The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
A zebrafish nanos-related gene is essential for the development of primordial germ cells
Open accessAbstract
Asymmetrically distributed cytoplasmic determinants collectively termed germ plasm have been shown to play an essential role in the development of primordial germ cells (PGCs). Here, we report the identification of a nanos-like (nanos 1) gene, which is expressed in the germ plasm and in the PGCs of the zebrafish. We find that several mechanisms act in concert to restrict the activity of Nanos1 to the germ cells including RNA localization and control over the stability and translatability of the RNA. Reducing the level of Nanos1 in zebrafish embryos revealed an essential role for the protein in ensuring proper migration and survival of PGCs in this vertebrate model organism.
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Cites
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Bmp4 is required for the generation of primordial germ cells in the mouse embryo
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The mouse homolog of Drosophila Vasa is required for the development of male germ cells
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The mouse Dazla gene encodes a cytoplasmic protein essential for gametogenesis
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CRISPRscan: designing highly efficient sgRNAs for CRISPR-Cas9 targeting in vivo
Moreno-Mateos, M. A., Vejnar, C. E., Beaudoin, J.-D., Fernandez, J. P., Mis, E. K., Khokha, M. K., & Giraldez, A. J. (2015) · Nature Methods · doi:10.1038/nmeth.3543 · Cited by 1,290
Spontaneous differentiation of germ cells from human embryonic stem cells in vitro
Clark, A. T. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh088 · Cited by 503
A C. elegans LSD1 Demethylase Contributes to Germline Immortality by Reprogramming Epigenetic Memory
Katz, D. J., Edwards, T. M., Reinke, V., & Kelly, W. G. (2009) · Cell · doi:10.1016/j.cell.2009.02.015 · Cited by 344
Differential Regulation of Germline mRNAs in Soma and Germ Cells by Zebrafish miR-430
Mishima, Y., Giraldez, A. J., Takeda, Y., Fujiwara, T., Sakamoto, H., Schier, A. F., & Inoue, K. (2006) · Current Biology · doi:10.1016/j.cub.2006.08.086 · Cited by 321
Extavour, C. G., Pang, K., Matus, D. Q., & Martindale, M. Q. (2005) · Evolution & Development · doi:10.1111/j.1525-142x.2005.05023.x · Cited by 144
Metadata
- Authors
- Köprunner, M., Thisse, C., Thisse, B., & Raz, E.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2001-11-01
- Volume
- 15
- Issue
- 21
- Pages
- 2877-2885
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2150014745
- Cited by
- 508
- References
- 36
- Type
- posted content
- Language
- en
- Open access
- diamond
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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