The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Structural basis of YAP recognition by TEAD4 in the Hippo pathway
Open accessAbstract
The Hippo signaling pathway controls cell growth, proliferation, and apoptosis by regulating the expression of target genes that execute these processes. Acting downstream from this pathway is the YAP transcriptional coactivator, whose biological function is mediated by the conserved TEAD family transcription factors. The interaction of YAP with TEADs is critical to regulate Hippo pathway-responsive genes. Here, we describe the crystal structure of the YAP-interacting C-terminal domain of TEAD4 in complex with the TEAD-interacting N-terminal domain of YAP. The structure reveals that the N-terminal region of YAP is folded into two short helices with an extended loop containing the PXXΦP motif in between, while the C-terminal domain of TEAD4 has an immunoglobulin-like fold. YAP interacts with TEAD4 mainly through the two short helices. Point mutations of TEAD4 indicate that the residues important for YAP interaction are required for its transforming activity. Mutagenesis reveals that the PXXΦP motif of YAP, although making few contacts with TEAD4, is important for TEAD4 interaction as well as for the transforming activity.
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Cites
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“Interaction with TEADs is important for Yki/YAPdependent gene induction and growth control (Vassilev et al. 2001; Goulev et al. 2008; Wu et al. 2008; Zhang et al. 2008; Zhao et al. 2008b).”
BackgroundInfluentialThe TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control
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Cited by
The Hippo Signaling Pathway in Development and Cancer
Pan, D. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.09.011 · Cited by 2,269
YAP/TAZ at the Roots of Cancer
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Liu-Chittenden, Y., Huang, B., Shim, J. S., Chen, Q., Lee, S.-J., Anders, R. A., Liu, J. O., & Pan, D. (2012) · Genes & Development · doi:10.1101/gad.192856.112 · Cited by 1,452
The Hippo pathway: regulators and regulations.
Yu, F.-X., & Guan, K.-L. (2013) · Genes & Development · doi:10.1101/gad.210773.112 · Cited by 1,231
The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal
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Metadata
- Authors
- Chen, L., Chan, S. W., Zhang, X., Walsh, M., Lim, C. J., Hong, W., & Song, H.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2010-02-01
- Volume
- 24
- Issue
- 3
- Pages
- 290-300
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2127240308
- Cited by
- 249
- References
- 9
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Chen, L., Chan, S. W., Zhang, X., Walsh, M., Lim, C. J., Hong, W., & Song, H. (2010). Structural basis of YAP recognition by TEAD4 in the Hippo pathway. Genes & Development. https://doi.org/10.1101/gad.1865310
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