The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Selective stabilization of mammalian microRNAs by 3′ adenylation mediated by the cytoplasmic poly(A) polymerase GLD-2
Open accessAbstract
The steady-state levels of microRNAs (miRNAs) and their activities are regulated by the post-transcriptional processes. It is known that 3′ ends of several miRNAs undergo post-dicing adenylation or uridylation. We isolated the liver-specific miR-122 from human hepatocytes and mouse livers. Direct analysis by mass spectrometry revealed that one variant of miR-122 has a 3′-terminal adenosine that is introduced after processing by Dicer. We identified GLD-2, which is a regulatory cytoplasmic poly(A) polymerase, as responsible for the 3′-terminal adenylation of miR-122 after unwinding of the miR-122/miR-122* duplex. In livers from GLD-2-null mice, the steady-state level of the mature form of miR-122 was specifically lower than in heterozygous mice, whereas no reduction of pre-miR-122 was observed, demonstrating that 3′-terminal adenylation by GLD-2 is required for the selective stabilization of miR-122 in the liver.
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1 retracted
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Metadata
- Authors
- Katoh, T., Sakaguchi, Y., Miyauchi, K., Suzuki, T., Kashiwabara, S.-I., Baba, T., & Suzuki, T.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2009-02-15
- Volume
- 23
- Issue
- 4
- Pages
- 433-438
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2072636314
- Cited by
- 440
- References
- 47
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Katoh, T., Sakaguchi, Y., Miyauchi, K., Suzuki, T., Kashiwabara, S.-I., Baba, T., & Suzuki, T. (2009). Selective stabilization of mammalian microRNAs by 3′ adenylation mediated by the cytoplasmic poly(A) polymerase GLD-2. Genes & Development. https://doi.org/10.1101/gad.1761509
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