Wnt signaling and cancer

Identification of c- MYC as a Target of the APC Pathway

He, T.-C., Sparks, A. B., Rago, C., Hermeking, H., Zawel, L., da Costa, L. T., Morin, P. J., Vogelstein, B., & Kinzler, K. W. (1998) · Science · doi:10.1126/science.281.5382.1509 · Cited by 4,566

Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

Morin, P. J., Sparks, A. B., Kořínek, V., Barker, N., Clevers, H. C., Vogelstein, B., & Kinzler, K. W. (1997) · Science · doi:10.1126/science.275.5307.1787 · Cited by 4,000

β-Catenin regulates expression of cyclin D1 in colon carcinoma cells

Tetsu, O., & McCormick, F. (1999) · Nature · doi:10.1038/18884 · Cited by 3,601

Functional interaction of β-catenin with the transcription factor LEF-1

Behrens, J., von Kries, J. P., Kühl, M., Bruhn, L., Wedlich, D., Grosschedl, R., & Birchmeier, W. (1996) · Nature · doi:10.1038/382638a0 · Cited by 2,912

Identification and characterization of the familial adenomatous polyposis coli gene

Groden, J. L., Thliveris, A. T., Samowitz, W. S., Carlson, M. L., Gelbert, L. M., Albertsen, H., Joslyn, G., Stevens, J., Spirio, L. N., Robertson, M. A., et al. (1991) · Cell · doi:10.1016/0092-8674(81)90021-0 · Cited by 2,794

Identification of FAP Locus Genes from Chromosome 5q21

Kinzler, K. W., Nilbert, M. C., Su, L.-K., Vogelstein, B., Bryan, T. M., Levy, D. B., Smith, K. J., Preisinger, A. C., Hedge, P., McKechnie, D., et al. (1991) · Science · doi:10.1126/science.1651562 · Cited by 2,331

The cyclin D1 gene is a target of the β-catenin/LEF-1 pathway

Shtutman, M., Zhurinsky, J., Simcha, I., Albanese, C., D’Amico, M., Pestell, R., & Ben-Ze’ev, A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.10.5522 · Cited by 2,230

MECHANISMS OF WNT SIGNALING IN DEVELOPMENT

Wodarz, A., & Nusse, R. (1998) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.14.1.59 · Cited by 2,030

Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome

Nusse, R., & VARMUS, H. E. (1982) · Cell · doi:10.1016/0092-8674(82)90409-3 · Cited by 1,864

XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos

Molenaar, M., van de Wetering, M., Oosterwegel, M., Peterson-Maduro, J., Godsave, S., Korinek, V., Roose, J., Destrée, O., & Clevers, H. (1996) · Cell · doi:10.1016/s0092-8674(00)80112-9 · Cited by 1,824

Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4

Kořínek, V., Barker, N., Moerer, P., van Donselaar, E. V., Huls, G., Peters, P., & Clevers, H. (1998) · Nature Genetics · doi:10.1038/1270 · Cited by 1,704

Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction

Glinka, A., Wu, W., Delius, H., Monaghan, A. P., Blumenstock, C., & Niehrs, C. (1998) · Nature · doi:10.1038/34848 · Cited by 1,608

Multiple Intestinal Neoplasia Caused by a Mutation in the Murine Homolog of the APC Gene

Su, L.-K., Kinzler, K. W., Vogelstein, B., Preisinger, A. C., Moser, A. R., Luongo, C., Gould, K. A., & Dove, W. F. (1992) · Science · doi:10.1126/science.1350108 · Cited by 1,537

A new member of the frizzled family from Drosophila functions as a Wingless receptor

Bhanot, P., van den Brink, M. R. M., Samos, C. H., Hsieh, J.-C., Wang, Y., Macke, J. P., Andrew, D. J., Nathans, J., & Nusse, R. (1996) · Nature · doi:10.1038/382225a0 · Cited by 1,504

Binding of GSK3β to the APC-β-Catenin Complex and Regulation of Complex Assembly

Rubinfeld, B., Albert, I., Porfiri, E., Fiol, C. J., Munemitsu, S. M., & Polakis, P. G. (1996) · Science · doi:10.1126/science.272.5264.1023 · Cited by 1,420

Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF.

