Loss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis

Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia

The Cancer Genome Atlas Research Network (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1301689 · Cited by 5,078

A decade of exploring the cancer epigenome—biological and translational implications

Baylin, S. B., & Jones, P. A. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3130 · Cited by 2,871

Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

Figueroa, M. E., Abdel-Wahab, O., Lu, C., Ward, P. S., Patel, J., Shih, A., Li, Y., Bhagwat, N., Vasanthakumar, A., Fernandez, H. F., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.11.015 · Cited by 2,766

The accessible chromatin landscape of the human genome

Thurman, R. E., Rynes, E., Humbert, R., Vierstra, J., Maurano, M. T., Haugen, E., Sheffield, N. C., Stergachis, A. B., Wang, H., Vernot, B., et al. (2012) · Nature · doi:10.1038/nature11232 · Cited by 2,679

An atlas of active enhancers across human cell types and tissues

The FANTOM Consortium, Andersson, R., Gebhard, C., Miguel-Escalada, I., Hoof, I., Bornholdt, J., Boyd, M., Chen, Y., Zhao, X., Schmidl, C., et al. (2014) · Nature · doi:10.1038/nature12787 · Cited by 2,550

Genome-scale DNA methylation maps of pluripotent and differentiated cells

Meissner, A., Mikkelsen, T. S., Gu, H., Wernig, M., Hanna, J., Sivachenko, A., Zhang, X., Bernstein, B. E., Nusbaum, C., Jaffe, D. B., et al. (2008) · Nature · doi:10.1038/nature07107 · Cited by 2,536

Function and information content of DNA methylation

Schübeler, D. (2015) · Nature · doi:10.1038/nature14192 · Cited by 2,060

Mutation in TET2 in Myeloid Cancers

Delhommeau, F., Dupont, S., Valle, V. D., James, C., Trannoy, S., Massé, A., Kosmider, O., Le Couedic, J.-P., Robert, F., Alberdi, A., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810069 · Cited by 1,776

DNA-binding factors shape the mouse methylome at distal regulatory regions

Stadler, M. B., Murr, R., Burger, L., Ivanek, R., Lienert, F., Schöler, A., Nimwegen, E. V., Wirbelauer, C., Oakeley, E. J., Gaidatzis, D., et al. (2011) · Nature · doi:10.1038/nature10716 · Cited by 1,383

Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2

Ko, M., Huang, Y., Jankowska, A. M., Pape, U. J., Tahiliani, M., Bandukwala, H. S., An, J., Lamperti, E. D., Koh, K. P., Ganetzky, R. D., et al. (2010) · Nature · doi:10.1038/nature09586 · Cited by 1,340

Integrated Clinical Genotype-Phenotype Characteristics of Blastic Plasmacytoid Dendritic Cell Neoplasm

Yin, C. C., Pemmaraju, N., You, M. J., Li, S., Xu, J., Wang, W., Tang, Z., Alswailmi, O. A., Bhalla, K. N., Qazilbash, M. H., et al. (2021) · Cancers · doi:10.3390/cancers13235888 · Cited by 38

Genomic Aging, Clonal Hematopoiesis, and Cardiovascular Disease

Natarajan, P. (2022) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.122.318181 · Cited by 35

The Elusive Role of 5′-Hydroxymethylcytosine

Szyf, M. (2016) · Epigenomics · doi:10.2217/epi-2016-0076 · Cited by 34

Transcriptional networks in acute myeloid leukemia

Thoms, J. A. I., Beck, D., & Pimanda, J. E. (2019) · Genes Chromosomes and Cancer · doi:10.1002/gcc.22794 · Cited by 33

Alternative roles for oxidized mCs and TETs

Cimmino, L., & Aifantis, I. (2016) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2016.11.003 · Cited by 35

Loss of TET2 Affects Proliferation and Drug Sensitivity through Altered Dynamics of Cell-State Transitions

Morinishi, L. S., Kochanowski, K., Levine, R. L., Wu, L. F., & Altschuler, S. J. (2020) · Cell Systems · doi:10.1016/j.cels.2020.06.003 · Cited by 32

Role of TET dioxygenases in the regulation of both normal and pathological hematopoiesis

Joshi, K., Zhang, L., Breslin, P., Kini, A. R., & Zhang, J. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-022-02496-x · Cited by 31

