The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Mutant p53: one name, many proteins
Open accessAbstract
There is now strong evidence that mutation not only abrogates p53 tumor-suppressive functions, but in some instances can also endow mutant proteins with novel activities. Such neomorphic p53 proteins are capable of dramatically altering tumor cell behavior, primarily through their interactions with other cellular proteins and regulation of cancer cell transcriptional programs. Different missense mutations in p53 may confer unique activities and thereby offer insight into the mutagenic events that drive tumor progression. Here we review mechanisms by which mutant p53 exerts its cellular effects, with a particular focus on the burgeoning mutant p53 transcriptome, and discuss the biological and clinical consequences of mutant p53 gain of function.
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Citations
Cites
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BackgroundInfluentialSenescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
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Cited by
Kastenhuber, E. R., & Lowe, S. W. (2017) · Cell · doi:10.1016/j.cell.2017.08.028 · Cited by 1,906
Mutant p53 in Cancer: New Functions and Therapeutic Opportunities
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How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression
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Targeting p53 pathways: mechanisms, structures, and advances in therapy
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Mutational processes shape the landscape of TP53 mutations in human cancer
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Metadata
- Authors
- Freed-Pastor, W. A., & Prives, C.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2012-06-15
- Volume
- 26
- Issue
- 12
- Pages
- 1268-1286
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2069452349
- Cited by
- 1,247
- References
- 30
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Freed-Pastor, W. A., & Prives, C. (2012). Mutant p53: one name, many proteins. Genes & Development. https://doi.org/10.1101/gad.190678.112
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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