Wetering, M. L. V. D., Cavallo, R. A., Dooijes, D., van Beest, M., van Es, J. V., Loureiro, J., Ypma, A., Hursh, D., Jones, T. L., Bejsovec, A., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)81925-x · Cited by 1,347

Identification of a Member of the MAPKKK Family as a Potential Mediator of TGF-β Signal Transduction

Yamaguchi, T., Shirakabe, K., Shibuyà, H., Irie, K., Oishi, I., Ueno, N., Taniguchi, T., Nishida, E., & Matsumoto, K. (1995) · Science · doi:10.1126/science.270.5244.2008 · Cited by 1,344

Functional Interaction of an Axin Homolog, Conductin, with β-Catenin, APC, and GSK3β

Behrens, J., Jerchow, B., Würtele, M., Grimm, J., Asbrand, C., Wirtz, R. M., Kühl, M., Wedlich, D., & Birchmeier, W. (1998) · Science · doi:10.1126/science.280.5363.596 · Cited by 1,255

Wnt Signaling in Oncogenesis and Embryogenesis--a Look Outside the Nucleus

Peifer, M., & Polakis, P. (2000) · Science · doi:10.1126/science.287.5458.1606 · Cited by 1,253

Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK‐3β and β‐catenin and promotes GSK‐3β‐dependent phosphorylation of β‐catenin

Ikeda, S., Kishida, S., Yamamoto, H., Murai, H., Koyama, S., & Kikuchi, A. (1998) · The EMBO Journal · doi:10.1093/emboj/17.5.1371 · Cited by 1,248

Stabilization of β-Catenin by Genetic Defects in Melanoma Cell Lines

Rubinfeld, B., Robbins, P. F., El‐Gamil, M., Albert, I., Porfiri, E., & Polakis, P. G. (1997) · Science · doi:10.1126/science.275.5307.1790 · Cited by 1,223

Association of the APC Gene Product with β-Catenin

Rubinfeld, B., Souza, B., Albert, I., Müller, O., Chamberlain, S. H., Masiarz, F. R., Munemitsu, S. M., & Polakis, P. G. (1993) · Science · doi:10.1126/science.8259518 · Cited by 1,223

Association of the APC Tumor Suppressor Protein with Catenins

Su, L.-K., Vogelstein, B., & Kinzler, K. W. (1993) · Science · doi:10.1126/science.8259519 · Cited by 1,193

The kinase TAK1 can activate the NIK-IκB as well as the MAP kinase cascade in the IL-1 signalling pathway

Ninomiya‐Tsuji, J., Kishimoto, K., Hiyama, A., Inoue, J., Cao, Z., & Matsumoto, K. (1999) · Nature · doi:10.1038/18465 · Cited by 1,187

The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3.Preprint

Yost, C., Torres, M., Miller, J., Huang, E., Kimelman, D., & Moon, R. T. (1996) · Genes & Development · doi:10.1101/gad.10.12.1443 · Cited by 1,167

Somatic mutations of the β-catenin gene are frequent in mouse and human hepatocellular carcinomas

Coste, A. D. L., Romagnolo, B., Billuart, P., Renard, C.-A., Buendia, M., Soubrane, O., Fabrè, M., Chelly, J., Beldjord, C., Kahn, A., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.15.8847 · Cited by 1,157

The Molecular Basis of Turcot's Syndrome

Hamilton, S. R., Liu, B., Parsons, R. E., Papadopoulos, N., Jen, J., Powell, S. M., Krush, A. J., Berk, T., Cohen, Z., Têtu, B., et al. (1995) · New England Journal of Medicine · doi:10.1056/nejm199503303321302 · Cited by 1,125

De Novo Hair Follicle Morphogenesis and Hair Tumors in Mice Expressing a Truncated β-Catenin in Skin

Gat, U., DasGupta, R., Degenstein, L., & Fuchs, E. (1998) · Cell · doi:10.1016/s0092-8674(00)81631-1 · Cited by 1,089

Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein.

Munemitsu, S. M., Albert, I., Souza, B., Rubinfeld, B., & Polakis, P. G. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.7.3046 · Cited by 1,021

Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer.

