PreprintCited by 3,183Wnt/β-catenin signaling in development and cancerSignaling Pathways in DiseaseHedgehog Signaling Pathway Studies

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Wnt signaling and cancer

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Polakis, Paul·2000·Genes & Development

DOI 10.1101/gad.14.15.1837

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Abstract

The regulation of cell growth and survival can be subverted by a variety of genetic defects that alter transcriptional programs normally responsible for controlling cell number. High throughput analysis of these gene expression patterns should ultimately lead to the identification of minimal expression profiles that will serve as common denominators in assigning a cancer to a given category. In the course of defining the common denominators, though, we should not be too surprised to find that cancers within a single category may nevertheless exhibit seemingly disparate genetic defects. The wnt pathway has already provided an outstanding example of this. We now know of three regulatory genes in this pathway that are mutated in primary human cancers and several others that promote experimental cancers in rodents (Fig. 1). In all of these cases the common denominator is the activation of gene transcription by -catenin. The resulting gene expression profile should provide us with a signature common to those cancers carrying defects in the wnt pathway. In this review, the wnt pathway will be covered from the perspective of cancer, with emphasis placed on molecular defects known to promote neoplastic transformation in humans and in animal models.

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Identification of c- MYC as a Target of the APC Pathway
He, T.-C., Sparks, A. B., Rago, C., Hermeking, H., Zawel, L., da Costa, L. T., Morin, P. J., Vogelstein, B., & Kinzler, K. W. (1998) · Science · doi:10.1126/science.281.5382.1509 · Cited by 4,566
Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC
Morin, P. J., Sparks, A. B., Kořínek, V., Barker, N., Clevers, H. C., Vogelstein, B., & Kinzler, K. W. (1997) · Science · doi:10.1126/science.275.5307.1787 · Cited by 4,000
β-Catenin regulates expression of cyclin D1 in colon carcinoma cells
Tetsu, O., & McCormick, F. (1999) · Nature · doi:10.1038/18884 · Cited by 3,601
Functional interaction of β-catenin with the transcription factor LEF-1
Behrens, J., von Kries, J. P., Kühl, M., Bruhn, L., Wedlich, D., Grosschedl, R., & Birchmeier, W. (1996) · Nature · doi:10.1038/382638a0 · Cited by 2,912
Identification and characterization of the familial adenomatous polyposis coli gene
Groden, J. L., Thliveris, A. T., Samowitz, W. S., Carlson, M. L., Gelbert, L. M., Albertsen, H., Joslyn, G., Stevens, J., Spirio, L. N., Robertson, M. A., et al. (1991) · Cell · doi:10.1016/0092-8674(81)90021-0 · Cited by 2,794
Identification of FAP Locus Genes from Chromosome 5q21
Kinzler, K. W., Nilbert, M. C., Su, L.-K., Vogelstein, B., Bryan, T. M., Levy, D. B., Smith, K. J., Preisinger, A. C., Hedge, P., McKechnie, D., et al. (1991) · Science · doi:10.1126/science.1651562 · Cited by 2,331
The cyclin D1 gene is a target of the β-catenin/LEF-1 pathway
Shtutman, M., Zhurinsky, J., Simcha, I., Albanese, C., D’Amico, M., Pestell, R., & Ben-Ze’ev, A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.10.5522 · Cited by 2,230
MECHANISMS OF WNT SIGNALING IN DEVELOPMENT
Wodarz, A., & Nusse, R. (1998) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.14.1.59 · Cited by 2,030
Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome
Nusse, R., & VARMUS, H. E. (1982) · Cell · doi:10.1016/0092-8674(82)90409-3 · Cited by 1,864
XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos
Molenaar, M., van de Wetering, M., Oosterwegel, M., Peterson-Maduro, J., Godsave, S., Korinek, V., Roose, J., Destrée, O., & Clevers, H. (1996) · Cell · doi:10.1016/s0092-8674(00)80112-9 · Cited by 1,824

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FGF‐20 and DKK1 are transcriptional targets of β‐catenin and FGF‐20 is implicated in cancer and development
Chamorro, M., Schwartz, D. R., Vonica, A., Brivanlou, A. H., Cho, K. R., & VARMUS, H. E. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600460 · Cited by 300
Expression of ΔNLef1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumours
Niemann, C., Owens, D. M., Hülsken, J., Birchmeier, W., & Watt, F. M. (2002) · Development · doi:10.1242/dev.129.1.95 · Cited by 298
Cdc42 and Par6–PKCζ regulate the spatially localized association of Dlg1 and APC to control cell polarization
Etienne‐Manneville, S., Manneville, J., Nicholls, S., Ferenczi, M. A., & Hall, A. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200412172 · Cited by 308
Medulloblastoma: signalling a change in treatment
Gilbertson, R. J. (2004) · The Lancet Oncology · doi:10.1016/s1470-2045(04)01424-x · Cited by 297
Intrinsic disorder in scaffold proteins: Getting more from less
Cortese, M. S., Uversky, V. N., & Dunker, A. K. (2008) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2008.05.007 · Cited by 301
Small interfering RNAs directed against beta-catenin inhibit the in vitro and in vivo growth of colon cancer cells.
