Cited by 152Genomics and Chromatin DynamicsNF-κB Signaling PathwaysImmune Response and Inflammation

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The genomic landscapes of inflammation

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Natoli, Gioacchino, Ghisletti, Serena, Barozzi, Iros·2011·Genes & Development

DOI 10.1101/gad.2018811PMC PMC3022255

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Abstract

Inflammation involves the activation of a highly coordinated gene expression program that is specific for the initial stimulus and occurs in a different manner in bystander parenchymal cells and professional immune system cells recruited to the inflamed site. Recent data demonstrate that developmental transcription factors like the macrophage fate-determining Pu.1 set the stage for the activity of ubiquitous transcription factors activated by inflammatory stimuli, like NF-kB, AP-1, and interferon regulatory factors (IRFs). The intersection of lineage-determining and stimulus-activated transcription factors at enhancers explains cell type specificity in inflammatory responses.

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Authors: Natoli, G., Ghisletti, S., & Barozzi, I.
Affiliations: European Institute of Oncology (IT)
ORCID: Natoli, Gioacchino
Ghisletti, Serena
Barozzi, Iros
Venue: Genes & Development
Publisher: Cold Spring Harbor Laboratory
Published: 2011-01-15
Volume: 25
Issue: 2
Pages: 101-106
ISSN: 0890-9369 (ISSN-L)
1549-5477
DOI: 10.1101/gad.2018811
PMC: PMC3022255
OpenAlex: W2005656449
Cited by: 152
References: 37
Citations by year: 2025: 6 · 2024: 3 · 2023: 11 · 2022: 7 · 2021: 10 · 2020: 8 · 2019: 7 · 2018: 11 · 2017: 10 · 2016: 9 · 2015: 14 · 2014: 19 · 2013: 15 · 2012: 10
Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Genes & Development (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
Funders: Associazione Italiana per la Ricerca sul Cancro
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: inflammation, transcriptional programs, transcription factors, enhancers, PU.1, macrophage differentiation, NF-kB, AP-1, interferon regulatory factors, cell type specificity
MeSH terms: Animals, Gene Expression Regulation, Humans, Inflammation, Macrophages, Transcription Factors, Genome

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