Sparks, A. B., Morin, P. J., Vogelstein, B., & Kinzler, K. W. (1998) · PubMed · Cited by 1,008

Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice.Preprint

van Genderen, C., Okamura, R. M., Fariñas, I., Quo, R. G., Parslow, T. G., Bruhn, L., & Grosschedl, R. (1994) · Genes & Development · doi:10.1101/gad.8.22.2691 · Cited by 972

AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1

Satoh, S., Daigo, Y., Furukawa, Y., Kato, T., Miwa, N., Nishiwaki, T., Kawasoe, T., Ishiguro, H., Fujita, M., Tokino, T., et al. (2000) · Nature Genetics · doi:10.1038/73448 · Cited by 960

The Drosophila homology of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless

Rijsewijk, F. A. M., Schuermann, M., Wagenaar, E., Parren, P. W. H. I., Weigel, D., & Nusse, R. (1987) · Cell · doi:10.1016/0092-8674(87)90038-9 · Cited by 931

Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene

Mori, Y., Nagse, H., Ando, H., Horii, A., Ichii, S., Nakatsuru, S., Aoki, T., Miki, Y., Mori, T., & Nakamura, Y. (1992) · Human Molecular Genetics · doi:10.1093/hmg/1.4.229 · Cited by 931

The Mouse Locus Encodes Axin, an Inhibitor of the Wnt Signaling Pathway That Regulates Embryonic Axis Formation

Zeng, L., Fagotto, F., Zhang, T., Hsu, W., Vasicek, T. J., Perry, W. L., Lee, J. J., Tilghman, S. M., Gumbiner, B. M., & Costantini, F. D. (1997) · Cell · doi:10.1016/s0092-8674(00)80324-4 · Cited by 907

Nuclear localization of β-catenin by interaction with transcription factor LEF-1

Huber, O., Korn, R., McLaughlin, J., Ohsugi, M., Herrmann, B. G., & Kemler, R. (1996) · Mechanisms of Development · doi:10.1016/0925-4773(96)00597-7 · Cited by 855

Downregulation of β-catenin by human Axin and its association with the APC tumor suppressor, β-catenin and GSK3β

Hart, M. J., Santos, R. D. L., Albert, I., Rubinfeld, B., & Polakis, P. G. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70226-x · Cited by 850

A new secreted protein that binds to Wnt proteins and inhibits their activites

Hsieh, J.-C., Kodjabachian, L., Rebbert, M. L., Rattner, A., Smallwood, P. M., Samos, C. H., Nusse, R., Dawid, I. B., & Nathans, J. (1999) · Nature · doi:10.1038/18899 · Cited by 750

Frzb-1 Is a Secreted Antagonist of Wnt Signaling Expressed in the Spemann Organizer

Leyns, L., Bouwmeester, T., Kim, S., Piccolo, S., & Robertis, E. M. D. (1997) · Cell · doi:10.1016/s0092-8674(00)81921-2 · Cited by 736

Drosophila Tcf and Groucho interact to repress Wingless signalling activity

Cavallo, R. A., Cox, R. T., Moline, M. M., Roose, J., Polevoy, G. A., Clevers, H., Peifer, M., & Bejsovec, A. (1998) · Nature · doi:10.1038/26982 · Cited by 730

Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC

Laken, S. J., Petersen, G. M., Gruber, S. B., Oddoux, C., D, H. O. M., Giardiello, F. M., Hamilton, S. R., Hampel, H., Markowitz, A. J., Klimstra, D. S., et al. (1997) · Nature Genetics · doi:10.1038/ng0997-79 · Cited by 676

The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors

Roose, J. P., Molenaar, M., Peterson, J., Hurenkamp, J., Brantjes, H., Moerer, P., van de Wetering, M., Destrée, O., & Clevers, H. C. (1998) · Nature · doi:10.1038/26989 · Cited by 674

The F-box protein β-TrCP associates with phosphorylated β-catenin and regulates its activity in the cell

Hart, M. J., Concordet, J., Lassot, I., Albert, I., Santos, R., Durand, H., Perret, C., Rubinfeld, B., Margottin-Goguet, F., Bénarous, R., et al. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80091-8 · Cited by 670