Verma, U. N., Surabhi, R. M., Schmaltieg, A., Becerra, C. R., & Gaynor, R. B. (2003) · PubMed · Cited by 294
Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism
Ayyanan, A., Civenni, G., Ciarloni, L., Morel, C., Mueller, N., Lefort, K., Mandinova, A., Raffoul, W., Fiche, M., Dotto, G. P., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600065103 · Cited by 299
The transforming activity of Wnt effectors correlates with their ability to induce the accumulation of mammary progenitor cells
Liu, B. Y., McDermott, S., Khwaja, S. S., & Alexander, C. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400699101 · Cited by 297
β-Catenin–induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor
Widlund, H. R., Horstmann, M. A., Price, E. R., Cui, J., Lessnick, S. L., Wu, M., He, X., & Fisher, D. E. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200202049 · Cited by 292
Regulation of GSK-3
Harwood, A. J. (2001) · Cell · doi:10.1016/s0092-8674(01)00412-3 · Cited by 291
The canonical Wnt signalling pathway and its APC partner in colon cancer development
Schneikert, J., & Behrens, J. (2006) · Gut · doi:10.1136/gut.2006.093310 · Cited by 302
A Role of Dishevelled in Relocating Axin to the Plasma Membrane during Wingless Signaling
Cliffe, A., Hamada, F., & Bienz, M. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00370-1 · Cited by 289
Mediator Is a Transducer of Wnt/β-Catenin Signaling
Kim, S., Xu, X., Hecht, A., & Boyer, T. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602696200 · Cited by 298
Mouse Cristin/R-spondin Family Proteins Are Novel Ligands for the Frizzled 8 and LRP6 Receptors and Activate β-Catenin-dependent Gene Expression
Nam, J., Turcotte, T. J., Smith, P. F., Choi, S., & Yoon, J. K. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m508324200 · Cited by 288
Tankyrase-targeted therapeutics: expanding opportunities in the PARP family
Riffell, J. L., Lord, C. J., & Ashworth, A. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3868 · Cited by 303
A new nuclear component of the Wnt signalling pathway
Thompson, B. J., Townsley, F. M., Rosin‐Arbesfeld, R., Musisi, H., & Bienz, M. (2002) · Nature Cell Biology · doi:10.1038/ncb786 · Cited by 288
The ins and outs of APC and β‐catenin nuclear transport
Henderson, B. R., & Fagotto, F. (2002) · EMBO Reports · doi:10.1093/embo-reports/kvf181 · Cited by 296
Multiplicity of the interactions of Wnt proteins and their receptors
Kikuchi, A., Yamamoto, H., & Kishida, S. (2006) · Cellular Signalling · doi:10.1016/j.cellsig.2006.11.001 · Cited by 289
Expression of Concern: Up‐regulation of Wnt‐1 and β‐catenin production in patients with advanced metastatic prostate carcinoma
Chen, G., Shukeir, N., Potti, A., Sircar, K., Aprikian, A., Goltzman, D., & Rabbani, S. A. (2004) · Cancer · doi:10.1002/cncr.20518 · Cited by 283
