestweber, D. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600647 · Cited by 132
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Yu, W., Renard, C.-A., Labalette, C., Wu, Y., Lévy, L., Neuveut, C., Prieur, X., Flajolet, M., Prigent, S., & Buendia, M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207216200 · Cited by 132
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Fujimuro, M., & Hayward, S. D. (2003) · Journal of Virology · doi:10.1128/jvi.77.14.8019-8030.2003 · Cited by 131
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Luo, W., Peterson, A. G., Garcia, B. A., Coombs, G. S., Kofahl, B., Heinrich, R., Shabanowitz, J., Hunt, D. F., Yost, H. J., & Virshup, D. M. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601607 · Cited by 132
Wnt1 and Wnt5a induce cyclin D1 expression through ErbB1 transactivation in HC11 mammary epithelial cells
Civenni, G., Holbro, T., & Hynes, N. E. (2003) · EMBO Reports · doi:10.1038/sj.embor.embor735 · Cited by 132
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Harwood, A. J., & Agam, G. (2003) · Biochemical Pharmacology · doi:10.1016/s0006-2952(03)00187-4 · Cited by 134
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Bierie, B., Nozawa, M., Renou, J., Shillingford, J. M., Morgan, F., Oka, T., Taketo, M. M., Cardiff, R. D., Miyoshi, K., Wagner, K., et al. (2003) · Oncogene · doi:10.1038/sj.onc.1206426 · Cited by 132
The CRM1 nuclear export protein in normal development and disease.
Nguyen, K. T., Holloway, M. P., & Altura, R. A. (2012) · Europe PMC (PubMed Central) · Cited by 131
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Armengol, C., Cairo, S., Fabrè, M., & Buendia, M. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2009.07.012 · Cited by 137
Regulation of leukemic cell adhesion, proliferation, and survival by β-catenin
Chung, E. J., Hwang, S., Nguyen, P., Lee, S., Kim, J.-S., Kim, J. W., Henkart, P. A., Bottaro, D. P., Soon, L., Bonvini, P., et al. (2002) · Blood · doi:10.1182/blood.v100.3.982 · Cited by 131
Identification of a global gene expression signature of B-chronic lymphocytic leukemia.
Jelinek, D. F., Tschumper, R. C., Stolovitzky, G. A., Iturria, S. J., Tu, Y., Lepre, J., Shah, N. H., & Kay, N. E. (2003) · PubMed · Cited by 131
Comparative developmental biology of the uterus: Insights into mechanisms and developmental disruption
Spencer, T. E., Dunlap, K. A., & Filant, J. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.09.035 · Cited by 139
“…that are homologous to the Drosophila segment polarity gene wingless (wg) and regulate stem cell fate, cell differentiation and tissue growth (Polakis, 2000) through frizzled receptors (Fzd) (Pandur et al., 2002) via canonical and noncanonical signaling pathways (Angers and Moon, 2009).”
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Wnt/β-Catenin activation promotes prostate tumor progression in a mouse model
Yu, X., Wang, Y., DeGraff, D. J., Wills, M. L., & Matusik, R. J. (2010) · Oncogene · doi:10.1038/onc.2010.560 · Cited by 130
Targeted inactivation of CTNNB1 reveals unexpected effects of β-catenin mutation
Chan, T. A.-T., Wang, Z., Dang, L. H., Vogelstein, B., & Kinzler, K. W. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.082240999 · Cited by 130
β-Catenin and E-Cadherin Expression Patterns in High-Grade Endometrial Carcinoma Are Associated with Histological Subtype
Schlosshauer, P. W., Ellenson, L. H., & Soslow, R. A. (2002) · Modern Pathology · doi:10.1097/01.mp.0000028573.34289.04 · Cited by 130
Identifying MicroRNA-mRNA regulatory network in colorectal cancer by a combination of expression profile and bioinformatics analysis
Fu, J., Tang, W., Du, P., Wang, G., Chen, W., Li, J., Zhu, Y., Gao, J., & Cui, L. (2012) · BMC Systems Biology · doi:10.1186/1752-0509-6-68 · Cited by 133
“In this study, only the Wnt signaling pathway, which had been proved to be aberrantly activated in CRC [45,46], was found to be affected”
Chromosome 8q24-Associated Cancers and MYC
Grisanzio, C., & Freedman, M. L. (2010) · Genes & Cancer · doi:10.1177/1947601910381380 · Cited by 130