Wnt Signaling and an APC-Related Gene Specify Endoderm in Early C. elegans Embryos

Rocheleau, C. E., Downs, W. D., Lin, R., Wittmann, C., Bei, Y., Cha, Y.-H., Ali, M., Priess, J. R., & Mello, C. C. (1997) · Cell · doi:10.1016/s0092-8674(00)80531-0 · Cited by 660

The oncogenic activation of β-catenin

Polakis, P. G. (1999) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(99)80003-3 · Cited by 651

The TAK1–NLK–MAPK-related pathway antagonizes signalling between β-catenin and transcription factor TCF

Ishitani, T., Ninomiya-Tsuji, J., Nagai, S.-I., Nishita, M., Meneghini, M., Barker, N., Waterman, M., Bowerman, B., Clevers, H., Shibuya, H., et al. (1999) · Nature · doi:10.1038/21674 · Cited by 621

A common human skin tumour is caused by activating mutations in β-catenin

Chan, E., Gat, U., McNiff, J. M., & Fuchs, E. (1999) · Nature Genetics · doi:10.1038/7747 · Cited by 612

The p300/CBP acetyltransferases function as transcriptional coactivators of β‐catenin in vertebrates

Hecht, A., Vleminckx, K., Stemmler, M. P., Roy, F. M. V., & Kemler, R. (2000) · The EMBO Journal · doi:10.1093/emboj/19.8.1839 · Cited by 602

Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene.

Oshima, M., Oshima, H., Kitagawa, K., Kobayashi, M., Itakura, C., & Taketo, M. M. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.10.4482 · Cited by 558

Regulation of LEF-1/TCF transcription factors by Wnt and other signals

Eastman, Q., & Grosschedl, R. (1999) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(99)80031-3 · Cited by 544

Frzb, a Secreted Protein Expressed in the Spemann Organizer, Binds and Inhibits Wnt-8

Wang, S., Krinks, M., Lin, K., Luyten, F. P., & Moos, M. (1997) · Cell · doi:10.1016/s0092-8674(00)81922-4 · Cited by 518 · cited 2×

pangolinencodes a Lef-1 homologue that acts downstream of Armadillo to transduce the Wingless signal in Drosophila

Brunner, E., Peter, O., Schweizer, L., & Basler, K. (1997) · Nature · doi:10.1038/385829a0 · Cited by 493

A Member of the Frizzled Protein Family Mediating Axis Induction by Wnt-5A

He, X., Saint‐Jeannet, J., Wang, Y., Nathans, J., Dawid, I. B., & VARMUS, H. E. (1997) · Science · doi:10.1126/science.275.5306.1652 · Cited by 493

Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos

He, X., Saint‐Jeannet, J., Woodgett, J. R., VARMUS, H. E., & Dawid, I. B. (1995) · Nature · doi:10.1038/374617a0 · Cited by 484

The Transcriptional Coactivator Cbp Interacts with β-Catenin to Activate Gene Expression

Takemaru, K., & Moon, R. T. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.149.2.249 · Cited by 481

Protein kinase C is differentially stimulated by Wnt and Frizzled homologs in aG-protein-dependent manner

Sheldahl, L. C., Park, M., Malbon, C. C., & Moon, R. T. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80310-8 · Cited by 475

A frizzled homolog functions in a vertebrate Wnt signaling pathway

Yang-Snyder, J., Miller, J. R., Brown, J. D., Lai, C.-J., & Moon, R. T. (1996) · Current Biology · doi:10.1016/s0960-9822(02)70716-1 · Cited by 469

Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors

Levanon, D., Goldstein, R. E., Bernstein, Y., Tang, H., Goldenberg, D., Stifani, S., Paroush, Z., & Groner, Y. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.20.11590 · Cited by 467

Interaction between Wnt and TGF-β signalling pathways during formation of Spemann's organizer

Nishita, M., Hashimoto, M. K., Ogata, S., Laurent, M. N., Ueno, N., Shibuyà, H., & Cho, K. W. Y. (2000) · Nature · doi:10.1038/35001602 · Cited by 466

LEF-1, a nuclear factor coordinating signaling inputs from wingless and decapentaplegic.