Ubiquitin Ligases and the Immune Response
Liu, Y. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104813 · Cited by 286
Structural basis for recruitment of glycogen synthase kinase 3β to the axin—APC scaffold complex
Dajani, R., Fraser, E., Roe, S. M., Yeo, M., Good, V. M., Thompson, V., Dale, T. C., & Pearl, L. H. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg068 · Cited by 315
Chemoprevention by isothiocyanates and their underlying molecular signaling mechanisms
Keum, Y., Jeong, W., & Kong, A. (2004) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2004.05.024 · Cited by 285
Potential mechanisms of quercetin in cancer prevention: focus on cellular and molecular targets
Asgharian, P., Tazehkand, A. P., Hosseini, K., Forouhandeh, H., Ghasemnejad, T., Ranjbar, M., Hasan, M., Kumar, M., Beirami, S. M., Tarhriz, V., et al. (2022) · Cancer Cell International · doi:10.1186/s12935-022-02677-w · Cited by 307
“The loss of Wnt signalling regulation is frequently correlated with tumor progression and metastasis [36].”
Background
Liver‐specific loss of β‐catenin blocks glutamine synthesis pathway activity and cytochrome p450 expression in mice†‡
Sekine, S., Lan, B. Y., Bedolli, M., Feng, S., & Hebrok, M. (2006) · Hepatology · doi:10.1002/hep.21131 · Cited by 295
Heads or tails: Wnts and anterior–posterior patterning
Yamaguchi, T. P. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00417-1 · Cited by 276
The CK1 Family: Contribution to Cellular Stress Response and Its Role in Carcinogenesis
Knippschild, U., KrÃ¼ger, M., Richter, J., Xu, P., García-Reyes, B., Peifer, C., Halekotte, J., Bakulev, V. A., & Bischof, J. (2014) · Frontiers in Oncology · doi:10.3389/fonc.2014.00096 · Cited by 280
Cell Cycle Control of Wnt Receptor Activation
Davidson, G. R., Shen, J., Huang, Y., Su, Y., Karaulanov, E., Bartscherer, K., Hassler, C., Stannek, P., Boutros, M., & Niehrs, C. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.11.006 · Cited by 284
The significance of the Wnt pathway in the pathology of human cancers
Karim, R. Z., Tse, G. M.-K., Putti, T. C., Scolyer, R. A., & Lee, C. S. (2004) · Pathology · doi:10.1080/00313020410001671957 · Cited by 276
The Wnts.
Miller, J. R. (2001) · Genome biology · doi:10.1186/gb-2001-3-1-reviews3001 · Cited by 275
Chibby, a nuclear β-catenin-associated antagonist of the Wnt/Wingless pathway
Takemaru, K., Yamaguchi, S., Lee, Y. S., Zhang, Y., Carthew, R. W., & Moon, R. T. (2003) · Nature · doi:10.1038/nature01570 · Cited by 274
Molecular Pathogenesis of Osteosarcoma
Kansara, M., & Thomas, D. M. (2007) · DNA and Cell Biology · doi:10.1089/dna.2006.0505 · Cited by 280
beta-Catenin regulates vascular endothelial growth factor expression in colon cancer.