Ginsenoside-Rg1 Induces Vascular Endothelial Growth Factor Expression through the Glucocorticoid Receptor-related Phosphatidylinositol 3-Kinase/Akt and β-Catenin/T-cell Factor-dependent Pathway in Human Endothelial Cells
Leung, K. W., Pon, Y. L., Wong, R. N., & Wong, A. S. T. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606698200 · Cited by 129
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Diseases of Wnt signaling
Johnson, M. L., & Rajamannan, N. M. (2006) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-006-9003-3 · Cited by 134
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Leow, C. C., Romero, M. S., Ross, S., Polakis, P. G., & Gao, W. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0290 · Cited by 129
Crosstalk between NF-κB and β-catenin pathways in bacterial-colonized intestinal epithelial cells
Sun, J., Hobert, M. E., Duan, Y., Rao, A. S., He, T., Chang, E. B., & Madara, J. (2005) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00515.2004 · Cited by 129
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Magrangeas, F., Nasser, V., Avet‐Loiseau, H., Loriod, B., Decaux, O., Granjeaud, S., Bertucci, F., Birnbaum, D., Nguyen, C., Harousseau, J., et al. (2003) · Blood · doi:10.1182/blood-2002-11-3385 · Cited by 129
High-Frequency Canonical Wnt Activation in Multiple Sarcoma Subtypes Drives Proliferation through a TCF/β-Catenin Target Gene, CDC25A
Vijayakumar, S., Liu, G., Rus, I. A., Yao, S., Chen, Y., Akiri, G., Grumolato, L., & Aaronson, S. A. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.03.010 · Cited by 128
MYBL2 is a substrate of GSK3-like kinase BIN2 and acts as a corepressor of BES1 in brassinosteroid signaling pathway in Arabidopsis
Ye, H., Li, L., Guo, H., & Yin, Y. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1205232109 · Cited by 128
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Fritzmann, J., Morkel, M., Besser, D., Budczies, J., Kosel, F., Brembeck, F. H., Stein, U., Fichtner, I., Schlag, P. M., & Birchmeier, W. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.03.041 · Cited by 128
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Thudi, N. K., Martin, C. K., Murahari, S., Shu, S. T., Lanigan, L. G., Werbeck, J. L., Keller, E. T., McCauley, L. K., Pinzone, J. J., & Rosol, T. J. (2010) · The Prostate · doi:10.1002/pros.21277 · Cited by 126
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Hahn, J., Cho, H.-J., Bae, J.-W., Yuk, H.-S., Kim, K., Park, K. W., Koo, B.-K., Chae, I., Shin, C.-S., Oh, B., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603916200 · Cited by 124
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Gao, Z., Xu, Z., Hung, M., Lin, Y., Wang, T., Gong, M., Zhi, X., Jablon, D. M., & You, L. (2009) · PubMed · Cited by 123
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Thorstensen, L., Lind, G. E., Løvig, T., Diep, C. B., Meling, G. I., Rognum, T. O., & Lothe, R. A. (2005) · Neoplasia · doi:10.1593/neo.04448 · Cited by 122
Novel genes regulated by Sonic Hedgehog in pluripotent mesenchymal cells
Ingram, W. J., Wicking, C., Grimmond, S. M., Forrest, A. R. R., & Wainwright, B. J. (2002) · Oncogene · doi:10.1038/sj.onc.1205975 · Cited by 122
Connective Tissue Growth Factor Is Overexpressed in Esophageal Squamous Cell Carcinoma and Promotes Tumorigenicity through β-Catenin-T-cell Factor/Lef Signaling
Deng, Y.-Z., Chen, P.-P., Wang, Y., Yin, D., Koeffler, H. P., Li, B., Tong, X.-J., & Xie, D. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704141200 · Cited by 122
Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chainsPreprint
Tran, H., Hamada, F., Schwarz, T., & Bienz, M. (2008) · Genes & Development · doi:10.1101/gad.463208 · Cited by 122
Inhibition of Fibroblast Growth Factor 19 Reduces Tumor Growth by Modulating β-Catenin Signaling
Pai, R., Dunlap, D. Y., Qing, J., Mohtashemi, I., Hötzel, K., & French, D. M. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-2325 · Cited by 124
APC dosage effects in tumorigenesis and stem cell differentiation
Gaspar, C., & Fodde, R. (2004) · The International Journal of Developmental Biology · doi:10.1387/ijdb.041807cg · Cited by 123
Inactivation of theAPCGene Is Constant in Adrenocortical Tumors from Patients with Familial Adenomatous Polyposis but Not Frequent in Sporadic Adrenocortical Cancers
