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Wnt signaling and cancer
Open accessAbstract
The regulation of cell growth and survival can be subverted by a variety of genetic defects that alter transcriptional programs normally responsible for controlling cell number. High throughput analysis of these gene expression patterns should ultimately lead to the identification of minimal expression profiles that will serve as common denominators in assigning a cancer to a given category. In the course of defining the common denominators, though, we should not be too surprised to find that cancers within a single category may nevertheless exhibit seemingly disparate genetic defects. The wnt pathway has already provided an outstanding example of this. We now know of three regulatory genes in this pathway that are mutated in primary human cancers and several others that promote experimental cancers in rodents (Fig. 1). In all of these cases the common denominator is the activation of gene transcription by -catenin. The resulting gene expression profile should provide us with a signature common to those cancers carrying defects in the wnt pathway. In this review, the wnt pathway will be covered from the perspective of cancer, with emphasis placed on molecular defects known to promote neoplastic transformation in humans and in animal models.
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“Constitutive activation of this pathway is also implicated in cancer development in several other organs (140).”
From Adrenal incidentaloma (2020) · cites this paper as [140]
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Metadata
- Authors
- Polakis, P.
- Affiliations
- Genentech (US)
- Corresponding author
- Polakis, Paul
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2000-08-01
- Volume
- 14
- Issue
- 15
- Pages
- 1837-1851
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2239090104
- Cited by
- 3,183
- References
- 190
- Citations by year
- 2026: 6 · 2025: 12 · 2024: 25 · 2023: 43 · 2022: 39 · 2021: 46 · 2020: 56 · 2019: 67 · 2018: 71 · 2017: 86 · 2016: 110 · 2015: 144 · 2014: 138 · 2013: 147 · 2012: 174
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
- Keywords
- Wnt signaling, β-catenin, cancer, oncogenic transformation, transcriptional activation, gene expression profiles, experimental tumor model
- MeSH terms
- Dishevelled Proteins, Animals, Cytoskeletal Proteins, Humans, Neoplasms, Phosphoprotein Phosphatases, Phosphoproteins, Proto-Oncogene Proteins, Transcription Factors, Signal Transduction, Trans-Activators, Calcium-Calmodulin-Dependent Protein Kinases, Adenomatous Polyposis Coli Protein, Zebrafish Proteins, Glycogen Synthase Kinase 3, Adaptor Proteins, Signal Transducing, Wnt Proteins, beta Catenin
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