Easwaran, V., Lee, S. H., Inge, L. J., Guo, L., Goldbeck, C., Garrett, E. N., Wiesmann, M., García, P. D., Fuller, J. H., Chan, V. W.-F., et al. (2003) · PubMed · Cited by 272
EGF-Induced ERK Activation Promotes CK2-Mediated Disassociation of α-Catenin from β-Catenin and Transactivation of β-Catenin
Ji, H., Wang, J., Nika, H., Hawke, D., Keezer, S., Ge, Q., Fang, B., Fang, X., Fang, D., Litchfield, D. W., et al. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.09.034 · Cited by 270
Interaction of FOXO with β-Catenin Inhibits β-Catenin/T Cell Factor Activity
Hoogeboom, D., Essers, M. A. G., Polderman, P. E., Voets, E., Smits, L. M. M., & Burgering, B. M. T. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m706638200 · Cited by 274
Common mutations of β-catenin in adamantinomatous craniopharyngiomas but not in other tumours originating from the sellar region
Buslei, R., Nolde, M., Hofmann, B., Meissner, S., Eyüpoglu, I. Y., Siebzehnrübl, F. A., Hahnen, E., Kreutzer, J., & Fahlbusch, R. (2005) · Acta Neuropathologica · doi:10.1007/s00401-005-1004-x · Cited by 271
Wnt Inhibitory Factor-1 Is Silenced by Promoter Hypermethylation in Human Lung Cancer
Mazières, J., He, B., You, L., Xu, Z., Lee, A. Y., Mikami, I., Reguart, N., Rosell, R., McCormick, F. P., & Jablons, D. M. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1389 · Cited by 271
A Monoclonal Antibody against Wnt-1 Induces Apoptosis in Human Cancer Cells
He, B., You, L., Uematsu, K., Xu, Z., Lee, A. Y., Matsangou, M., McCormick, F. P., & Jablons, D. M. (2004) · Neoplasia · doi:10.1016/s1476-5586(04)80048-4 · Cited by 270
The Cadherin Cytoplasmic Domain Is Unstructured in the Absence of β-Catenin
Huber, A. H., Stewart, D. B., Laurents, D. V., Nelson, W. J., & Weis, W. I. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010377200 · Cited by 268
Tumor Suppressor Pten Inhibits Nuclear Accumulation of β-Catenin and T Cell/Lymphoid Enhancer Factor 1–Mediated Transcriptional Activation
Persad, S., Troussard, A. A., McPhee, T. R., Mulholland, D. J., & Dedhar, S. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.153.6.1161 · Cited by 269
Cell adhesion in tumor invasion and metastasis: loss of the glue is not enough
Cavallaro, U., & Christofori, G. (2001) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(01)00038-5 · Cited by 271
Wnt Signalling in Implantation, Decidualisation and Placental Differentiation – Review
Sonderegger, S., Pollheimer, J., & Knöfler, M. (2010) · Placenta · doi:10.1016/j.placenta.2010.07.011 · Cited by 271
Transient activation of β-catenin signaling in cutaneous keratinocytes is sufficient to trigger the active growth phase of the hair cycle in mice
Van Mater, D., Kolligs, F. T., Dlugosz, A. A., & Fearon, E. R. (2003) · Genes & Development · doi:10.1101/gad.1076103 · Cited by 263
Activated β-catenin induces osteoblast differentiation of C3H10T1/2 cells and participates in BMP2 mediated signal transduction
Bain, G., Müller, T. H., Wang, X., & Papkoff, J. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02951-0 · Cited by 262
Dickkopf 3 Inhibits Invasion and Motility of Saos-2 Osteosarcoma Cells by Modulating the Wnt-β-Catenin Pathway
Hoang, B. H., Kubo, T., Healey, J. H., Yang, R., Nathan, S. S., Kolb, E. A., Mazza, B., Meyers, P. A., & Gorlick, R. G. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-1952 · Cited by 261
GSK-3β regulates cyclin D1 expression: A new target for chemotherapy
Takahashi‐Yanaga, F., & Sasaguri, T. (2007) · Cellular Signalling · doi:10.1016/j.cellsig.2007.10.018 · Cited by 262
Tamoxifen resistance in MCF7 cells promotes EMT-like behaviour and involves modulation of β-catenin phosphorylation
Hiscox, S., Jiang, W. G., Obermeier, K., Taylor, K. M., Morgan, L. D., Burmi, R. S., Barrow, D., & Nicholson, R. I. (2005) · International Journal of Cancer · doi:10.1002/ijc.21355 · Cited by 259
Inhibition of Wnt-2-mediated signaling induces programmed cell death in non-small-cell lung cancer cells
