The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
The role of JNK in the development of hepatocellular carcinoma
Open accessAbstract
The cJun NH 2-terminal kinase (JNK) signal transduction pathway has been implicated in the growth of carcinogen-induced hepatocellular carcinoma. However, the mechanism that accounts for JNK-regulated tumor growth is unclear. Here we demonstrate that compound deficiency of the two ubiquitously expressed JNK isoforms (JNK1 and JNK2) in hepatocytes does not prevent hepatocellular carcinoma development. Indeed, JNK deficiency in hepatocytes increased the tumor burden. In contrast, compound JNK deficiency in hepatocytes and nonparenchymal cells reduced both hepatic inflammation and tumorigenesis. These data indicate that JNK plays a dual role in the development of hepatocellular carcinoma. JNK promotes an inflammatory hepatic environment that supports tumor development, but also functions in hepatocytes to reduce tumor development.
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Park, E. J., Lee, J. H., Yu, G.-Y., He, G., Ali, S. R., Holzer, R. G., Österreicher, C. H., Takahashi, H., & Karin, M. (2010) · Cell · doi:10.1016/j.cell.2009.12.052 · Cited by 1,764
Requirement of JNK for Stress- Induced Activation of the Cytochrome c-Mediated Death Pathway
Tournier, C., Hess, P., Yang, D. D., Xu, J., Turner, T. K., Nimnual, A., Bar-Sagi, D., Jones, S. N., Flavell, R. A., & Davis, R. J. (2000) · Science · doi:10.1126/science.288.5467.870 · Cited by 1,728
Self-citationLiver Failure and Defective Hepatocyte Regeneration in Interleukin-6-Deficient Mice
Cressman, D. E., Greenbaum, L. E., DeAngelis, R. A., Ciliberto, G., Furth, E. E., Poli, V., & Taub, R. (1996) · Science · doi:10.1126/science.274.5291.1379 · Cited by 1,538
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Sakurai, T., He, G., Matsuzawa, A., Yu, G.-Y., Maeda, S., Hardiman, G., & Karin, M. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.06.016 · Cited by 487
Mikkola, H. K. A., Klintman, J., Yang, H., Hock, H., Schlaeger, T. M., Fujiwara, Y., & Orkin, S. H. (2003) · Nature · doi:10.1038/nature01345 · Cited by 371
c-Jun/AP-1 controls liver regeneration by repressing p53/p21 and p38 MAPK activity
Stepniak, E., Ricci, R., Eferl, R., Sumara, G., Sumara, I., Rath, M., Hui, L., & Wagner, E. F. (2006) · Genes & Development · doi:10.1101/gad.390506 · Cited by 232
Cited by
Kern, L., Mittenbühler, M., Vesting, A., Ostermann, A., Wunderlich, C., & Wunderlich, F. (2018) · Cancers · doi:10.3390/cancers11010024 · Cited by 331
Nakagawa, H., Hirata, Y., Takeda, K., Hayakawa, Y., Sato, T., Kinoshita, H., Sakamoto, K., Nakata, W., Hikiba, Y., Omata, M., et al. (2011) · Hepatology · doi:10.1002/hep.24357 · Cited by 86
BRAF inhibitors suppress apoptosis through off-target inhibition of JNK signaling
Vin, H., Ojeda, S. S., Ching, G., Leung, M. L., Chitsazzadeh, V., Dwyer, D. W., Adelmann, C. H., Restrepo, M., Richards, K. N., Stewart, L. R., et al. (2013) · eLife · doi:10.7554/elife.00969 · Cited by 84
Sirtuins at the Service of Healthy Longevity
Watroba, M., & Szukiewicz, D. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.724506 · Cited by 64
JNK pathway in osteosarcoma: pathogenesis and therapeutics
Li, Y.-S., Deng, Z.-H., Zeng, C., & Lei, G.-H. (2016) · Journal of Receptors and Signal Transduction · doi:10.3109/10799893.2015.1122045 · Cited by 31
Metadata
- Authors
- Das, M., Garlick, D. S., Greiner, D. L., & Davis, R. J.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2011-03-15
- Volume
- 25
- Issue
- 6
- Pages
- 634-645
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2162297313
- Cited by
- 186
- References
- 7
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Das, M., Garlick, D. S., Greiner, D. L., & Davis, R. J. (2011). The role of JNK in the development of hepatocellular carcinoma. Genes & Development. https://doi.org/10.1101/gad.1989311
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