Pre-neoplastic epigenetic disruption of transcriptional enhancers in chronic inflammation

Planello, A. C., Singhania, R., Kron, K. J., Bailey, S. D., Roulois, D., Lupien, M., Line, S. R. P., de Souza, A. P., & Carvalho, D. D. D. (2016) · Oncotarget · doi:10.18632/oncotarget.7513 · Cited by 31

C/EBPα and GATA-2 Mutations Induce Bilineage Acute Erythroid Leukemia through Transformation of a Neomorphic Neutrophil-Erythroid Progenitor

Genua, C. D., Valletta, S., Buono, M., Stoilova, B., Sweeney, C., Rodríguez-Meira, A., Grover, A., Drissen, R., Meng, Y., Beveridge, R. D. D., et al. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.03.022 · Cited by 34

Recent advances in understanding DNA methylation of prostate cancer

Shin, H. J., Hua, J. T., & Li, H. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1182727 · Cited by 32

Novel Epigenetic Controlling of Hypoxia Pathway Related to Overexpression and Promoter Hypomethylation of TET1 and TET2 in RPE Cells

Alivand, M. R., Soheili, Z., Pornour, M., Solali, S., & Sabouni, F. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25965 · Cited by 29

Epigenetic dysregulation of hematopoietic stem cells and preleukemic state

Kunimoto, H., & Nakajima, H. (2017) · International Journal of Hematology · doi:10.1007/s12185-017-2257-6 · Cited by 30

MYC Regulation of D2HGDH and L2HGDH Influences the Epigenome and Epitranscriptome

Qiu, Z., Lin, A., Jiang, S., Elkashef, S. M., Myers, J., Srikantan, S., Sasi, B. K., Cao, J. Z., Godley, L. A., Rakheja, D., et al. (2020) · Cell chemical biology · doi:10.1016/j.chembiol.2020.02.002 · Cited by 31

Alterations of regulatory factors and DNA methylation pattern in thyroid cancer

Iancu, I. V., Botezatu, A., Plesa, A., Huică, I., Fudulu, A., Albulescu, A., Bostan, M., Mihaila, M. A., Grancea, C., Manda, D. A., et al. (2020) · Cancer Biomarkers · doi:10.3233/cbm-190871 · Cited by 29

The Potential Role of Epigenetic Mechanisms in the Development of Retinitis Pigmentosa and Related Photoreceptor Dystrophies

Dvoriantchikova, G., Lypka, K. R., & Ivanov, D. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.827274 · Cited by 28

Epigenomics-Guided Drug Development: Recent Advances in Solving the Cancer Treatment “jigsaw puzzle”

Dzobo, K. (2019) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2018.0206 · Cited by 29

Expression and prognosis analysis of TET family in acute myeloid leukemia

Zhang, T., Zhao, Y., Zhao, Y., & Zhou, J. (2020) · Aging · doi:10.18632/aging.102928 · Cited by 28

TET2 mutation in acute myeloid leukemia: biology, clinical significance, and therapeutic insights

Gao, Q., Shen, K., & Xiao, M. (2024) · Clinical Epigenetics · doi:10.1186/s13148-024-01771-2 · Cited by 35

Epigenetic modifications in acute myeloid leukemia: The emerging role of circular RNAs (Review)

Issah, M. A., Wu, D., Zhang, F., Zheng, W., Liu, Y., Fu, H., Zhou, H., Chen, R., & Shen, J. (2021) · International Journal of Oncology · doi:10.3892/ijo.2021.5287 · Cited by 26

Dissecting TET2 Regulatory Networks in Blood Differentiation and Cancer

Lazarenkov, A., & Sardina, J. L. (2022) · Cancers · doi:10.3390/cancers14030830 · Cited by 26

Emerging epigenetic therapeutics for myeloid leukemia: modulating demethylase activity with ascorbate

Das, A. B., Smith-Díaz, C. C., & Vissers, M. C. M. (2020) · Haematologica · doi:10.3324/haematol.2020.259283 · Cited by 25

PAX9 Determines Epigenetic State Transition and Cell Fate in Cancer

Zhao, Z., Szczepanski, A. P., Tsuboyama, N., Abdala‐Valencia, H., Goo, Y. A., Singer, B. D., Bartom, E. T., Yue, F., & Wang, L. (2021) · Cancer Research · doi:10.1158/0008-5472.can-21-1114 · Cited by 25

