DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly
Open accessAbstract
In the absence of growth signals, cells exit the cell cycle and enter into G0 or quiescence. Alternatively, cells enter senescence in response to inappropriate growth signals such as oncogene expression. The molecular mechanisms required for cell cycle exit into quiescence or senescence are poorly understood. The DREAM (DP, RB [retinoblastoma], E2F, and MuvB) complex represses cell cycle-dependent genes during quiescence. DREAM contains p130, E2F4, DP1, and a stable core complex of five MuvB-like proteins: LIN9, LIN37, LIN52, LIN54, and RBBP4. In mammalian cells, the MuvB core dissociates from p130 upon entry into the cell cycle and binds to BMYB during S phase to activate the transcription of genes expressed late in the cell cycle. We used mass spectroscopic analysis to identify phosphorylation sites that regulate the switch of the MuvB core from BMYB to DREAM. Here we report that DYRK1A can specifically phosphorylate LIN52 on serine residue 28, and that this phosphorylation is required for DREAM assembly. Inhibiting DYRK1A activity or point mutation of LIN52 disrupts DREAM assembly and reduces the ability of cells to enter quiescence or undergo Ras-induced senescence. These data reveal an important role for DYRK1A in the regulation of DREAM activity and entry into quiescence.
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Dephosphorylated forms of p130 or p107 in the DREAM complex play an essential role in the induction of senescence, as well as quiescence.
“Additionally, the dephosphorylated forms of p130 or p107 in the DREAM complex (DP, RB, E2F and MuvB) play an essential role in the induction of senescence, as well as quiescence [8,9].”
From The role of cellular senescence and SASP in tumour microenvironment (2023) · cites this paper as [8]
The Abstract reports that disrupting DREAM assembly reduces cells’ ability to enter quiescence or undergo Ras-induced senescence. But the paper identifies phosphorylation of LIN52—not dephosphorylation of p130 or p107—as the modification required for DREAM assembly (Discussion; page unavailable). It therefore supports the role of DREAM in these processes, but not the claim about dephosphorylated p130 or p107. (LLM, conf=0.87)
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Cites
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., & Lowe, S. W. (1997) · Cell · doi:10.1016/s0092-8674(00)81902-9 · Cited by 5,178 · cited 2× · see citing works
“DYRK1A and intact LIN52 are both required for oncogenic Ras-induced senescence Oncogene-induced senescence is characterized by permanent cell cycle arrest in G0/G1 with induction of senescence-associated b-galactosidase (SA-b-gal) activity (Serrano et al. 1997).”
BackgroundMethodCell cycle, CDKs and cancer: a changing paradigm
Malumbres, M., & Barbacid, M. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2602 · Cited by 3,957 · cited 1× · see citing works
“Binding and inhibition of E2Fs by RB family members are relieved by CDK (cyclin-dependent kinase) protein kinases that phosphorylate all RB proteins in a cell cycle-dependent manner (Cobrinik 2005; Malumbres and Barbacid 2009).”
BackgroundWatterson, K. R., Bestow, D., Gallagher, J. R., Hamilton, D. L., Ashford, F. B., Meakin, P. J., & Ashford, M. L. J. (2012) · Neurosignals · doi:10.1159/000334144 · Cited by 3,395 · see citing works
The selectivity of protein kinase inhibitors: a further update
Bain, J., Plater, L., Elliott, M., Shpiro, N., Hastie, C. J., McLauchlan, H., Klevernic, I. V., Arthur, J. S. C., Alessi, D. R., & Cohen, P. (2007) · Biochemical Journal · doi:10.1042/bj20070797 · Cited by 2,522 · see citing works
Creation of human tumour cells with defined genetic elements
Hahn, W. C., Counter, C. M., Lundberg, A. S., Beijersbergen, R. L., Brooks, M. W., & Weinberg, R. A. (1999) · Nature · doi:10.1038/22780 · Cited by 2,345 · see citing works
To cycle or not to cycle: a critical decision in cancer
Malumbres, M., & Barbacid, M. (2001) · Nature reviews. Cancer · doi:10.1038/35106065 · Cited by 1,475 · see citing works
G1 cell-cycle control and cancer
Massagué, J. (2004) · Nature · doi:10.1038/nature03094 · Cited by 1,217 · see citing works
Senescence in tumours: evidence from mice and humans
Collado, M., & Serrano, M. (2010) · Nature Reviews Cancer · doi:10.1038/nrc2772 · Cited by 1,124 · cited 1× · see citing works
“Oncogene-induced senescence in premalignant lesions in mouse models as well as in some human tumors could serve as a protective tumor suppressor mechanism (for review, see Collado and Serrano 2010).”
BackgroundThe E2F transcriptional network: old acquaintances with new faces
Dimova, D. K., & Dyson, N. J. (2005) · Oncogene · doi:10.1038/sj.onc.1208612 · Cited by 715 · see citing works
Takahashi, Y., Rayman, J. B., & Dynlacht, B. D. (2000) · Genes & Development · doi:10.1101/gad.14.7.804 · Cited by 621 · see citing works
Pocket proteins and cell cycle control
Cobrinik, D. (2005) · Oncogene · doi:10.1038/sj.onc.1208619 · Cited by 601 · see citing works
Conserved functions of the pRB and E2F families
van den Heuvel, S., & Dyson, N. J. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2469 · Cited by 489 · see citing works
Altafaj, X. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.18.1915 · Cited by 396 · see citing works
Litovchick, L., Sadasivam, S., Florens, L., Zhu, X., Swanson, S. K., Velmurugan, S., Chen, R., Washburn, M. P., Liu, X. S., & DeCaprio, J. A. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.04.015 · Cited by 396 · see citing works
Self-citationminibrain: A new protein kinase family involved in postembryonic neurogenesis in Drosophila
Tejedor, F. J., Zhu, X., Kaltenbach, E., Ackermann, A., Baumann, A., Canal, I., Heisenberg, M., Fischbach, K. F., & Pongs, O. (1995) · Neuron · doi:10.1016/0896-6273(95)90286-4 · Cited by 379 · see citing works
Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1
Baek, K., Zaslavsky, A., Lynch, R. C., Britt, C., Okada, Y., Siarey, R. J., Lensch, M. W., Park, I., Yoon, S. S., Minami, T., et al. (2009) · Nature · doi:10.1038/nature08062 · Cited by 374 · see citing works
Woods, Y. L., Cohen, P., Becker, W. B., Jakes, R., Goedert, M., Wang, X., & Proud, C. G. (2001) · Biochemical Journal · doi:10.1042/bj3550609 · Cited by 343 · see citing works
Fotaki, V., Dierssen, M., Alcántara, S., Martı́nez, S., Martı́, E., Casas, C., Visa, J., Soriano, E., Estivill, X., & Arbonés, M. L. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.18.6636-6647.2002 · Cited by 330 · see citing works
A Common Set of Gene Regulatory Networks Links Metabolism and Growth Inhibition
Cam, H., Balciunaite, E., Blais, A., Spektor, A., Scarpulla, R. C., Young, R., Kluger, Y., & Dynlacht, B. D. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.09.037 · Cited by 322 · see citing works
Aranda, S., Laguna, A., & de la Luna, S. (2011) · The FASEB Journal · doi:10.1096/fj.10-165837 · Cited by 320 · see citing works
Rayman, J. B., Takahashi, Y., Indjeian, V. B., Dannenberg, J.-H., Catchpole, S., Watson, R. J., te Riele, H., & Dynlacht, B. D. (2002) · Genes & Development · doi:10.1101/gad.969202 · Cited by 288 · see citing works
Korenjak, M., Taylor‐Harding, B., Binné, U. K., Satterlee, J. S., Nolan-Stevaux, O., Aasland, R., White‐Cooper, H., Dyson, N. J., & Brehm, A. (2004) · Cell · doi:10.1016/j.cell.2004.09.034 · Cited by 281 · see citing works
Contestabile, A., Fila, T., Ceccarelli, C., Bonasoni, P., Bonapace, L., Santini, D., Bartesaghi, R., & Ciani, E. (2007) · Hippocampus · doi:10.1002/hipo.20308 · Cited by 281 · see citing works
Kentrup, H., Becker, W. B., Heukelbach, J., Wilmes, A., Schürmann, A., Huppertz, C., Kainulainen, H., & Joost, H. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.7.3488 · Cited by 259 · see citing works
Identification of a Drosophila Myb-E2F2/RBF transcriptional repressor complexPreprint
Lewis, P. W., Beall, E. L., Fleischer, T. C., Georlette, D., Link, A. J., & Botchan, M. R. (2004) · Genes & Development · doi:10.1101/gad.1255204 · Cited by 255 · see citing works
Proteomic Analysis by Multidimensional Protein Identification Technology
Florens, L. A., & Washburn, M. P. (2006) · Humana Press eBooks · doi:10.1385/1-59745-026-x:159 · Cited by 242 · see citing works
Self-citationSpecificity Determinants of Substrate Recognition by the Protein Kinase DYRK1A
Himpel, S., Tegge, W. J., Frank, R., Leder, S., Joost, H., & Becker, W. B. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.4.2431 · Cited by 235 · see citing works
Role for a Drosophila Myb-containing protein complex in site-specific DNA replication
Beall, E. L., Manak, J. R., Zhou, S., Bell, M., Lipsick, J. S., & Botchan, M. R. (2002) · Nature · doi:10.1038/nature01228 · Cited by 223 · see citing works
Smith, E. J., Leone, G., DeGregori, J., Jakoi, L., & Nevins, J. R. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.12.6965 · Cited by 218 · see citing works
Function and regulation of Dyrk1A: towards understanding Down syndrome
Park, J., Song, W., & Chung, K. C. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0123-2 · Cited by 205 · see citing works
LATS tumor suppressor: A new governor of cellular homeostasis
Grieve, S., & Yang, X. (2010) · Cell Cycle · doi:10.4161/cc.9.19.13386 · Cited by 203 · see citing works
Schmit, F., Korenjak, M., Mannefeld, M., Schmitt, K., Franke, C., von Eyss, B., Gagrica, S., Hanel, F., Brehm, A., & Gaubatz, S. (2007) · Cell Cycle · doi:10.4161/cc.6.15.4512 · Cited by 179 · see citing works
Kannan, N., & Neuwald, A. F. (2004) · Protein Science · doi:10.1110/ps.04637904 · Cited by 167 · see citing works
Yabut, O., Domogauer, J., & D’Arcangelo, G. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.4711-09.2010 · Cited by 154 · see citing works
Down Syndrome: From Understanding the Neurobiology to Therapy
Gardiner, K., Hérault, Y., Lott, I. T., Antonarakis, S. E., Reeves, R. H., & Dierssen, M. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3728-10.2010 · Cited by 149 · see citing works
Harrison, M. M., Ceol, C. J., Lu, X., & Horvitz, H. R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608461103 · Cited by 142 · see citing works
Georlette, D., Ahn, S., MacAlpine, D. M., Cheung, E. J., Lewis, P. W., Beall, E. L., Bell, S. P., Speed, T. P., Manak, J. R., & Botchan, M. R. (2007) · Genes & Development · doi:10.1101/gad.1600107 · Cited by 142 · see citing works
Dannenberg, J.-H., Schuijff, L., Dekker, M., van der Valk, M., & Riele, H. T. (2004) · Genes & Development · doi:10.1101/gad.322004 · Cited by 137 · see citing works
Hitting their targets: an emerging picture of E2F and cell cycle control
Blais, A., & Dynlacht, B. D. (2004) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2004.07.003 · Cited by 131 · see citing works
YakA, a protein kinase required for the transition from growth to development in Dictyostelium
Souza, G. M., Lu, S., & Kuspa, A. (1998) · Development · doi:10.1242/dev.125.12.2291 · Cited by 129 · see citing works
Molecular signature of oncogenic ras-induced senescence
Mason, D. X., Jackson, T. J., & Lin, A. W. (2004) · Oncogene · doi:10.1038/sj.onc.1208172 · Cited by 127 · see citing works
A kinase shRNA screen links LATS2 and the pRB tumor suppressorPreprint
Tschöp, K., Conery, A. R., Litovchick, L., DeCaprio, J. A., Settleman, J. E., Harlow, E., & Dyson, N. J. (2011) · Genes & Development · doi:10.1101/gad.2000211 · Cited by 125 · see citing works
Self-citationOsterloh, L., von Eyß, B., Schmit, F., Rein, L., Hübner, D., Samans, B., Hauser, S., & Gaubatz, S. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601478 · Cited by 122 · see citing works
Pilkinton, M. A., Sandoval, R., & Colamonici, O. R. (2007) · Oncogene · doi:10.1038/sj.onc.1210562 · Cited by 111 · see citing works
The SynMuv genes of Caenorhabditis elegans in vulval development and beyond
Fay, D. S., & Yochem, J. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.03.016 · Cited by 103 · see citing works
The Inhibition of Polo Kinase by Matrimony Maintains G2 Arrest in the Meiotic Cell Cycle
Xiang, Y., Takeo, S., Florens, L. A., et al. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050323 · Cited by 78 · see citing works
Self-citationSpecific In Vivo Roles for E2Fs in Differentiation and Development
McClellan, K. A., & Slack, R. S. (2007) · Cell Cycle · doi:10.4161/cc.6.23.4997 · Cited by 68 · see citing works
Inhibition of oncogenic transformation by mammalian Lin‐9, a pRB‐associated protein
Gagrica, S., Hauser, S., Kolfschoten, I., Osterloh, L., Agami, R., & Gaubatz, S. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600470 · Cited by 63 · see citing works
Interweaving the Cell Cycle Machinery with Cell Differentiation
Miller, J. P., Yeh, N., Vidal, A., & Koff, A. (2007) · Cell Cycle · doi:10.4161/cc.6.23.5042 · Cited by 62 · see citing works
Glycogen Synthase Kinase 3 Phosphorylates RBL2/p130 during Quiescence
Litovchick, L., Chestukhin, A., & DeCaprio, J. A. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.20.8970-8980.2004 · Cited by 59 · see citing works
Self-citationCell Cycle Genes Are the Evolutionarily Conserved Targets of the E2F4 Transcription Factor
Conboy, C. B., Spyrou, C., Thorne, N., Wade, E. J., Barbosa‐Morais, N. L., Wilson, M. D., Bhattacharjee, A., Young, R. A., Tavaré, S., Lees, J. A., et al. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001061 · Cited by 56 · see citing works
Mip/LIN-9 Regulates the Expression of B-Myb and the Induction of Cyclin A, Cyclin B, and CDK1
Pilkinton, M. A., Sandoval, R., Song, J., Ness, S. A., & Colamonici, O. R. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m609924200 · Cited by 55 · see citing works
Gene Network Disruptions and Neurogenesis Defects in the Adult Ts1Cje Mouse Model of Down Syndrome
Hewitt, C., Ling, K., Merson, T. D., Simpson, K., Ritchie, M. E., King, S. L., Pritchard, M. A., Smyth, G. K., Thomas, T., Scott, H. S., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011561 · Cited by 55 · see citing works
The Retinoblastoma Gene Family in Cell Cycle Regulation and Suppression of Tumorigenesis
Dannenberg, J.-H., & te Riele, H. P. J. (2006) · Results and Problems in Cell Differentiation · doi:10.1007/400_002 · Cited by 47 · see citing works
Taminato, A., Bagattini, R., Gorjão, R., et al. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.01-11-0555 · Cited by 46 · see citing works
Efficient eukaryotic expression system for authentic human sex hormone-binding globulin
Hilpert, J., Vorum, H., Burmeister, R., Spoelgen, R., Grishkovskaya, I., Misselwitz, R., Nykjær, A., & Willnow, T. E. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3600609 · Cited by 45 · see citing works
Cycling through development in Drosophila and other metazoa
Vidwans, S. J., & Su, T. T. (2001) · Nature Cell Biology · doi:10.1038/35050681 · Cited by 39 · see citing works
Widespread impairment of cell proliferation in the neonate Ts65Dn mouse, a model for Down syndrome
Contestabile, A., Fila, T., Cappellini, A., Bartesaghi, R., & Ciani, E. (2009) · Cell Proliferation · doi:10.1111/j.1365-2184.2009.00587.x · Cited by 38 · see citing works
Cell-cycle control in Caenorhabditis elegans: how the worm moves from G1 to S
Koreth, J., & van den Heuvel, S. (2005) · Oncogene · doi:10.1038/sj.onc.1208607 · Cited by 34 · see citing works
Generation and Analysis of Multidimensional Protein Identification Technology Datasets
Swanson, S. K., Florens, L. A., & Washburn, M. P. (2009) · Methods in molecular biology · doi:10.1007/978-1-59745-493-3_1 · Cited by 28 · see citing works
Self-citationCell cycling through development
Levine, E. M. (2004) · Development · doi:10.1242/dev.01180 · Cited by 24 · see citing works
Bouchikhi, F., Anizon, F., & Moreau, P. (2009) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2009.01.027 · Cited by 20 · see citing works
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Kumari, R., & Jat, P. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.645593 · Cited by 1,622 · see citing works
The DREAM complex: master coordinator of cell cycle-dependent gene expression
Sadasivam, S., & DeCaprio, J. A. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3556 · Cited by 524 · see citing works
Self-citationDuchon, A., & Herault, Y. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00104 · Cited by 181 · see citing works
Soppa, U., Schumacher, J., Florencio Ortiz, V., Pasqualon, T., Tejedor, F., & Becker, W. (2014) · Cell Cycle · doi:10.4161/cc.29104 · Cited by 189 · see citing works
“DYRK1A has been proposed to promote cell cycle exit and quiescence by phosphorylation of LIN52 on Ser28, which is required for the assembly of the DREAM complex.(40) However, Chen et al.”
BackgroundResultInfluentialHibaoui, Y., Grad, I., Letourneau, A., Sailani, M. R., Dahoun, S., Santoni, F. A., Gimelli, S., Guipponi, M., Pelte, M. F., Béna, F., et al. (2014) · EMBO Molecular Medicine · doi:10.1002/emmm.201302848 · Cited by 170 · see citing works
Wang, P., Karakose, E., Liu, H., Swartz, E., Ackeifi, C., Zlatanic, V., Wilson, J., González, B. J., Bender, A., Takane, K. K., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2018.12.005 · Cited by 162 · see citing works
Chen, J.-Y., Lin, J.-R., Tsai, F.-C., & Meyer, T. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.09.009 · Cited by 144 · see citing works
The role of cellular senescence and SASP in tumour microenvironment
Takasugi, M., Yoshida, Y., Hara, E., & Ohtani, N. (2023) · The FEBS Journal · doi:10.1111/febs.16381 · Cited by 144 · see citing works
Crosstalk between the Rb pathway and AKT signaling forms a quiescence-senescence switch.
Imai, Y., Takahashi, A., Hanyu, A., Hori, S., Sato, S., Naka, K., Hirao, A., Ohtani, N., & Hara, E. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.03.006 · Cited by 84 · see citing works
Atas-Ozcan, H., Brault, V., Duchon, A., & Herault, Y. (2021) · Genes · doi:10.3390/genes12111833 · Cited by 78 · see citing works
The Omnipresence of DYRK1A in Human Diseases
Deboever, E., Fistrovich, A., Hulme, C., & Dunckley, T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169355 · Cited by 77 · see citing works
Rammohan, M., Harris, E., Bhansali, R. S., Zhao, E., Li, L. S., & Crispino, J. D. (2022) · Oncogene · doi:10.1038/s41388-022-02245-6 · Cited by 68 · see citing works
- Authors
- Litovchick, L., Florens, L. A., Swanson, S. K., Washburn, M. P., & DeCaprio, J. A.
- Affiliations
- Brigham and Women's Hospital (US)
- Stowers Institute for Medical Research (US)
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2011-04-15
- Volume
- 25
- Issue
- 8
- Pages
- 801-813
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- PMC
- PMC3078706
- OpenAlex
- W2152349800
- Cited by
- 302
- References
- 62
- Citations by year
- 2026: 26 · 2025: 19 · 2024: 30 · 2023: 34 · 2022: 23 · 2021: 26 · 2020: 11 · 2019: 14 · 2018: 15 · 2017: 16 · 2016: 19 · 2015: 12 · 2014: 16 · 2013: 18 · 2012: 14
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Defense (W81XWH)
- National Cancer Institute (R01CA093804, P01CA050661, R01CA063113)
- Topics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- DYRK1A, DREAM complex, cell cycle quiescence, cellular senescence, p130, E2F4, retinoblastoma protein, Ras-induced senescence, kinase regulation, G0 quiescence
- MeSH terms
- Dyrk Kinases, Animals, Cell Cycle, Cell Line, Cells, Cultured, Humans, Nuclear Proteins, Phosphorylation, Protein-Tyrosine Kinases, Trans-Activators, Cellular Senescence, Protein Serine-Threonine Kinases, Tumor Suppressor Proteins, NIH 3T3 Cells, Cell Line, Tumor, Cell Proliferation, Transcription Factor DP1, E2F4 Transcription Factor, Retinoblastoma-Like Protein p130, Mice, Retinoblastoma-Binding Protein 4
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