PreprintCited by 165Adipose Tissue and MetabolismPeroxisome Proliferator-Activated ReceptorsAdipokines, Inflammation, and Metabolic Diseases

The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.

Molecular determinants of brown adipocyte formation and function: Figure 1.

Open access

Farmer, Stephen R.·2008·Genes & Development

DOI 10.1101/gad.1681308PMC PMC2732411

Open this paper in CoChat — free account Open PDF

Abstract

Humans contain essentially two types of adipose tissue: brown adipose tissue (BAT) and white adipose tissue (WAT). The function of WAT is to store fat while that of BAT is to burn fat for heat production. A potential strategy to combat obesity and its related disorders is to induce the conversion of WAT into BAT. In this issue of Genes & Development, Kajimura and colleagues (pp. 1397–1409) have identified a mechanism by which PRDM16, the principal regulator of brown adipocyte formation and function, can simultaneously induce BAT gene expression, while suppressing WAT gene expression. The studies suggest that PRDM16 and its associated coregulators PPARγ coactivator-1α (PGC-1α) and C-terminal-binding protein 1/2 (CtBP1/2), which control the switch from WAT to BAT, are potential targets for development of obesity-related therapeutics.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1101/gad.1681308

Cites

47 of 47 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

RETRACTED: Metabolic regulation of SIRT1 transcription via a HIC1:CtBP corepressor complex
Zhang, Q., Wang, S.-Y., Fleuriel, C., Leprince, D., Rocheleau, J. V., Piston, D. W., & Goodman, R. H. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610590104 · Cited by 171
Retracted
Prevalence of Overweight and Obesity in the United States, 1999-2004
Ogden, C. L., Carroll, M. D., Curtin, L. R., McDowell, M. A., Tabak, C. J., & Flegal, K. M. (2006) · JAMA · doi:10.1001/jama.295.13.1549 · Cited by 8,720
Brown Adipose Tissue: Function and Physiological Significance
CANNON, B., & NEDERGAARD, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00015.2003 · Cited by 6,433
The hormone resistin links obesity to diabetes
Steppan, C. M., Bailey, S. T., Bhat, S., Brown, E. J., Banerjee, R. R., Wright, C. M., Patel, H. R., Ahima, R. S., & Lazar, M. A. (2001) · Nature · doi:10.1038/35053000 · Cited by 4,755
Prevalence of Overweight and Obesity in the United States
Crespo, C. J., & Smit, E. (2003) · Human Kinetics eBooks · doi:10.5040/9781718206601.ch-001 · Cited by 4,382
Resveratrol improves health and survival of mice on a high-calorie diet
Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290
Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α
Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.11.013 · Cited by 4,057
A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis
Puigserver, P., Wu, Z., Park, C. W., Graves, R., Wright, M., & Spiegelman, B. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81410-5 · Cited by 3,864
Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
Rodgers, J. T., Lerin, C., Haas, W., Gygi, S. P., Spiegelman, B. M., & Puigserver, P. (2005) · Nature · doi:10.1038/nature03354 · Cited by 3,160
Adipocyte differentiation from the inside out
Rosen, E. D., & MacDougald, O. A. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2066 · Cited by 2,607