Riese, J., Yu, X., Munnerlyn, A., Eresh, S., Hsu, S.-C., Grosschedl, R., & Bienz, M. (1997) · Cell · doi:10.1016/s0092-8674(00)81924-8 · Cited by 465

Synergy Between Tumor Suppressor APC and the β-Catenin-Tcf4 Target Tcf1

Roose, J. P., Huls, G. A., van Beest, M., Moerer, P., van der Horn, K., Goldschmeding, R., Logtenberg, T., & Clevers, H. C. (1999) · Science · doi:10.1126/science.285.5435.1923 · Cited by 456

Casein kinase I transduces Wnt signals

Peters, J. M., McKay, R. M., McKay, J. P., & Graff, J. M. (1999) · Nature · doi:10.1038/43830 · Cited by 447

Activation of the beta-catenin gene in primary hepatocellular carcinomas by somatic alterations involving exon 3.

Miyoshi, Y., Iwao, K., Nagasawa, Y., Aihara, T., Sasaki, Y., Imaoka, S., Murata, M., Shimano, T., & Nakamura, Y. (1998) · PubMed · Cited by 432

Regulation of β-Catenin Signaling by the B56 Subunit of Protein Phosphatase 2A

Seeling, J. M., Miller, J. R., Gil, R., Moon, R. T., White, R. L., & Virshup, D. M. (1999) · Science · doi:10.1126/science.283.5410.2089 · Cited by 427

Transformation by Wnt family proteins correlates with regulation of beta-catenin.

Shimizu, H., Julius, M. A., Giarrè, M., Zheng, Z., Brown, A. M. C., & Kitajewski, J. (1997) · PubMed · Cited by 409

Secreted Frizzled-related Protein-1 Binds Directly to Wingless and Is a Biphasic Modulator of Wnt Signaling

Üren, A., Reichsman, F., Anest, V., Taylor, W. G., Muraiso, K., Bottaro, D. P., Cumberledge, S., & Rubin, J. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.6.4374 · Cited by 408

DIX Domains of Dvl and Axin Are Necessary for Protein Interactions and Their Ability To Regulate β-Catenin Stability

Kishida, S., Yamamoto, H., Hino, S.-I., Ikeda, S., Kishida, M., & Kikuchi, A. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.6.4414 · Cited by 406

Axin and Frat1 interact with Dvl and GSK, bridging Dvl to GSK in Wnt‐mediated regulation of LEF‐1

Li, L., Yuan, H., Weaver, C. D., Mao, J., Farr, G. H., Sussman, D. J., Jonkers, J., Kimelman, D., & Wu, D. (1999) · The EMBO Journal · doi:10.1093/emboj/18.15.4233 · Cited by 403

Casein Kinase IIα Transgene-Induced Murine Lymphoma: Relation to Theileriosis in Cattle

Seldin, D. C., & Leder, P. (1995) · Science · doi:10.1126/science.7846532 · Cited by 400

Childhood hepatoblastomas frequently carry a mutated degradation targeting box of the beta-catenin gene.

Koch, A., Denkhaus, D., Albrecht, S., Leuschner, I., von Schweinitz, D., & Pietsch, T. (1999) · PubMed · Cited by 399

Sporadic medulloblastomas contain oncogenic beta-catenin mutations.

Zurawel, R. H., CHIAPPA, S. A., Allen, C., & Raffel, C. (1998) · PubMed · Cited by 387

dishevelled and armadillo act in the Wingless signalling pathway in Drosophila

Noordermeer, J. N., Klingensmith, J., Perrimon, N., & Nusse, R. (1994) · Nature · doi:10.1038/367080a0 · Cited by 378

The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis

Lamlum, H., Ilyas, M., Rowan, A., Clark, S. K., Johnson, V., Bell, J., Frayling, I. M., Efstathiou, J. A., Pack, K., Payne, S. J., et al. (1999) · Nature Medicine · doi:10.1038/12511 · Cited by 374

Beta-catenin mutations in human prostate cancer.