Role of Enhancers in Development and Diseases

Maurya, S. S. (2021) · Epigenomes · doi:10.3390/epigenomes5040021 · Cited by 26

TET2 is required to suppress mTORC1 signaling through urea cycle with therapeutic potential

He, J., Lin, M., Zhang, X., Zhang, R., Tian, T., Zhou, Y., Dong, W., Yang, Y., Sun, X., Dai, Y., et al. (2023) · Cell Discovery · doi:10.1038/s41421-023-00567-7 · Cited by 27

Impact of combinatorial dysfunctions of Tet2 and Ezh2 on the epigenome in the pathogenesis of myelodysplastic syndrome

Hasegawa, N., Oshima, M., Sashida, G., Matsui, H., Koide, S., Saraya, A., Wang, C., Muto, T., Takane, K., Kaneda, A., et al. (2016) · Leukemia · doi:10.1038/leu.2016.268 · Cited by 25

Oncogenic ZEB2 activation drives sensitivity toward KDM1A inhibition in T-cell acute lymphoblastic leukemia

Goossens, S., Peirs, S., Loocke, W. V., Wang, J., Takawy, M., Matthijssens, F., Sonderegger, S., Haigh, K., Nguyen, T. M., Vandamme, N., et al. (2017) · Blood · doi:10.1182/blood-2016-06-721191 · Cited by 25

Mutant IDH : A Targetable Driver of Leukemic Phenotypes Linking Metabolism, Epigenetics and Transcriptional Regulation

Garrett-Bakelman, F. E., & Melnick, A. M. (2016) · Epigenomics · doi:10.2217/epi-2016-0008 · Cited by 25

Clonal dynamics in a single AML case tracked for 9 years reveals the complexity of leukemia progression

Kim, T., Yoshida, K., Kim, Y. K., Tyndel, M. S., Park, H. J., Choi, S., Ahn, J., Jung, S.-H., Yang, D.-H., Lee, J.-J., et al. (2015) · Leukemia · doi:10.1038/leu.2015.264 · Cited by 24

Identification of SLC20A1 and SLC15A4 among other genes as potential risk factors for combined pituitary hormone deficiency

Simm, F., Griesbeck, A., Choukair, D., Weiß, B., Paramasivam, N., Klammt, J., Schlesner, M., Wiemann, S., Martínez, C., Hoffmann, G. F., et al. (2017) · Genetics in Medicine · doi:10.1038/gim.2017.165 · Cited by 24

A role for TET2 in parathyroid carcinoma

Barazeghi, E., Gill, A. J., Sidhu, S. B., Norlén, O., Dina, R. E., Palazzo, F. F., Hellman, P., Stalberg, P. L. H., & Westin, G. (2017) · Endocrine Related Cancer · doi:10.1530/erc-17-0009 · Cited by 24

Different roles of E proteins in t(8;21) leukemia: E2-2 compromises the function of AETFC and negatively regulates leukemogenesis

Liu, N., Song, J., Xie, Y., Wang, X.-L., Rong, B., Man, N., Zhang, M.-M., Zhang, Q., Gao, F.-F., Du, M., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1809327116 · Cited by 23

AML displays increased CTCF occupancy associated with aberrant gene expression and transcription factor binding

Mujahed, H., Miliara, S., Neddermeyer, A., Bengtzén, S., Nilsson, C. C., Deneberg, S., Cordeddu, L., Ekwall, K., Lennartsson, A., & Lehmann, S. (2020) · Blood · doi:10.1182/blood.2019002326 · Cited by 24

Impact of DNA methylation programming on normal and pre-leukemic hematopoiesis

Langstein, J., Milsom, M. D., & Lipka, D. B. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.09.008 · Cited by 25

Long Non-coding RNAs as Functional and Structural Chromatin Modulators in Acute Myeloid Leukemia

Wurm, A. A., & Pina, C. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00899 · Cited by 22

PU.1-Dependent Enhancer Inhibition Separates Tet2 -Deficient Hematopoiesis from Malignant Transformation

Aivalioti, M. M., Bartholdy, B. A., Pradhan, K., Bhagat, T. D., Zintiridou, A., Jeong, J. J., Thiruthuvanathan, V. J., Pujato, M., Paranjpe, A., Zhang, C., et al. (2022) · Blood Cancer Discovery · doi:10.1158/2643-3230.bcd-21-0226 · Cited by 22