Flagged first, then by citations

Show all 47 references

Research works printed but not linked: 1

10.1172/JCI200421752 · DOI · Paper page

Sorted by citations

Items 101–164 of 164

The thermogenic circuit: Regulators of thermogenic competency and differentiation
Lynes, M. D., & Tseng, Y. (2015) · Genes & Diseases · doi:10.1016/j.gendis.2015.03.001 · Cited by 18
The transcriptional modulator Ifrd1 controls PGC ‐1α expression under short‐term adrenergic stimulation in brown adipocytes
Park, G., Horie, T., Kanayama, T., Fukasawa, K., Iezaki, T., Onishi, Y., Ozaki, K., Nakamura, Y., Yoneda, Y., Takarada, T., et al. (2017) · FEBS Journal · doi:10.1111/febs.14019 · Cited by 17
BMI-associated gene variants in FTO and cardiometabolic and brain disease: obesity or pleiotropy?
Ganeff, I. M. M., Bos, M. M., van Heemst, D., & Noordam, R. (2019) · Physiological Genomics · doi:10.1152/physiolgenomics.00040.2019 · Cited by 16
Sequence Analysis of theUCP1Gene in a Severe Obese Population from Southern Italy
Labruna, G., Pasanisi, F., Fortunato, G., Nardelli, C., Finelli, C., Farinaro, E., Contaldo, F., & Sacchetti, L. (2011) · Journal of Obesity · doi:10.1155/2011/269043 · Cited by 16
Intricate Transcriptional Networks of Classical Brown and Beige Fat Cells
Park, J. H., Hur, W., & Lee, S. B. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00124 · Cited by 16
1-Benzyl-4-phenyl-1H-1,2,3-triazoles improve the transcriptional functions of estrogen-related receptor γ and promote the browning of white adipose
Xu, S., Mao, L., Ding, P., Zhuang, X., Zhou, Y., Yu, L., Liu, Y., Nie, T., Xu, T., Xu, Y., et al. (2015) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2015.03.082 · Cited by 15
Subconjunctival hibernoma in a dog
Stuckey, J. A., Rankin, A. J., Romkes, G., Slack, J., Kiupel, M., & Dubielzig, R. R. (2013) · Veterinary Ophthalmology · doi:10.1111/vop.12124 · Cited by 14
Promoting Adipose Specificity: The Adiponectin Promoter
Chakrabarti, P. (2010) · Endocrinology · doi:10.1210/en.2010-0316 · Cited by 14
Effects of caloric restriction on the expression of lipocalin-2 and its receptor in the brown adipose tissue of high-fat diet-fed mice
Park, K.-A., Jin, Z. H., An, H. S., Lee, J. Y., Jeong, E. A., Choi, E. B., Kim, K. E., Shin, H. J., Lee, J. E., & Roh, G. S. (2019) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2019.23.5.335 · Cited by 12
SOX4 facilitates brown fat development and maintenance through EBF2-mediated thermogenic gene program in mice
Wang, S., He, T., Luo, Y., Ren, K., Shen, H., Hou, L., Wei, Y., Fu, T., Wenlong, X., Wang, P., et al. (2024) · Cell Death and Differentiation · doi:10.1038/s41418-024-01397-0 · Cited by 11
Development of CIDEA reporter mouse model and its application for screening thermogenic drugs
Son, Y., Choi, C., Song, C. O., Im, H., Cho, Y. K., Son, J. S., Joo, S., Joh, Y., Lee, Y. J., Seong, J. K., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-97959-0 · Cited by 11
Association of genetic variations of PRDM16 with metabolic syndrome in a general Xinjiang Uygur population
Zhang, J. H., Li, N. F., Yan, Z. T., Zhang, D. L., Wang, H. M., Guo, Y. Y., & Ling, Z. (2012) · Endocrine · doi:10.1007/s12020-011-9547-1 · Cited by 11
LDB1 Regulates Energy Homeostasis During Diet-Induced Obesity
Loyd, C., Liu, Y., Kim, T., Holleman, C. L., Galloway, J., Bethea, M. M., Ediger, B. N., Swain, T. A., Tang, Y., Stoffers, D. A., et al. (2016) · Endocrinology · doi:10.1210/en.2016-1791 · Cited by 11
Homeostatic non-shivering thermogenesis in humans facts and hypotheses
Сонькин, В. Д., Kirdin, A. A., Андреев, Р. С., & Akimov, E. B. (2010) · Human Physiology · doi:10.1134/s0362119710050129 · Cited by 10
Nuclear factor-κB is a common upstream signal for growth differentiation factor-5 expression in brown adipocytes exposed to pro-inflammatory cytokines and palmitate
Hinoi, E., Iezaki, T., Ozaki, K., & Yoneda, Y. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.09.022 · Cited by 10
RACK1 is required for adipogenesis
Kong, Q., Gao, L., Niu, Y., Gongpan, P., Xu, Y., Li, Y., & Xiong, W. (2016) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00224.2016 · Cited by 10
Angiotensin II Inhibits Adipogenic Differentiation and Promotes Mature Adipocyte Browning through the Corepressor CtBP1
Liang, X., Sun, J., Guan, H., Zhu, Q., & Yao, W. (2022) · Biomedicines · doi:10.3390/biomedicines10123131 · Cited by 9
Long Non-Coding RNAs in Brown Adipose Tissue
Lai, S., Du, K., Shi, Y., Cao, L., Wang, G., Hu, S., Jia, X., Wang, J., & Chen, S. (2020) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s264830 · Cited by 9
Chromatin remodeling protein SMAR1 regulates adipogenesis by modulating the expression of PPARγ
Pant, R., Alam, A., Choksi, A., Shah, V. K., Firmal, P., & Chattopadhyay, S. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2021.159045 · Cited by 8
Inhibitory Effects of Vanadium-Binding Proteins Purified from the Sea Squirt Halocynthia roretzi on Adipogenesis in 3T3-L1 Adipocytes
