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KDM7 is a dual demethylase for histone H3 Lys 9 and Lys 27 and functions in brain development
Open accessAbstract
Methylation of histone H3 Lys 9 and Lys 27 (H3K9 and H3K27) is associated with transcriptional silencing. Here we show that KDM7, a JmjC domain-containing protein, catalyzes demethylation of both mono- or dimethylated H3K9 and H3K27. Inhibition of KDM7 orthologs in zebrafish resulted in developmental brain defects. KDM7 interacts with the follistatin gene locus, and KDM7 depletion in mammalian neuronal cells suppressed follistatin gene transcription in association with increased levels of dimethylated H3K9 and H3K27. Our findings identify KDM7 as a dual demethylase for H3K9 and H3K27 that functions as an eraser of silencing marks on chromatin during brain development.
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“KDM7A (encoding Lysine Demethylase 7A), which plays a central role in the nervous system and midbrain development (Horton et al., 2010; Qi et al., 2010; Tsukada et al., 2010).”
From Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders (2019) · cites this paper as Tsukada et al., 2010
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Metadata
- Authors
- Tsukada, Y.-I., Ishitani, T., & Nakayama, K. I.
- Affiliations
- Kyushu University (JP)
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2010-03-01
- Volume
- 24
- Issue
- 5
- Pages
- 432-437
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- PMC
- PMC2827838
- OpenAlex
- W2116387269
- Cited by
- 158
- References
- 25
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 7 · 2023: 15 · 2022: 6 · 2021: 15 · 2020: 7 · 2019: 11 · 2018: 7 · 2017: 11 · 2016: 5 · 2015: 14 · 2014: 16 · 2013: 3 · 2012: 13
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer-related gene regulation
- Keywords
- histone demethylase, H3K9 demethylation, H3K27 demethylation, JmjC domain, brain development, transcriptional silencing, follistatin, zebrafish, neurons, histone methylation
- MeSH terms
- Animals, Brain, Cells, Cultured, Embryo, Nonmammalian, Histones, Neurons, Zebrafish, Gene Expression Regulation, Developmental, Zebrafish Proteins, Follistatin, Mice, Jumonji Domain-Containing Histone Demethylases
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