RUNX1-ETO: Attacking the Epigenome for Genomic Instable Leukemia

van der Kouwe, E., & Staber, P. B. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20020350 · Cited by 24

TET2–BCLAF1 transcription repression complex epigenetically regulates the expression of colorectal cancer gene Ascl2 via methylation of its promoter

Shang, Y., Jiang, T., Ran, L., Hu, W., Wu, Y., Ye, J., Peng, Z., Chen, L., & Wang, R. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102095 · Cited by 22

Epigenetic Mechanisms in Leukemias and LymphomasPreprint

Duy, C., Béguelin, W., & Melnick, A. M. (2020) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a034959 · Cited by 23

Modeling clonal hematopoiesis in umbilical cord blood cells by CRISPR/Cas9

Christen, F., Hablesreiter, R., Hoyer, K., Hennch, C., Maluck-Böttcher, A., Segler, A., Madadi, A., Frick, M., Bullinger, L., Briest, F., et al. (2021) · Leukemia · doi:10.1038/s41375-021-01469-x · Cited by 22

Molecular pathogenesis of progression to myeloid leukemia from TET-insufficient status

Shrestha, R., Sakata‐Yanagimoto, M., Maie, K., Oshima, M., Ishihara, M., Suehara, Y., Fukumoto, K., Nakajima‐Takagi, Y., Matsui, H., Kato, T., et al. (2020) · Blood Advances · doi:10.1182/bloodadvances.2019001324 · Cited by 22

Clonal Hematopoiesis and Premalignant DiseasesPreprint

Kaner, J. D., Desai, P. M., Mencia-Trinchant, N., Guzmán, M. L., Roboz, G. J., & Hassane, D. C. (2019) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a035675 · Cited by 20

Epigenetic Modification of Cytosines in Hematopoietic Differentiation and Malignant Transformation

An, J., & Ko, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021727 · Cited by 21

The Role of H3K4 Trimethylation in CpG Islands Hypermethylation in Cancer

Zardo, G. (2021) · Biomolecules · doi:10.3390/biom11020143 · Cited by 20

p300 suppresses the transition of myelodysplastic syndromes to acute myeloid leukemia

Man, N., Martín, G. M., Karl, D. L., Sun, J., Liu, F., Yang, Q., Torres‐Martín, M., Itonaga, H., Martínez, C., Shi, C., et al. (2021) · JCI Insight · doi:10.1172/jci.insight.138478 · Cited by 19

Epigenetic modifications and targeted therapy in pediatric acute myeloid leukemia

Xu, H., Wen, Y., Jin, R., & Chen, H. (2022) · Frontiers in Pediatrics · doi:10.3389/fped.2022.975819 · Cited by 17

Causes, effects, and clinical implications of perturbed patterns within the cancer epigenome

Oleksiewicz, U., & Machnik, M. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.12.014 · Cited by 18

Perturbing TET2 condensation promotes aberrant genome-wide DNA methylation and curtails leukaemia cell growth

Guo, L., Hong, T., Lee, Y., Hu, X., Pan, G., Zhao, R., Yang, Y., Yang, J., Cai, X., Rivera, L., et al. (2024) · Nature Cell Biology · doi:10.1038/s41556-024-01496-7 · Cited by 17

HDAC4 inhibition disrupts TET2 function in high-risk MDS and AML

Huang, F., Sun, J., Chen, W., He, X., Zhu, Y., Dong, H., Wang, H., Li, Z., Zhang, L., Khaled, S. K., et al. (2020) · Aging · doi:10.18632/aging.103605 · Cited by 17

The Impact of the Cellular Origin in Acute Myeloid Leukemia: Learning From Mouse Models

Fisher, J. N., Kalleda, N., Stavropoulou, V., & Schwaller, J. (2019) · HemaSphere · doi:10.1097/hs9.0000000000000152 · Cited by 19

TET2 and DNMT3A mutations and exceptional response to 4′-thio-2′-deoxycytidine in human solid tumor models

Yang, S. X., Hollingshead, M. G., Rubinstein, L., Nguyen, D., Laranjeira, A. B. A., Kinders, R. J., Difilippantonio, M. J., & Doroshow, J. H. (2021) · Journal of Hematology & Oncology · doi:10.1186/s13045-021-01091-5 · Cited by 16

Acute myeloid leukemia: novel mutations and their clinical implications.