Gunasinghe, M. A., Kim, A. T., & Kim, S. M. (2019) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-019-02982-7 · Cited by 8
Identification of key adipogenic transcription factors for the pork belly parameters via the association weight matrix
Lee, S.-H., Lee, S.-H., Park, H.-B., & Kim, J. (2022) · Meat Science · doi:10.1016/j.meatsci.2022.109015 · Cited by 7
Comparative Proteomic Analysis of tPVAT during Ang II Infusion
Liang, X., Guan, H., Sun, J., Qi, Y., & Yao, W. (2021) · Biomedicines · doi:10.3390/biomedicines9121820 · Cited by 7
Functional Characterization of Preadipocytes Derived from Human Periaortic Adipose Tissue
Vargas, D., Camacho, J., Duque, J., Carreño, M., Acero-Mondragón, E. J., Pérez, M. D., Ramírez, S. O., Umana-Pizano, J. B., Obando, C., Guerrero, A. F., et al. (2017) · International Journal of Endocrinology · doi:10.1155/2017/2945012 · Cited by 6
MiR-144 regulates adipogenesis by mediating formation of C/EBPα-FOXO1 protein complex
Lin, W., Wen, X., Li, X., Chen, L., Wei, W., Zhang, L., & Chen, J. (2022) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2022.04.093 · Cited by 6
The Role of the AGPAT2 Gene in Adipose Tissue Biology and Congenital Generalized Lipodystrophy Pathophysiology
de Melo, M. E. C., da Silva, L. M. G., Cavalcante, A. C. C., Lima, J. G., & Campos, J. T. A. D. M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26115416 · Cited by 5
Efeito da redução de ninhada sobre as respostas autonômicas e metabólicas de ratos Wistar
Rinaldi, W., Ribeiro, T. A., MINCACHE, A. S. M., Fabricio, G. S., Tófolo, L. P., Gomes, R. M., Mendes, F. C. V., & Mathias, P. C. D. F. (2012) · Revista de Nutrição · doi:10.1590/s1415-52732012000300002 · Cited by 5
Antibiotics administration alleviates the high fat diet‐induced obesity through altering the lipid metabolism in young mice
Luo, S., Zhang, H., Jiang, X., Xia, Y., Tang, S., Duan, X., Sun, W. Y., Gao, M., Chen, C., Zou, Z., et al. (2022) · Lipids · doi:10.1002/lipd.12361 · Cited by 5
Les progéniteurs adipeux blancs et bruns
Bouloumié, A., Sengenès, C., & Galitzky, J. (2009) · médecine/sciences · doi:10.1051/medsci/2009252123 · Cited by 5
Sequence variants in the bovine PRDM16 gene associated with body weight in Chinese cattle breeds
Wang, J., Wang, C., Tian, R., Huang, Y.-Z., Lai, X.-S., Lan, X., Wang, J.-Q., & Chen, H. (2012) · Genetics and Molecular Research · doi:10.4238/2012.march.22.5 · Cited by 5
Effect of Acupoint Embedding on Serum Leptin and Hypothalamus Leptin Receptor Expression in Rats with Simple Obesity
Yang, Q., Xing, L., Dong, Q., Chen, H., Xia, C., Yue, X., Wang, Y., Li, L., Luo, Y., Lai, M., et al. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/3500409 · Cited by 5
Calorie hoarding and thrifting: Foxa3 finds a way
Ma, X., Xu, L., & Mueller, E. (2015) · Adipocyte · doi:10.1080/21623945.2015.1028700 · Cited by 5
Multi-omics analysis of thermogenic lipolysis in brown adipocytes
Mattanovich, M., Anagho, H. A., Argemi‐Muntadas, L., Nielsen, M. L., Gao, Q., & Möritz, T. (2025) · iScience · doi:10.1016/j.isci.2025.113382 · Cited by 5
Effects of maternal undernutrition during late pregnancy on the regulatory factors involved in growth and development in ovine fetal perirenal brown adipose tissue
Yang, H., Ma, C., Zi, Y., Zhang, M., Liu, Y., Wu, K., & Gao, F. (2021) · Animal Bioscience · doi:10.5713/ab.21.0199 · Cited by 4
Transcriptome analysis of norepinephrine-induced lipolysis in differentiated adipocytes of Bama pig
Li, H., Li, H., Zhang, J., Zhang, J., Zhang, G., Tong, X., Zhang, T., Wu, Y., Li, M., & Jin, L. G. (2023) · Gene · doi:10.1016/j.gene.2023.147753 · Cited by 4
Recent advances in brown adipose tissue biology
Shen, Y., Liu, X., Dong, M., Lin, J., Zhao, Q., Lee, H.-J., & Jin, W. (2014) · Chinese Science Bulletin · doi:10.1007/s11434-014-0386-3 · Cited by 4
Obesity and metabolic syndrome: Future therapeutics based on novel molecular pathways
Gutiérrez-Salmeán, G., Ceballos, G. M., & Ramírez‐Sánchez, I. (2012) · Clínica e Investigación en Arteriosclerosis · doi:10.1016/j.arteri.2011.11.002 · Cited by 4
Regulatory Factors that Reveal Three Distinct Adipocytes : The Brown, the White and the Brite
Waldén, T. B. (2010) · KTH Publication Database DiVA (KTH Royal Institute of Technology) · Cited by 4
The importance of thiamine availability in the thermogenic competency of human adipocytes
Vinnai, B. Á., Arianti, R., Fischer‐Posovszky, P., Wabitsch, M., Fésüs, L., & Kristóf, E. (2025) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2025.112483 · Cited by 3
Reproductive and endocrine effects of artemisinin, piperaquine, and artemisinin-piperaquine combination in rats
Li, X., Yuan, Y., Chen, Y.-Y., Li, R., Yuan, Z., Xu, Z., Xu, Q., Song, J., Li, G., & Deng, C. (2022) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-022-03739-2 · Cited by 3
Resveratrol as Anti-Obesity and Anticancer Agent
Gupta, V. K., Sonker, P., & Kumar, A. (2021) · Springer eBooks · doi:10.1007/978-981-16-1846-8_10 · Cited by 3
