The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
Genetics and biology of pancreatic ductal adenocarcinoma
Open accessAbstract
Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer death in the United States with a median survival of <6 mo and a dismal 5-yr survival rate of 3%–5%. The cancer’s lethal nature stems from its propensity to rapidly disseminate to the lymphatic system and distant organs. This aggressive biology and resistance to conventional and targeted therapeutic agents leads to a typical clinical presentation of incurable disease at the time of diagnosis. The well-defined serial histopathologic picture and accompanying molecular profiles of PDAC and its precursor lesions have provided the framework for emerging basic and translational research. Recent advances include insights into the cancer’s cellular origins, high-resolution genomic profiles pointing to potential new therapeutic targets, and refined mouse models reflecting both the genetics and histopathologic evolution of human PDAC. This confluence of developments offers the opportunity for accelerated discovery and the future promise of improved treatment.
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Cites
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Cited by
Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer
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EMT and Dissemination Precede Pancreatic Tumor Formation
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Self-citationOncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism
Ying, H., Kimmelman, A. C., Lyssiotis, C. A., Hua, S., Chu, G. C., Fletcher-Sananikone, E., Locasale, J. W., Son, J., Zhang, H., Coloff, J. L., et al. (2012) · Cell · doi:10.1016/j.cell.2012.01.058 · Cited by 2,043
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Pancreatic cancers require autophagy for tumor growth
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Metadata
- Authors
- Hezel, A. F., Kimmelman, A. C., Stanger, B. Z., Bardeesy, N., & DePinho, R. A.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2006-05-15
- Volume
- 20
- Issue
- 10
- Pages
- 1218-1249
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2099023480
- Cited by
- 1,577
- References
- 60
- Type
- posted content
- Language
- en
- Open access
- diamond
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- CoChat. (2026). Citation check: Genetics and biology of pancreatic ductal adenocarcinoma. https://app.cochat.ai/papers/10.1101/gad.1415606
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- Hezel, A. F., Kimmelman, A. C., Stanger, B. Z., Bardeesy, N., & DePinho, R. A. (2006). Genetics and biology of pancreatic ductal adenocarcinoma. Genes & Development. https://doi.org/10.1101/gad.1415606
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