Gaujoux, S., Pinson, S., Gimenez‐Roqueplo, A., Amar, L., Ragazzon, B., Launay, P., Méatchi, T., Libé, R., BERTAGNA, X. Y., Audebourg, A., et al. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-1497 · Cited by 121
The Crystal Structure of the β-Catenin/ICAT Complex Reveals the Inhibitory Mechanism of ICAT
Graham, T. A., Clements, W. K., Kimelman, D., & Xu, W. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00637-8 · Cited by 124
Deletion of a Single β-Catenin Allele in Osteocytes Abolishes the Bone Anabolic Response to Loading
Javaheri, B., Stern, A. R., Lara, N., Dallas, M., Zhao, H. L., Liu, Y., Bonewald, L. F., & Johnson, M. L. (2013) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2064 · Cited by 124
Frequent epigenetic inactivation of SFRP genes in hepatocellular carcinoma
Takagi, H., Sasaki, S., Suzuki, H., Toyota, M., Maruyama, R., Nojima, M., Yamamoto, H., Omata, M., Tokino, T., Imai, K., et al. (2008) · Journal of Gastroenterology · doi:10.1007/s00535-008-2170-0 · Cited by 119
Unfolding the Role of Large Heat Shock Proteins: New Insights and Therapeutic Implications
Zuo, D., Subjeck, J. R., & Wang, X. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00075 · Cited by 122
“Given that the majority of colon cancer patients have APC mutations and active Wnt/β-catenin signaling, these findings establish Hsp110 as a prognostic biomarker and as a potential therapeutic target for the treatment of colon cancer (100, 101).”
Background
Wnt Signaling Inhibits Forkhead Box O3a-induced Transcription and Apoptosis through Up-regulation of Serum- and Glucocorticoid-inducible Kinase 1
Dehner, M., Hadjihannas, M. V., Weiske, J., Huber, O., & Behrens, J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m710366200 · Cited by 116
Caffeic acid phenethyl ester induces growth arrest and apoptosis of colon cancer cells via the β-catenin/T-cell factor signaling
Xiang, D., Wang, D., He, Y., Xie, J., Zhong, Z., Li, Z., & Xie, J. (2006) · Anti-Cancer Drugs · doi:10.1097/01.cad.0000224441.01082.bb · Cited by 119
Mouse models for colorectal cancer
Heyer, J., Yang, K., Lipkin, M., Edelmann, W., & Kucherlapati, R. (1999) · Oncogene · doi:10.1038/sj.onc.1203036 · Cited by 120
Expression of the gut-enriched Krüppel-like factor (Krüppel-like factor 4) gene in the human colon cancer cell line RKO is dependent on CDX2
Dang, D. T., Mahatan, C. S., Dang, L. H., Agboola, I. A., & Yang, V. W. (2001) · Oncogene · doi:10.1038/sj.onc.1204645 · Cited by 120
Lack of Adenomatous Polyposis Coli Protein Correlates with a Decrease in Cell Migration and Overall Changes in Microtubule Stability
Kroboth, K., Newton, I. P., Kita, K., Dikovskaya, D., Zumbrunn, J., Waterman, C. M., & Näthke, I. S. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-03-0179 · Cited by 119
Regulation of the G1 to S transition by the ubiquitin pathway
DeSalle, L. M., & Pagano, M. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02121-4 · Cited by 119
Vitamin D2 Analog 19-nor-1,25-Dihydroxyvitamin D2: Antitumor Activity Against Leukemia, Myeloma, and Colon Cancer Cells
Kumagai, T., O’Kelly, J., SAID, J. W., & Koeffler, H. P. (2003) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/95.12.896 · Cited by 121
Activation of Wnt signaling bypasses the requirement for RTK/Ras signaling during C. elegans vulval inductionPreprint
Gleason, J. E., Korswagen, H. C., & Eisenmann, D. M. (2002) · Genes & Development · doi:10.1101/gad.981602 · Cited by 119
Identification of the leukocyte cell-derived chemotaxin 2 as a direct target gene of β-catenin in the liver
Ovejero, C., Cavard, C., Périanin, A., Hakvoort, T., Vermeulen, J., Godard, C., Fabre, M., Chafey, P., Suzuki, K., Romagnolo, B., et al. (2004) · Hepatology · doi:10.1002/hep.20286 · Cited by 118
CYP1B1 Enhances Cell Proliferation and Metastasis through Induction of EMT and Activation of Wnt/β-Catenin Signaling via Sp1 Upregulation
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“Following activation by Wnt ligand-receptor binding, β-catenin escapes proteosomal degradation and translocates into the nucleus, where it binds its target genes and promotes multiple pathways involved in carcinogenesis [20, 21].”