Anti-inflammatory, anti-lipogenesis, and anti-obesity benefits of fermented Aronia vinegar evaluated in 3T3-L1 cells and high-fat diet induced C57BL/6 mice
Lim, J., Yoo, Y.-J., Lee, S.-H., Jang, T.-H., Kamala‐Kannan, S., Lee, E.-Y., Tae, H., Yim, E.-J., Jeong, D., & Oh, B. (2022) · Food Biotechnology · doi:10.1080/08905436.2022.2124263 · Cited by 3
Whole-Genome Pathway Analysis on 132,497 Individuals Identifies Novel Gene-Sets Associated with Body Mass Index
Simonson, M. A., McQueen, M. B., & Keller, M. C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0078546 · Cited by 3
Studies on the degeneration and regeneration of the intervertebral disc
Hoogendoorn, R. J. W. (2009) · Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) · Cited by 3
Antidiabetic Properties of Bidens pilosa and Its Polyacetylenic Compounds for Management of Diabetes: Systematic Review
Waititu, K., Mugo, C. W., Nyawira, D. N., & Mwethera, P. G. (2024) · Journal of Biosciences and Medicines · doi:10.4236/jbm.2024.122013 · Cited by 2
A Novel Herbal Combination Decreased Lipid Droplets Accumulation and Cytokines Levels During Adipogenesis by Regulating Leptin, PPARγ and SREBP1c Genes Expression in 3T3L1 Cells
Gorantla, V. R., Bolla, S. R., Tuladhar, S., Bishir, M., & Mahalakshmi, A. M. (2021) · International journal of Nutrition Pharmacology Neurological Diseases · doi:10.4103/ijnpnd.ijnpnd_88_20 · Cited by 2
In Vivo evaluation of adipogenic induction in fibrous and honeycomb-structured atelocollagen scaffolds
Rodríguez, A. P., Felice, B., Sánchez, M. A., Tsujigiwa, H., Felice, C. J., & Nagatsuka, H. (2016) · Materials Science and Engineering C · doi:10.1016/j.msec.2016.02.055 · Cited by 2
Brown Fat and Its Thermoregulatory Role in the Human Neonate
Dv, M., Muralidhara, K. D., & Zubaidi, A. L. A. (2010) · Journal of Physiological and Biomedical Sciences · Cited by 2
Porcine transient receptor potential channel 1 promotes adipogenesis and lipid deposition
Fu, Y., Hao, X., Nie, J., Shang, P., Dong, X., Zhang, B., Yan, D., & Zhang, H. (2024) · Journal of Lipid Research · doi:10.1016/j.jlr.2024.100718 · Cited by 1
Physical exercise and irisin: managing obesity and related comorbidities
Negroiu, C. E., Tudorașcu, I., Dănoiu, S., Pădureanu, V., Godeanu, S., Dănoiu, R., Ungureanu, A., Beznă, M. C., & Moise, C. G. (2025) · Romanian Journal of Morphology and Embryology · doi:10.47162/rjme.66.2.05 · Cited by 1
Amplification of PRDM16, BMP7, PPARα, COX II and PGC-1α Genes Tupaia belangeri
章, 迪. (2014) · Bioprocess · doi:10.12677/bp.2014.43007
Implication de LRP1 dans l’athérosclérose et la calcification vasculaire
Woldt, E. (2009) · OpenGrey (Institut de l'Information Scientifique et Technique)
The role of the farnesoid X receptor in metabolic control
Stroeve, J. H. M. (2011) · University of Groningen research database (University of Groningen / Centre for Information Technology)
Origine développementale des adipocytes
Billon, N., & Dani, C. (2009) · Obésité · doi:10.1007/s11690-009-0216-y · Cited by 1
Supplementary material to: IMPRINTING GENES ASSOCIATED WITH ENDOMETRIOSIS
Kobayashi, H. (2014)
Development of tissue-inspired scaffolds : integrating biology with materials science
Luo, B. (2015) · DR-NTU (Nanyang Technological University) · doi:10.32657/10356/62517
A Role of Visceral Adipose and Gastric Tissue in Inflammatory Conditions Associated With Metabolic Syndrome
Mehta, R. (2013) · doi:10.13021/mars/7304
Brown Adipose Tissue Differentiation and Control Mechanism
张, 麟. (2011) · Bioprocess · doi:10.12677/bp.2011.12004
25 Hydroxycholesterol inhibits adipogenesis and expression of adipogenic transcripts in C3H10T1/2 mouse stem cells independent of hedgehog signalling mechanism
Moseti, D. (2015) · Mspace (University of Manitoba)
DPP-IV and FAS inhibitory peptides: therapeutic alternative against diabesity
León‐Galván, M. F., & Medina-Rojas, D. S. (2025) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-025-01613-9
Epigenetic Approaches to Adipose Biology
Rosen, E. D. (2010) · Research and perspectives in endocrine interactions · doi:10.1007/978-3-642-13517-0_10
VEGFR-dependent signaling contributes to postnatal brown adipose tissue development in Syrian hamsters
Sujan, K. M., Tamakoshi, Y., Seok, B. S., Yang, Z., Xu, S., Elfeky, M., Kato-Suzuki, M., & Okamatsu‐Ogura, Y. (2026) · The Journal of Physiological Sciences · doi:10.1016/j.jphyss.2026.100106
BindingDB Entry 50046071: 1-Benzyl-4-phenyl-1H-1,2,3-triazoles improve the transcriptional functions of estrogen-related receptor¿ and promote the browning of white adipose.
BindingDB (2016) · UC San Diego · doi:10.7270/q2222wjm
Role of caveolin-1 in brown adipose tissue
Mattsson, C. L. (2010) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
Molecular signatures of brown, white and brite adipose tissues.
Waldén, T. B., Hansen, I. R., Timmons, J. A., Cannon, B., & Nedergaard, J. (2010) · DiVA (Stockholm University)