You, L., He, B., Xu, Z., Uematsu, K., Mazières, J., Mikami, I., Reguart, N., Moody, T. W., Kitajewski, J., McCormick, F. P., et al. (2004) · Oncogene · doi:10.1038/sj.onc.1207844 · Cited by 258
Tumor formation by genetic mutations in the components of the Wnt signaling pathway
Kikuchi, A. (2003) · Cancer Science · doi:10.1111/j.1349-7006.2003.tb01424.x · Cited by 258
Wnt5ais required for proper epithelial-mesenchymal interactions in the uterus
Mericskay, M., Kitajewski, J., & Sassoon, D. A. (2004) · Development · doi:10.1242/dev.01090 · Cited by 267
Downregulated MicroRNA-200a in Meningiomas Promotes Tumor Growth by Reducing E-Cadherin and Activating the Wnt/β-Catenin Signaling Pathway
Saydam, O., Shen, Y., Würdinger, T., Senol, O., Böke, E., James, M. F., Tannous, B. A., Stemmer-Rachamimov, A. O., Yi, M., Stephens, R. M., et al. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00332-09 · Cited by 257
Diverse mechanisms of beta-catenin deregulation in ovarian endometrioid adenocarcinomas.
WU, R. T., Zhai, Y., Fearon, E. R., & Cho, K. R. (2001) · PubMed · Cited by 256
The role of growth factors in tooth development
Thesleff, I., & Mikkola, M. L. (2002) · International review of cytology · doi:10.1016/s0074-7696(02)17013-6 · Cited by 255
Changing neighbours, changing behaviour: cell adhesion molecule‐mediated signalling during tumour progression
Christofori, G. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg228 · Cited by 254
Aberrant methylation of the Wnt antagonist SFRP1 in breast cancer is associated with unfavourable prognosis
Veeck, J., Niederacher, D., An, H., Klopocki, E., Wiesmann, F., Betz, B., Galm, O., Camara, O., Dürst, M., Kristiansen, G., et al. (2006) · Oncogene · doi:10.1038/sj.onc.1209386 · Cited by 258
THE ADENOMATOUS POLYPOSIS COLI PROTEIN: The Achilles Heel of the Gut Epithelium
Näthke, I. S. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.012103.094541 · Cited by 256
A central role for cadherin signaling in cancer
Kourtidis, A., Lu, R., Pence, L. J., & Anastasiadis, P. Z. (2017) · Experimental Cell Research · doi:10.1016/j.yexcr.2017.04.006 · Cited by 262
Design of Triazole-Stapled BCL9 α-Helical Peptides to Target the β-Catenin/B-Cell CLL/lymphoma 9 (BCL9) Protein–Protein Interaction
Kawamoto, S. A., Coleska, A., Xu, R., Han, Y., Yang, C., & Wang, S. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm201125d · Cited by 254
Wnt/β-Catenin and Fgf Signaling Control Collective Cell Migration by Restricting Chemokine Receptor Expression
Aman, A. J., & Piotrowski, T. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.10.002 · Cited by 257
In vivo base editing of post-mitotic sensory cells
Yeh, W.-H., Chiang, H., Rees, H. A., Edge, A. S. B., & Liu, D. R. (2018) · Nature Communications · doi:10.1038/s41467-018-04580-3 · Cited by 225
The links between axin and carcinogenesis
Salahshor, S., & Woodgett, J. R. (2005) · Journal of Clinical Pathology · doi:10.1136/jcp.2003.009506 · Cited by 256
G Protein Signaling from Activated Rat Frizzled-1 to the β-Catenin-Lef-Tcf Pathway
Liu, T., DeCostanzo, A. J., Liu, X., Wang, H., Hallagan, S. E., Moon, R. T., & Malbon, C. C. (2001) · Science · doi:10.1126/science.1060100 · Cited by 249
Wnt Proteins in Mammary Development and Cancer
Brennan, K. R., & Brown, A. M. C. (2004) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1023/b:jomg.0000037157.94207.33 · Cited by 247
Antagonism of miR-21 Reverses Epithelial-Mesenchymal Transition and Cancer Stem Cell Phenotype through AKT/ERK1/2 Inactivation by Targeting PTEN
Han, M., Liu, M., Wang, Y., Chen, X., Xu, J., Sun, Y., Zhao, L., Qu, H., Fan, Y., & Wu, C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039520 · Cited by 255
“On the molecular level, cells undergoing EMT towards a more mesenchymal phenotype involves loss or lowered the expression of epithelial markers such as E-cadherin, and increased the expression of mesenchymal markers such as Ncadherin, Vimentin, and alpha-SMA [2,4,5].”
