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Molecular determinants of brown adipocyte formation and function: Figure 1.
Open accessAbstract
Humans contain essentially two types of adipose tissue: brown adipose tissue (BAT) and white adipose tissue (WAT). The function of WAT is to store fat while that of BAT is to burn fat for heat production. A potential strategy to combat obesity and its related disorders is to induce the conversion of WAT into BAT. In this issue of Genes & Development, Kajimura and colleagues (pp. 1397–1409) have identified a mechanism by which PRDM16, the principal regulator of brown adipocyte formation and function, can simultaneously induce BAT gene expression, while suppressing WAT gene expression. The studies suggest that PRDM16 and its associated coregulators PPARγ coactivator-1α (PGC-1α) and C-terminal-binding protein 1/2 (CtBP1/2), which control the switch from WAT to BAT, are potential targets for development of obesity-related therapeutics.
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“At the molecular level, brown fat differentiation involves mechanisms common to both brown and white adipocyte differentiation, as well as some specific factors 89,165–167.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [167]
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Metadata
- Authors
- Farmer, S. R.
- Affiliations
- Boston University (US)
- Corresponding author
- Farmer, Stephen R.
- ORCID
- Farmer, Stephen R.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2008-05-15
- Volume
- 22
- Issue
- 10
- Pages
- 1269-1275
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- PMC
- PMC2732411
- OpenAlex
- W2118369587
- Cited by
- 165
- References
- 47
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 3 · 2023: 1 · 2022: 9 · 2021: 7 · 2020: 6 · 2019: 6 · 2018: 7 · 2017: 8 · 2016: 11 · 2015: 11 · 2014: 14 · 2013: 19 · 2012: 11
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- brown adipose tissue, brown adipocyte differentiation, white adipose tissue, PRDM16, PGC-1α, obesity, thermogenesis, adipose tissue gene expression, transcriptional coactivator
- MeSH terms
- Animals, Cell Differentiation, DNA-Binding Proteins, Humans, Models, Biological, Obesity, Phenotype, Repressor Proteins, Transcription Factors, Neovascularization, Physiologic, Thiazolidinediones, PPAR gamma, Adipose Tissue, White, Adipocytes, Brown
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