Authors: Farmer, S. R.
Affiliations: Boston University (US)
Corresponding author: Farmer, Stephen R.
ORCID: Farmer, Stephen R.
Venue: Genes & Development
Publisher: Cold Spring Harbor Laboratory
Published: 2008-05-15
Volume: 22
Issue: 10
Pages: 1269-1275
ISSN: 0890-9369 (ISSN-L)
1549-5477
DOI: 10.1101/gad.1681308
PMC: PMC2732411
OpenAlex: W2118369587
Cited by: 165
References: 47
Citations by year: 2026: 1 · 2025: 5 · 2024: 3 · 2023: 1 · 2022: 9 · 2021: 7 · 2020: 6 · 2019: 6 · 2018: 7 · 2017: 8 · 2016: 11 · 2015: 11 · 2014: 14 · 2013: 19 · 2012: 11
Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Genes & Development (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HighWire Press Open Archive (submittedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: brown adipose tissue, brown adipocyte differentiation, white adipose tissue, PRDM16, PGC-1α, obesity, thermogenesis, adipose tissue gene expression, transcriptional coactivator
MeSH terms: Animals, Cell Differentiation, DNA-Binding Proteins, Humans, Models, Biological, Obesity, Phenotype, Repressor Proteins, Transcription Factors, Neovascularization, Physiologic, Thiazolidinediones, PPAR gamma, Adipose Tissue, White, Adipocytes, Brown

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Molecular determinants of brown adipocyte formation and function: Figure 1.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks