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Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation
Open accessAbstract
Constitutive activation of growth factor signaling pathways paradoxically triggers a cell cycle arrest known as cellular senescence. In primary cells expressing oncogenic ras, this mechanism effectively prevents cell transformation. Surprisingly, attenuation of ERK/MAP kinase signaling by genetic inactivation of Erk2, RNAi-mediated knockdown of ERK1 or ERK2, or MEK inhibitors prevented the activation of the senescence mechanism, allowing oncogenic ras to transform primary cells. Mechanistically, ERK-mediated senescence involved the proteasome-dependent degradation of proteins required for cell cycle progression, mitochondrial functions, cell migration, RNA metabolism, and cell signaling. This senescence-associated protein degradation (SAPD) was observed not only in cells expressing ectopic ras , but also in cells that senesced due to short telomeres. Individual RNAi-mediated inactivation of SAPD targets was sufficient to restore senescence in cells transformed by oncogenic ras or trigger senescence in normal cells. Conversely, the anti-senescence viral oncoproteins E1A, E6, and E7 prevented SAPD. In human prostate neoplasms, high levels of phosphorylated ERK were found in benign lesions, correlating with other senescence markers and low levels of STAT3, one of the SAPD targets. We thus identified a mechanism that links aberrant activation of growth signaling pathways and short telomeres to protein degradation and cellular senescence.
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“It was recently shown that aberrant Ras/ERK signaling leads to senescence-associated protein degradation (SAPD), whose targets include proteins required for cell cycle progression, cell migration, mitochondrial functions, RNA metabolism, and cell signaling (Deschênes-Simard et al. 2013).”
From Cellular senescence and its effector programs (2014) · cites this paper as Deschênes-Simard et al. 2013
In the citing paper
“Inactivation of individual SAPD targets is sufficient for senescence induction.”
From Cellular senescence and its effector programs (2014) · cites this paper as Deschênes-Simard et al. 2013
In the citing paper
“PML and ERK were found in benign human prostatic hyperplasia- derived samples 85,86 .”
From Senescence and cancer — role and therapeutic opportunities (2022) · cites this paper as [86]
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Cites
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., & Lowe, S. W. (1997) · Cell · doi:10.1016/s0092-8674(00)81902-9 · Cited by 5,218
The senescence-associated secretory phenotype: the dark side of tumor suppression
Coppé, J.-P., Desprez, P.-Y., Krtolica, A., & Campisi, J. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102144 · Cited by 5,206
Induction of apoptosis in fibroblasts by c-myc protein
Evan, G. I., Wyllie, A. H., Gilbert, C. S., Littlewood, T. D., Land, H., Brooks, M. W., Waters, C. M., Penn, L. Z., & Hancock, D. C. (1992) · Cell · doi:10.1016/0092-8674(92)90123-t · Cited by 2,941
A DNA damage checkpoint response in telomere-initiated senescence
Fagagna, F. D. D., Reaper, P. M., Clay-Farrace, L., Fiegler, H., Carr, P., von Zglinicki, T., Saretzki, G., Carter, N. P., & Jackson, S. P. (2003) · Nature · doi:10.1038/nature02118 · Cited by 2,917
Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes
Land, H., Parada, L. F., & Weinberg, R. A. (1983) · Nature · doi:10.1038/304596a0 · Cited by 2,804
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
Xue, W., Zender, L., Miething, C., Dickins, R. A., Hernando, E., Krizhanovsky, V., Cordon-Cardo, C., & Lowe, S. W. (2007) · Nature · doi:10.1038/nature05529 · Cited by 2,473
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence
Narita, M., Nuñez, S., Heard, E., Narita, M., Lin, A. W., Hearn, S. A., Spector, D. L., Hannon, G. J., & Lowe, S. W. (2003) · Cell · doi:10.1016/s0092-8674(03)00401-x · Cited by 2,278
Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
DeNicola, G. M., Karreth, F. A., Humpton, T. J., Gopinathan, A., Wei, C., Frese, K., Mangal, D., Yu, K. H., Yeo, C. J., Calhoun, E. S., et al. (2011) · Nature · doi:10.1038/nature10189 · Cited by 2,277
BRAFE600-associated senescence-like cell cycle arrest of human naevi
Michaloglou, C., Vredeveld, L. C. W., Soengas, M. S., Denoyelle, C., Kuilman, T., van der Horst, C. M. A. M., Majoor, D. M., Shay, J. W., Mooi, W. J., & Peeper, D. S. (2005) · Nature · doi:10.1038/nature03890 · Cited by 2,160
Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
Chen, Z., Trotman, L. C., Shaffer, D., Lin, H.-K., Dotan, Z. A., Niki, M., Koutcher, J. A., Scher, H. I., Ludwig, T., Gerald, W., et al. (2005) · Nature · doi:10.1038/nature03918 · Cited by 1,993
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Palani, C. D., Ramanathapuram, L. V., Lam‐ubol, A., & Kurago, Z. (2017) · Oncotarget · doi:10.18632/oncotarget.23784 · Cited by 22
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Wu, G., Pen, J., Huang, Y., An, S., Liu, Y., Yang, Y., Hao, Q., Guo, X., & Xu, T. (2018) · Molecular Carcinogenesis · doi:10.1002/mc.22853 · Cited by 22
Iwamoto, N., D’Alessandro, L. A., Depner, S., Hahn, B., Kramer, B. A., Lucarelli, P., Vlasov, A., Stepath, M., Böhm, M. E., Deharde, D., et al. (2016) · Science Signaling · doi:10.1126/scisignal.aab1967 · Cited by 20
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Self-citationLi, F., Pascal, L. E., Wang, K., Zhou, Y., Balasubramani, G. K., O’Malley, K. J., Dhir, R., He, K., Stolz, D. B., DeFranco, D. B., et al. (2020) · PubMed Central · Cited by 20
Jeon, M., Chauhan, K. M., Szeto, G. L., Kyoung, M., & An, S. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.101675 · Cited by 22
Huang, P. C., Guo, L., Xi, J., & Wang, D. (2017) · Tumor Biology · doi:10.1177/1010428317713389 · Cited by 20
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Saint‐Germain, E., Mignacca, L., Huot, G., Acevedo, M., Moineau‐Vallée, K., Calabrese, V., Bourdeau, V., Rowell, M., Ilangumaran, S., Lessard, F., et al. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-1503 · Cited by 19
Self-citationChakraborty, S., Mishra, J., Roy, A., Niharika, N., Manna, S., Baral, T., Nandi, P., Patra, S., & Patra, S. K. (2024) · Biochimie · doi:10.1016/j.biochi.2024.05.007 · Cited by 18
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Long-term inhibition of PDE5 ameliorates aging-induced changes in rat testis
Sokanovic, S. J., Čapo, I., Medar, M. L., Andrić, S. A., & Kostic, T. S. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2018.04.007 · Cited by 18
Targeting ribosome biogenesis reinforces ERK-dependent senescence in pancreatic cancer
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Ferbeyre, G. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.06.016 · Cited by 16
Self-citationKo, T., Sharma, R., & Li, S. (2019) · Oncogene · doi:10.1038/s41388-019-1022-0 · Cited by 18
Palazzo, A., Hernández‐Vargas, H., Goehrig, D., Médard, J., Vindrieux, D., Flaman, J., & Bernard, D. (2022) · Cancer Letters · doi:10.1016/j.canlet.2022.215850 · Cited by 15
Laliberté, C., Bossé, B., Bourdeau, V., Prieto, L. I., Perron-Deshaies, G., Vuong, N., Igelmann, S., Aguilar, L. C., Oeffinger, M., Baker, D. J., et al. (2024) · Biomedicines · doi:10.3390/biomedicines12051089 · Cited by 16
Self-citationSu, L., Du, H., Dong, X., Zhang, X., & Lou, Z. (2016) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.15-128 · Cited by 15
Learning about the Importance of Mutation Prevention from Curable Cancers and Benign Tumors
Wang, G., Chen, L., Yu, B., Zellmer, L., Xu, N., & Liao, D. J. (2016) · Journal of Cancer · doi:10.7150/jca.13832 · Cited by 15
Liang, X., & Jian-xin, J. (2021) · Oncology Reports · doi:10.3892/or.2021.8033 · Cited by 15
RetractedFernandes, S. E., & Saini, D. K. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.744013 · Cited by 14
TMEFF2 modulates the AKT and ERK signaling pathways.
Chen, X., & Ruiz-Echevarría, M. J. (2013) · Europe PMC (PubMed Central) · Cited by 14
Patel, T., Clipstone, C., Girija, U. V., Ahmad, Z., & Singh, N. (2025) · Nanomaterials · doi:10.3390/nano15231766 · Cited by 13
Teng, C., Chen, J., Shen, L., Chen, S., & Chen, G. (2025) · Cancer Drug Resistance · doi:10.20517/cdr.2024.178 · Cited by 14
Molecular Heterogeneity in BRAF-Mutant Gliomas: Diagnostic, Prognostic, and Therapeutic Implications
Lhermitte, B., Wolf, T., Chenard, M. P., Coca, A. H., Todeschi, J., Proust, F., Hirsch, É., Schött, R., Noël, G., Guérin, É., et al. (2023) · Cancers · doi:10.3390/cancers15041268 · Cited by 13
Petersen, C. H., Mahmood, B., Badsted, C., Dahlby, T., Rasmussen, H. B., Hansen, M. B., & Bindslev, N. (2019) · BMC Cancer · doi:10.1186/s12885-019-5833-8 · Cited by 11
Prijić, S., Ugrina, I., Labar, B., Nemet, D., Batinić, J., Zadro, R., Ries, S., Gjadrov-Kuvedžić, K., Davidović, S., & Batinić, D. (2014) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428194.2014.990012 · Cited by 12
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Lopes‐Paciencia, S., Bourdeau, V., Rowell, M., Amirimehr, D., Guillon, J., Kalegari, P., Barua, A., Trinh, V. Q., Azzi, F., Turcotte, S., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114044 · Cited by 13
Self-citationNaturalistic Stress Hormone Levels Drive Cumulative Epigenomic Changes along the Cellular Lifespan
Zannas, A. S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168778 · Cited by 9
Trapp-Fragnet, L., Schermuly, J., Kohn, M., Bertzbach, L. D., Pfaff, F., Denesvre, C., Kaufer, B. B., & Härtle, S. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1010006 · Cited by 11
Lin, X.-W., Fan, Z., Liu, Y. H., Li, J., Ma, Q., & Yan, R. H. (2021) · Insect Molecular Biology · doi:10.1111/imb.12721 · Cited by 10
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Wu, J., Xia, X., Wu, Z., Zhao, H., Cao, H., Sun, D., Wang, R.-M., Sun, J., Liu, Y., & Rui-chen, G. (2013) · Biomedicine & Preventive Nutrition · doi:10.1016/j.bionut.2013.08.002 · Cited by 10
Mikawa, T., Kameda, M., Ikari, S., Shibata, E., Liu, S., Miyagawa, S., Ono, K., Ito, T., Yoshizawa, A., Sugimoto, M., et al. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02502-6 · Cited by 10
Marciniak, B., Kciuk, M., Mujwar, S., Rajamanikandan, S., Bukowski, K., & Gruszka, R. (2023) · Cancers · doi:10.3390/cancers15184442 · Cited by 10
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Dworak, H., Rozmaric, T., Grillari, J., & Ogrodnik, M. B. (2025) · FEBS Letters · doi:10.1002/1873-3468.70037 · Cited by 8
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Ling, J., Sckaff, M., Tiwari, M., Chen, Y., Li, J., Jones, J., & Sen, G. L. (2020) · Journal of Cell Science · doi:10.1242/jcs.249102 · Cited by 7
Lu, X., Yuan, F., Qiao, L., Liu, Y., Gu, Q., Qi, X., Li, J., Li, D., & Liu, M. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.116099 · Cited by 8
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Toro, N. D., Lessard, F., Bouchard, J., Mobasheri, N., Guillon, J., Igelmann, S., Tardif, S., Buffard, T., Bourdeau, V., Brakier‐Gingras, L., et al. (2021) · Biology Open · doi:10.1242/bio.058688 · Cited by 8
Self-citationRademacher, D. J., Exline, J. E., & Foecking, E. M. (2025) · Biomedicines · doi:10.3390/biomedicines13061400 · Cited by 8
Hu, B., Meng, X., Zhang, Y., Hossain, M., Wu, L., Zhang, Y., Peng, X., & Zhang, X. (2018) · Oncology Reports · doi:10.3892/or.2018.6237 · Cited by 6
Guda, B. B., PUSHKAREV, V. V., Ковзун, О. І., Pushkarev, V. P., & Tronko, M. D. (2019) · Шпитальна хірургія Журнал імені Л Я Ковальчука · doi:10.11603/2414-4533.2019.3.10551 · Cited by 6
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Nowacka, J. D., Baumgartner, C., Pelorosso, C., Roth, M., Zuber, J. A., & Baccarini, M. (2016) · Oncotarget · doi:10.18632/oncotarget.12555 · Cited by 5
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Li, J., Kovach, A. R., DeMonia, M., Slemmons, K. K., Oristian, K. M., Chen, C., & Linardic, C. M. (2021) · Scientific Reports · doi:10.1038/s41598-021-95355-2 · Cited by 6
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Ma, J., Yang, W., Chen, F.-M., He, Q., Ma, H.-L., Li, C., Liang, M.-L., Zhong, J.-Q., Zhang, X., & Li, F. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117068 · Cited by 4
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Minichino, D. E., Lv, K., Chu, N., Tong, W., & Behrens, E. M. (2022) · Journal of Leukocyte Biology · doi:10.1002/jlb.3a0122-075rr · Cited by 3
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Yan, J., Zhang, Y., Mao, G., Yu, J., Zhou, T., & Hao, J. (2025) · MedComm – Oncology · doi:10.1002/mog2.70029 · Cited by 3
Ding, Y., Liu, Z., Liao, Y., Huang, K., Jiao, X., Zhu, J., Wang, H., Tao, Q., Guo, J., Xiong, S., et al. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-07306-4 · Cited by 3
Jing, J., Yan, M., Veeraraghavan, V. P., Mohan, S. K., & Meng, Q. (2022) · Applied Nanoscience · doi:10.1007/s13204-021-02229-0 · Cited by 3
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Pal, A. (2025) · Advances in pharmacology · doi:10.1016/bs.apha.2025.01.019 · Cited by 2
Fulciniti, M., Yao, Y., Perini, T., Ng, J. F., Schavgoulidze, A., Deng, S., Cui, J., Encinas, J., Ladisa, F., Young, R. M., et al. (2025) · Blood Cancer Discovery · doi:10.1158/2643-3230.bcd-25-0048 · Cited by 2
Targeted protein degradation as a tumor suppressor
Arat, N. Ö., & Harrington, L. A. (2014) · Cell Cycle · doi:10.4161/15384101.2014.980700 · Cited by 2
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Self-citationTsao, W.-C., Buj, R., Aird, K. M., Sidorova, J. M., & Eckert, K. A. (2021) · PLoS ONE · doi:10.1371/journal.pone.0251188 · Cited by 2
Li, Y., Xiang, Z.-Y., Xiong, J., Hou, Z.-W., Zhu, Z., & Bao, W.-W. (2021) · Acta Histochemica · doi:10.1016/j.acthis.2021.151733 · Cited by 2
Lin, T. F., & Prados, M. D. (2016) · Pediatric oncology · doi:10.1007/978-3-319-30789-3_3 · Cited by 2
Liu, J., Ma, Z.-L., Su, R., & Huang, K. (2020) · PubMed Central · doi:10.7518/hxkq.2020.05.004 · Cited by 2
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Göktuna, S. İ. (2021) · EXCLI journal · doi:10.17179/excli2021-4578 · Cited by 1
Chen, J.-Y., Hug, C. B., Reyes, J. S., Tian, C., Gerosa, L., Fröhlich, F., Ponsioen, B., Snippert, H. J. G., Spencer, S. L., Jambhekar, A., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.10.06.511142 · Cited by 1