Background
Dapper, a Dishevelled-Associated Antagonist of β-Catenin and JNK Signaling, Is Required for Notochord Formation
Cheyette, B. N. R., Waxman, J. S., Miller, J. R., Takemaru, K., Sheldahl, L. C., Khlebtsova, N., Fox, E. P., Earnest, T. N., & Moon, R. T. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00140-5 · Cited by 254
Twist is up-regulated in response to Wnt1 and inhibits mouse mammary cell differentiation.
Howe, L. R., Watanabe, O., Leonard, J. N., & Brown, A. M. C. (2003) · PubMed · Cited by 244
Mechanistic insights from structural studies of β-catenin and its binding partners
Xu, W., & Kimelman, D. (2007) · Journal of Cell Science · doi:10.1242/jcs.013771 · Cited by 255
Wnt signaling in lung cancer
Mazières, J., He, B., You, L., Xu, Z., & Jablons, D. M. (2005) · Cancer Letters · doi:10.1016/j.canlet.2004.08.040 · Cited by 248
Maternal factors in zebrafish development
Pelegri, F. J. (2003) · Developmental Dynamics · doi:10.1002/dvdy.10390 · Cited by 248
The subcellular destinations of apc proteins
Bienz, M. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm806 · Cited by 243
Functional Interaction between Peroxisome Proliferator-Activated Receptor γ and β-Catenin
Liu, J., Wang, H., Zuo, Y., & Farmer, S. R. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00441-06 · Cited by 241
Hepatocyte Nuclear Factor 4α Suppresses the Development of Hepatocellular Carcinoma
Ning, B., Ding, J., Yin, C., Zhong, W. H., Wu, K., Zeng, X. Y., Yang, W. K., Chen, Y.-X., Zhang, J., Zhang, X., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-0824 · Cited by 241
Phospho-regulation of β-Catenin Adhesion and Signaling Functions
Daugherty, R. L., & Gottardi, C. (2007) · Physiology · doi:10.1152/physiol.00020.2007 · Cited by 237
Early development of polycystic kidney disease in transgenic mice expressing an activated mutant of the β-catenin gene
Saadi-Kheddouci, S., Berrebi, D. D., Romagnolo, B., Cluzeaud, F., Peuchmaur, M. M., Kahn, A., Vandewalle, A., & Perret, C. (2001) · Oncogene · doi:10.1038/sj.onc.1204825 · Cited by 241
Quercetin Inhibit Human SW480 Colon Cancer Growth in Association with Inhibition of Cyclin D1and Survivin Expression through Wnt/β-Catenin Signaling Pathway
Shan, B., Wang, M., & Li, R. (2009) · Cancer Investigation · doi:10.1080/07357900802337191 · Cited by 240
Constitutive β-catenin activation induces adrenal hyperplasia and promotes adrenal cancer development
Berthon, A. S., Sahut‐Barnola, I., Lambert-Langlais, S., de Joussineau, C., Damon‐Soubeyrand, C., Louiset, E., Taketo, M. M., Tissier, F., Bertherat, J. Y., Lefrançois‐Martinez, A., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq029 · Cited by 263
Curcumin-induced suppression of adipogenic differentiation is accompanied by activation of Wnt/β-catenin signaling
Ahn, J., Lee, H., Kim, S., & Ha, T. Y. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00369.2009 · Cited by 247
Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer
Suzuki, H., Toyota, M., Caraway, H., Gabrielson, E. W., Ohmura, T., Fujikane, T., Nishikawa, N., Sogabe, Y., Nojima, M., Sonoda, T., et al. (2008) · British Journal of Cancer · doi:10.1038/sj.bjc.6604259 · Cited by 249
Pygopus, a nuclear PHD-finger protein required for Wingless signaling inDrosophila
Parker, D. S., Jemison, J., & Cadigan, K. M. (2002) · Development · doi:10.1242/dev.129.11.2565 · Cited by 238
Role of Rho family GTPases in epithelial morphogenesis.Preprint
Aelst, L. V., & Symons, M. (2002) · Genes & Development · doi:10.1101/gad.978802 · Cited by 247
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Herz, J. (2001) · Neuron · doi:10.1016/s0896-6273(01)00234-3 · Cited by 238
Presenilin Couples the Paired Phosphorylation of β-Catenin Independent of Axin
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RVB1/RVB2: Running Rings around Molecular Biology
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An Antagonist of Dishevelled Protein-Protein Interaction Suppresses β-Catenin–Dependent Tumor Cell Growth
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Wnt / β-Catenin Signaling Pathway as Novel Cancer Drug Targets
Luu, H. H., Zhang, R., Haydon, R. C., Rayburn, E. R., Kang, Q., Si, W., Park, J. K., Wang, H., Peng, Y., Jiang, W., et al. (2004) · Current Cancer Drug Targets · doi:10.2174/1568009043332709 · Cited by 236
MUC1 Oncoprotein Blocks Glycogen Synthase Kinase 3β–Mediated Phosphorylation and Degradation of β-Catenin
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Downregulation of Wnt2 and β-catenin by siRNA suppresses malignant glioma cell growth
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Interferons and progesterone for establishment and maintenance of pregnancy: interactions among novel cell signaling pathways
Bazer, F. W., Burghardt, R. C., Johnson, G. A., Spencer, T. E., & Wu, G. (2008) · Reproductive Biology · doi:10.1016/s1642-431x(12)60012-6 · Cited by 233
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A Rac1/PAK1 cascade controls β-catenin activation in colon cancer cells
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“…cellular processes, including proliferation, during tissue homeostasis and its aberrant activation is implicated with a wide range of human cancers (Polakis, 2000; Logan and Nusse, 2004; Moon et al., 2004; Clevers, 2006; MacDonald et al., 2009). b-catenin is the major cellular effector of the Wnt…”
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Dynamic recruitment of axin by Dishevelled protein assemblies
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Authors: Polakis, P.
Affiliations: Genentech (US)
Corresponding author: Polakis, Paul
Venue: Genes & Development
Publisher: Cold Spring Harbor Laboratory
Published: 2000-08-01
Volume: 14
Issue: 15
Pages: 1837-1851
ISSN: 0890-9369 (ISSN-L)
1549-5477
DOI: 10.1101/gad.14.15.1837
OpenAlex: W2239090104
Cited by: 3,183
References: 190
Citations by year: 2026: 6 · 2025: 12 · 2024: 25 · 2023: 43 · 2022: 39 · 2021: 46 · 2020: 56 · 2019: 67 · 2018: 71 · 2017: 86 · 2016: 110 · 2015: 144 · 2014: 138 · 2013: 147 · 2012: 174
Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Genes & Development (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
Keywords: Wnt signaling, β-catenin, cancer, oncogenic transformation, transcriptional activation, gene expression profiles, experimental tumor model
MeSH terms: Dishevelled Proteins, Animals, Cytoskeletal Proteins, Humans, Neoplasms, Phosphoprotein Phosphatases, Phosphoproteins, Proto-Oncogene Proteins, Transcription Factors, Signal Transduction, Trans-Activators, Calcium-Calmodulin-Dependent Protein Kinases, Adenomatous Polyposis Coli Protein, Zebrafish Proteins, Glycogen Synthase Kinase 3, Adaptor Proteins, Signal Transducing, Wnt Proteins, beta Catenin

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