Voeller, H. J., Truica, C., & Gelmann, E. P. (1998) · PubMed · Cited by 365

Drosophila CBP represses the transcription factor TCF to antagonize Wingless signalling

Waltzer, L., & Bienz, M. (1998) · Nature · doi:10.1038/26785 · Cited by 364

Phosphorylation of Axin, a Wnt Signal Negative Regulator, by Glycogen Synthase Kinase-3β Regulates Its Stability

Yamamoto, H., Kishida, S., Kishida, M., Ikeda, S., Takada, S., & Kikuchi, A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.16.10681 · Cited by 364

Alterations of the PPP2R1B Gene in Human Lung and Colon Cancer

Wang, S. S., Esplin, E. D., Li, J. L., Huang, L., Gazdar, A. F., Minna, J. D., & Evans, G. A. (1998) · Science · doi:10.1126/science.282.5387.284 · Cited by 363

Beta-catenin mutation in carcinoma of the uterine endometrium.

Fukuchi, T., Sakamoto, M., Tsuda, H., Maruyama, K., Nozawa, S., & Hirohashi, S. (1998) · PubMed · Cited by 361

Interaction of Frizzled Related Protein (FRP) with Wnt Ligands and the Frizzled Receptor Suggests Alternative Mechanisms for FRP Inhibition of Wnt Signaling

Bafico, A., Gazit, A., Tata, P., Finch, P. W., Yaniv, A., & Aaronson, S. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.23.16180 · Cited by 353

Predominance of beta-catenin mutations and beta-catenin dysregulation in sporadic aggressive fibromatosis (desmoid tumor)

Tejpar, S., Nollet, F., Li, C., Wunder, J. S., Michils, G., Cin, P. D., Cutsem, E. V., Bapat, B. V., Roy, F. M. V., Cassiman, J. J., et al. (1999) · Oncogene · doi:10.1038/sj.onc.1203041 · Cited by 344

Mutations in the beta-catenin gene (CTNNB1) in endometrioid ovarian carcinomas.

Palacios, J., & Gamallo, C. (1998) · PubMed · Cited by 344

Correlation between the location of germ-line mutations in the APC gene and the number of colorectal polyps in familial adenomatous polyposis patients.

Nagase, H., Miyoshi, Y., Horii, A., Aoki, T., Ogawa, M., Utsunomiya, J., Baba, S., Sasazuki, T., & Nakamura, Y. (1992) · PubMed · Cited by 344

Regulation of Wnt Signaling by Sox Proteins

Zorn, A. M., Barish, G. D., Williams, B. O., Lavender, P., Klymkowsky, M. W., & VARMUS, H. E. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80200-2 · Cited by 342

Wnt-induced dephosphorylation of Axin releases beta -catenin from the Axin complexPreprint

Willert, K., Shibamoto, S., & Nusse, R. (1999) · Genes & Development · doi:10.1101/gad.13.14.1768 · Cited by 337

Control of β-Catenin Stability

Salic, A., Lee, E., Mayer, L., & Kirschner, M. W. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80446-3 · Cited by 335

Amplification and overexpression of the cyclin D1 gene in aggressive human hepatocellular carcinoma.

Nishida, N., Fukuda, Y., Komeda, T., Kita, R., Sando, T., Furukawa, M., Amenomori, M., Shibagaki, I., Nakao, K., & Ikenaga, M. (1994) · PubMed · Cited by 330

GBP, an Inhibitor of GSK-3, Is Implicated in Xenopus Development and Oncogenesis

Yost, C., Farr, G. H., Pierce, S. B., Ferkey, D. M., Chen, M. M., & Kimelman, D. (1998) · Cell · doi:10.1016/s0092-8674(00)81208-8 · Cited by 328

SARPs: A family of secreted apoptosis-related proteins

Melkonyan, H. S., Chang, W. C., Shapiro, J. P., Mahadevappa, M., Fitzpatrick, P., Kiefer, M. C., Tomei, L., & Umansky, S. R. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.25.13636 · Cited by 326

Increased beta-catenin protein and somatic APC mutations in sporadic aggressive fibromatoses (desmoid tumors).

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Role of glycogen synthase kinase 3 beta as a negative regulator of dorsoventral axis formation in Xenopus embryos.

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