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Ben‐Porath, I. (2014) · Springer eBooks · doi:10.1007/978-94-017-9325-4_1
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Bustos, S. O. (2014) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2014.tde-21052014-110608
Kochetkova, E. Y., Bykova, T. V., Zubova, S. G., & Pospelova, T. V. (2014) · Cell and Tissue Biology · doi:10.1134/s1990519x14050034
Wu, J., Xia, X., Wu, Z., Zhao, H., Sun, D., Wang, R.-M., Liu, Y., Sun, J., & Rui-chen, G. (2013) · Biomedicine & Preventive Nutrition · doi:10.1016/j.bionut.2013.06.006
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Bauer, J. (2019) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-7239
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Lagnado, A. B., Victorelli, S. G., & Passos, J. F. (2020) · Healthy ageing and longevity · doi:10.1007/978-3-030-44903-2_11
Tsao, W.-C., Buj, R., Aird, K. M., Sidorova, J. M., & Eckert, K. A. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.07.01.180455
Leung, C. S., Kosyk, O., Welter, E. M., Dietrich, N., Archer, T., & Zannas, A. S. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4077247
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Acevedo, M., Vernier, M., Mignacca, L., Lessard, F., Huot, G., Moiseeva, O. V., Bourdeau, V., & Ferbeyre, G. (2023) · doi:10.1158/0008-5472.22409091.v1
Self-citationAcevedo, M., Vernier, M., Mignacca, L., Lessard, F., Huot, G., Moiseeva, O. V., Bourdeau, V., & Ferbeyre, G. (2023) · doi:10.1158/0008-5472.22409091
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Carvalho, C. (2018) · theses.fr (ABES) · doi:10.70675/7cafc6a4za30dz467dz81a1z7033a7846a52
Generation of antisense RNAs at convergent gene loci in cells undergoing senescence
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Metadata
- Authors
- Deschênes-Simard, X., Gaumont-Leclerc, M.-F., Bourdeau, V., Lessard, F., Moiseeva, O., Forest, V., Igelmann, S., Mallette, F. A., Saba-El-Leil, M. K., Meloche, S., Saad, F., Mes-Masson, A.-M., & Ferbeyre, G.
- Affiliations
- Université de Montréal (CA)
- Centre Hospitalier de l’Université de Montréal (CA)
- Institute for Research in Immunology and Cancer (CA)
- ORCID
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2013-04-15
- Volume
- 27
- Issue
- 8
- Pages
- 900-915
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- PMC
- PMC3650227
- OpenAlex
- W1978818809
- Cited by
- 194
- References
- 60
- Citations by year
- 2026: 4 · 2025: 14 · 2024: 7 · 2023: 19 · 2022: 16 · 2021: 19 · 2020: 18 · 2019: 19 · 2018: 19 · 2017: 14 · 2016: 13 · 2015: 9 · 2014: 16 · 2013: 7
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- cellular senescence, ERK signaling, oncogenic Ras, protein degradation, short telomeres, tumor suppressor activity, MEK inhibitors, STAT3, viral oncoproteins, prostate cancer, proteasome
- MeSH terms
- Animals, Cell Line, Cell Transformation, Neoplastic, Female, Fibroblasts, Humans, Male, Mice, Inbred BALB C, Prostatic Neoplasms, Cellular Senescence, Mice, Knockout, ras Proteins, MAP Kinase Signaling System, Tumor Suppressor Proteins, Proteasome Endopeptidase Complex, Mice, Gene Knockdown Techniques, Proteolysis
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