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Exploiting the bad eating habits of Ras-driven cancers
Open accessAbstract
Oncogenic Ras promotes glucose fermentation and glutamine use to supply central carbon metabolism, but how and why have only emerged recently. Ras-mediated metabolic reprogramming generates building blocks for growth and promotes antioxidant defense. To fuel metabolic pathways, Ras scavenges extracellular proteins and lipids. To bolster metabolism and mitigate stress, Ras activates cellular self-cannibalization and recycling of proteins and organelles by autophagy. Targeting these distinct features of Ras-driven cancers provides novel approaches to cancer therapy.
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Self-citation
Metadata
- Authors
- White, E.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2013-10-01
- Volume
- 27
- Issue
- 19
- Pages
- 2065-2071
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2170661703
- Cited by
- 179
- References
- 22
- Type
- posted content
- Language
- en
- Open access
- diamond
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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