The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Structural insights into the YAP and TEAD complex
Open accessAbstract
The Yes-associated protein (YAP) transcriptional coactivator is a key regulator of organ size and a candidate human oncogene inhibited by the Hippo tumor suppressor pathway. The TEAD family of transcription factors binds directly to and mediates YAP-induced gene expression. Here we report the three-dimensional structure of the YAP (residues 50–171)–TEAD1 (residues 194–411) complex, in which YAP wraps around the globular structure of TEAD1 and forms extensive interactions via three highly conserved interfaces. Interface 3, including YAP residues 86–100, is most critical for complex formation. Our study reveals the biochemical nature of the YAP–TEAD interaction, and provides a basis for pharmacological intervention of YAP–TEAD hyperactivation in human diseases.
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Cites
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Self-citationTEAD mediates YAP-dependent gene induction and growth control
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YAP1 increases organ size and expands undifferentiated progenitor cells
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Cited by
Hornbeck, P. V., Kornhauser, J. M., Tkachev, S., Zhang, B., Skrzypek, E., Murray, B., Latham, V., & Sullivan, M. (2012) · Nucleic Acids Research · doi:10.1093/nar/gkr1122 · Cited by 1,646
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The Hippo pathway: regulators and regulations.
Yu, F.-X., & Guan, K.-L. (2013) · Genes & Development · doi:10.1101/gad.210773.112 · Cited by 1,231
Self-citationThe Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal
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Self-citationThe Hippo Signaling Pathway in Development and Disease
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Metadata
- Authors
- Li, Z., Zhao, B., Wang, P., Chen, F., Dong, Z., Yang, H., Guan, K.-L., & Xu, Y.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2010-02-01
- Volume
- 24
- Issue
- 3
- Pages
- 235-240
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2160778199
- Cited by
- 401
- References
- 39
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Li, Z., Zhao, B., Wang, P., Chen, F., Dong, Z., Yang, H., Guan, K.-L., & Xu, Y. (2010). Structural insights into the YAP and TEAD complex. Genes & Development. https://doi.org/10.1101/gad.1865810
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