Makkar, H., Majhi, R. K., Goel, H., Gupta, A., Chopra, A., Tanwar, P., & Seth, R. K. (2023) · PubMed Central · Cited by 16

Harnessing the potential of epigenetic therapies for childhood acute myeloid leukemia

Newcombe, A., Gibson, B. E. S., & Keeshan, K. (2018) · Experimental Hematology · doi:10.1016/j.exphem.2018.03.008 · Cited by 16

Epigenetic deregulation in myeloid malignancies

Huang, H.-T., & Figueroa, M. E. (2021) · Blood · doi:10.1182/blood.2019004262 · Cited by 21

Dysregulated TET Family Genes and Aberrant 5mC Oxidation in Breast Cancer: Causes and Consequences

Xu, B., Wang, H., & Tan, L. (2021) · Cancers · doi:10.3390/cancers13236039 · Cited by 16

Molecular Features of Blastic Plasmacytoid Dendritic Cell Neoplasm

Sapienza, M. R., & Pileri, S. A. (2020) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2020.01.002 · Cited by 16

Role of non-coding RNAs in osteoporosis

Baniasadi, M., Talebi, S., Mokhtari, K., Zabolian, A. H., Khosroshahi, E. M., Entezari, M., Dehkhoda, F., Nabavi, N., & Hashemi, M. (2023) · Pathology - Research and Practice · doi:10.1016/j.prp.2023.155036 · Cited by 19

Single-Cell Epigenomics in Cancer: Charting a Course to Clinical Impact

Bond, D. R., Uddipto, K., Enjeti, A. K., & Lee, H. J. (2020) · Epigenomics · doi:10.2217/epi-2020-0046 · Cited by 15

RUNX1/CEBPA Mutation in Acute Myeloid Leukemia Promotes Hypermethylation and Indicates for Demethylation Therapy

Romanova, E. I., Zubritskiy, A. V., Lioznova, A. V., Ogunleye, A. J., Golotin, V., Guts, A. A., Lennartsson, A., Demidov, O. N., & Medvedeva, Y. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911413 · Cited by 15

Low Ten-eleven-translocation 2 (TET2) transcript level is independent of TET2 mutation in patients with myeloid neoplasms

Scopim‐Ribeiro, R., Machado‐Neto, J. A., Campos, P. D. M., Niemann, F. S., Lorand-Metze, I. G. H., Costa, F. F., Saad, S. T. O., & Traina, F. (2016) · Diagnostic Pathology · doi:10.1186/s13000-016-0476-4 · Cited by 15

DNA hydroxymethylation is associated with disease severity and persists at enhancers of oncogenic regions in multiple myeloma

Alberge, J.-B., Magrangeas, F., Wagner, M., Denié, S., Guérin‐Charbonnel, C., Campion, L., Attal, M., Avet‐Loiseau, H., Carell, T., Moreau, P., et al. (2020) · Clinical Epigenetics · doi:10.1186/s13148-020-00953-y · Cited by 14

Epigenetics in a Spectrum of Myeloid Diseases and Its Exploitation for Therapy

Maher, M., Diesch, J., Pannérer, M.-M. L., & Buschbeck, M. (2021) · Cancers · doi:10.3390/cancers13071746 · Cited by 14

Tumour suppressor TET2 safeguards enhancers from aberrant DNA methylation and epigenetic reprogramming in ERα-positive breast cancer cells

Lyu, R., Zhu, X., Shen, Y., Xiong, L., Liu, L., Liu, H., Wu, F., Argueta, C. E., & Tan, L. (2021) · Epigenetics · doi:10.1080/15592294.2021.1997405 · Cited by 14

DNMT3A and TET2 mutations reshape hematopoiesis in opposing ways

López-Moyado, I. F., & Rao, A. (2020) · Nature Genetics · doi:10.1038/s41588-020-0641-2 · Cited by 12

On correlative and causal links of replicative epimutations

Zhou, W., & Reizel, Y. (2024) · Trends in Genetics · doi:10.1016/j.tig.2024.08.008 · Cited by 13

Clinical Insights into the Management of Blastic Plasmacytoid Dendritic Cell Neoplasm