BackgroundInfluential
ARIA, an Arabidopsis Arm Repeat Protein Interacting with a Transcriptional Regulator of Abscisic Acid-Responsive Gene Expression, Is a Novel Abscisic Acid Signaling Component
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Chan, A. O. O. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i2.199 · Cited by 118
Binding of APC and dishevelled mediates Wnt5a‐regulated focal adhesion dynamics in migrating cells
Matsumoto, S., Fumoto, K., Okamoto, T., Kaibuchi, K., & Kikuchi, A. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.26 · Cited by 120
miR-92b controls glioma proliferation and invasion through regulating Wnt/beta-catenin signaling via Nemo-like kinase
Wang, K., Wang, X., Zou, J., Zhang, A., Wan, Y., Pu, P., Song, Z., Qian, C., Chen, Y., Yang, S., et al. (2013) · Neuro-Oncology · doi:10.1093/neuonc/not004 · Cited by 117
“The Wnt signaling pathway regulates many biological processes through a complex of beta-catenin and the T cell factor/lymphoid-enhancer factor 1 (TCF/LEF-1) family of high-mobility group transcription factors.(3,4) Wnt stabilizes cytosolic betacatenin, which then binds to TCF/LEF-1 and recruits transcription factors B…”
Background
Vitamin D and Colon Carcinogenesis
Harris, D. M., & Go, V. L. W. (2004) · Journal of Nutrition · doi:10.1093/jn/134.12.3463s · Cited by 116
Antitumorigenic Effect of Wnt 7a and Fzd 9 in Non-small Cell Lung Cancer Cells Is Mediated through ERK-5-dependent Activation of Peroxisome Proliferator-activated Receptor γ
Winn, R. A., Scoyk, M. M. V., Hammond, M., Rodriguez, K. J., Crossno, J. T., Heasley, L. E., & Nemenoff, R. A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604145200 · Cited by 115
Adenomatous Polyposis Coli on Microtubule Plus Ends in Cell Extensions Can Promote Microtubule Net Growth with or without EB1
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Revisiting the role of Wnt/β-catenin signaling in prostate cancer
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“Introduction β-catenin is an effector of the Wnt family of proteins, an evolutionarily conserved group of signaling molecules that regulate developmental and biological processes (Miller et al., 1999; Polakis, 2000; Wodarz and Nusse, 1998).”
Background
The β-catenin/TCF complex as a novel target of resveratrol in the Wnt/β-catenin signaling pathway
Chen, H., Hsu, L.-S., Shia, Y.-T., Lin, M., & Lin, C.-M. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.08.011 · Cited by 120
Identification of a Role for β-Catenin in the Establishment of a Bipolar Mitotic Spindle
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TIP49 regulates beta-catenin-mediated neoplastic transformation and T-cell factor target gene induction via effects on chromatin remodeling.
Feng, Y., Lee, N., & Fearon, E. R. (2003) · PubMed · Cited by 116
Wnt signalling and cancer stem cells
Espada, J., Blanco, M., Díaz‐Prado, S., & Médina, V. (2009) · Clinical & Translational Oncology · doi:10.1007/s12094-009-0380-4 · Cited by 116

Authors: Polakis, P.
Affiliations: Genentech (US)
Corresponding author: Polakis, Paul
Venue: Genes & Development
Publisher: Cold Spring Harbor Laboratory
Published: 2000-08-01
Volume: 14
Issue: 15
Pages: 1837-1851
ISSN: 0890-9369 (ISSN-L)
1549-5477
DOI: 10.1101/gad.14.15.1837
OpenAlex: W2239090104
Cited by: 3,183
References: 190
Citations by year: 2026: 6 · 2025: 12 · 2024: 25 · 2023: 43 · 2022: 39 · 2021: 46 · 2020: 56 · 2019: 67 · 2018: 71 · 2017: 86 · 2016: 110 · 2015: 144 · 2014: 138 · 2013: 147 · 2012: 174
Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Genes & Development (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
Keywords: Wnt signaling, β-catenin, cancer, oncogenic transformation, transcriptional activation, gene expression profiles, experimental tumor model
MeSH terms: Dishevelled Proteins, Animals, Cytoskeletal Proteins, Humans, Neoplasms, Phosphoprotein Phosphatases, Phosphoproteins, Proto-Oncogene Proteins, Transcription Factors, Signal Transduction, Trans-Activators, Calcium-Calmodulin-Dependent Protein Kinases, Adenomatous Polyposis Coli Protein, Zebrafish Proteins, Glycogen Synthase Kinase 3, Adaptor Proteins, Signal Transducing, Wnt Proteins, beta Catenin

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