Zhang, Y., & Sokol, L. (2022) · Cancer Management and Research · doi:10.2147/cmar.s330398 · Cited by 11

The Potential Equivalents of TET2 Mutations

Paşca, S., Jurj, A. M., Zdrenghea, M., & Tomuleasa, C. (2021) · Cancers · doi:10.3390/cancers13071499 · Cited by 10

Oncogenic Enhancers in Leukemia

Mulet‐Lazaro, R., & Delwel, R. (2024) · Blood Cancer Discovery · doi:10.1158/2643-3230.bcd-23-0211 · Cited by 11

Epigenetic Modulation of Self-Renewal Capacity of Leukemic Stem Cells and Implications for Chemotherapy

Momparler, R. L., Côté, S., & Momparler, L. F. (2020) · Epigenomes · doi:10.3390/epigenomes4010003 · Cited by 10

SFXN3 is Associated with Poor Clinical Outcomes and Sensitivity to the Hypomethylating Therapy in Non-M3 Acute Myeloid Leukemia Patients

Dong, Y., Jin, F., Wang, J., Li, Q., Huang, Z., Xia, L., & Yang, M. (2023) · Current Gene Therapy · doi:10.2174/1566523223666230724121515 · Cited by 11

Emerging DNA Methylome Targets in FLT3-ITD-Positive Acute Myeloid Leukemia: Combination Therapy with Clinically Approved FLT3 Inhibitors

Tecik, M., & Adan, A. (2024) · Current Treatment Options in Oncology · doi:10.1007/s11864-024-01202-7 · Cited by 9

Transcriptional variability accelerates preleukemia by cell diversification and perturbation of protein synthesis

Gupta, S., Dovey, O. M., Domingues, A. F., Cyran, O. W., Cash, C. M., Giotopoulos, G., Rak, J. M., Cooper, J. L., Gozdecka, M., Dijkhuis, L., et al. (2022) · Science Advances · doi:10.1126/sciadv.abn4886 · Cited by 10

The prognostic role of C-KIT, TET1 and TET2 gene expression in Acute Myeloid Leukemia

Nabil, R., Hassan, N. M., Abdellateif, M. S., Gawdat, R. M., & Elshazly, S. S. (2022) · Molecular Biology Reports · doi:10.1007/s11033-022-08000-0 · Cited by 9

Noncoding rules of survival: epigenetic regulation of normal and malignant hematopoiesis

Wallace, L. M., & Obeng, E. A. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1273046 · Cited by 11

Epigenetic Control of the Vasopressin Promoter Explains Physiological Ability to Regulate Vasopressin Transcription in Dehydration and Salt Loading States in the Rat

Greenwood, M. P., Greenwood, M., Gillard, B. T., Loh, S., Paton, J. F. R., & Murphy, D. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12371 · Cited by 9

TET2 Mutation and High miR-22 Expression as Biomarkers to Predict Clinical Outcome in Myelodysplastic Syndrome Patients Treated with Hypomethylating Therapy

Yun, J., Ji, Y. S., Jang, G. H., Lim, S. H., Kim, S. H., Kim, C. K., Bae, S. B., Won, J.-H., & Park, S. K. (2021) · Current Issues in Molecular Biology · doi:10.3390/cimb43020065 · Cited by 9

Super-Enhancers Dysregulations in Hematological Malignancies

Belloucif, Y., & Lobry, C. (2022) · Cells · doi:10.3390/cells11020196 · Cited by 10

TET2 binding to enhancers facilitates transcription factor recruitment in hematopoietic cellsPreprint

Rasmussen, K. D., Berest, I., Kessler, S., Nishimura, K., Simón-Carrasco, L., Vassilou, G. S., Pedersen, M. T., Christensen, J. F., Zaugg, J. B., & Helin, K. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/336008 · Cited by 10

Deficiency of T follicular helper cell Tet3 DNA demethylation inhibits pathogenic IgG2c class switching and chronic GVHD

Zaiken, M. C., Jin, S., McDonald-Hyman, C. S., Hartigan, C. R., Sage, P. T., Hippen, K. L., Koehn, B. H., Panoskaltsis‐Mortari, A., Riddle, M. J., Eide, C. R., et al. (2025) · Blood · doi:10.1182/blood.2024025036 · Cited by 8

Neomorphic leukemia-derived mutations in the TET2 enzyme induce genome instability via a substrate shift from 5-methylcytosine to thymine

Jin, G.-B., Rong, S., Yin, D., Deng, Z.-H., Ding, X. L., Sheng, M., Gao, H. F., Kohli, R. M., Xu, G., & Zhou, D. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2418318122 · Cited by 8

TET2 regulates immune tolerance in chronically activated mast cells

Rigo, R., Chelbi, R., Agopian, J., Letard, S., Griffon, A., Ghamlouch, H., Vernerey, J., Ladopoulos, V., Voisset, E., Sepulveda, P. D., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.154191 · Cited by 8

A Pre-Leukemic DNA Methylation Signature in Healthy Individuals at Higher Risk for Developing Myeloid Malignancy

Lao, Z., Ding, L., Sun, Q.-Y., Li, J., Yan, B., Ng, A. Y. J., Capinpin, S. M., Wang, R., Li, Y., Chng, W. J., et al. (2024) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-22-3804 · Cited by 7

Epigenetic modifications in hematopoietic ecosystem: a key tuner from homeostasis to acute myeloid leukemia

Yao, S., Guo, R., Tian, W., Zheng, Y., Hu, J. J., Han, G., Yin, R., Zhou, F., & Zhang, H. (2024) · Blood Science · doi:10.1097/bs9.0000000000000206 · Cited by 7

RNA splicing factor Rbm25 underlies heterogeneous preleukemic clonal expansion in mice

Bramlett, C. S., Eerdeng, J., Du, J., Lee, Y., Garcia, I., Vergel-Rodriguez, M., Condie, P., Nogalska, A., & Lu, R. (2023) · Blood · doi:10.1182/blood.2023019620 · Cited by 8

5-Azacytidine Transiently Restores Dysregulated Erythroid Differentiation Gene Expression in TET2-Deficient Erythroleukemia Cells

Reilly, B. M., Luger, T., Park, S., Lio, C. J., González‐Avalos, E., Wheeler, E. C., Lee, M., Williamson, L. M., Tanaka, T. N., Diep, D. H., et al. (2020) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-20-0453 · Cited by 7

Divergent molecular pathways drive monomorphic epitheliotropic and enteropathy-associated intestinal T-cell lymphoma

Vallois, D., Missiaglia, E., Veloza, L. C., Fischer, A., Cavalieri, D., Rattina, V., Bisig, B., Roh, V., Wiehle, L., Sarkis, R., et al. (2025) · Leukemia · doi:10.1038/s41375-025-02777-2 · Cited by 7

TET2 rs2454206, TET2 rs12498609 and ASXL1 rs3746609 single nucleotide polymorphisms in patients with myelodysplastic syndromes

Hu, J., Xu, J., Tian, T., Xie, J., Fan, L., Zhu, G., Xia, T., Chen, X., Tan, Y., Chen, X., et al. (2018) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2018.11.002 · Cited by 6

Genome-wide differential DNA methylation analysis of MDA-MB-231 breast cancer cells treated with curcumin derivatives, ST08 and ST09

Nirgude, S., Desai, S. S., & Choudhary, B. (2022) · BMC Genomics · doi:10.1186/s12864-022-09041-2 · Cited by 6

Clonal haematopoiesis - a novel entity that modifies pathological processes in elderly

Belotserkovskaya, E., Golotin, V., Uyanik, B., & Demidov, O. N. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01590-z · Cited by 8

Cooperative progression of colitis and leukemia modulated by clonal hematopoiesis via PTX3/IL-1β pro-inflammatory signaling

He, H., Wen, Y., Yu, H., Liu, J., Huo, Q., Jin, W., Wang, Z., Du, G., Du, J., Wang, H., et al. (2024) · Genes & Diseases · doi:10.1016/j.gendis.2024.101397 · Cited by 5

Novel therapies in myelodysplastic syndromes

Swoboda, D. M., Gesiotto, Q., & Sallman, D. A. (2020) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000562 · Cited by 7

SERS-Based Assessment of MRD in Acute Promyelocytic Leukemia?

Turcas, C., Moisoiu, V., Ştefancu, A., Jurj, A. M., Iancu, Ș. D., Teodorescu, P., Paşca, S., Bojan, A. S., Trifa, A. P., Iluta, S., et al. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01024 · Cited by 6

High-Resolution Analysis of 5-Hydroxymethylcytosine by TET-Assisted Bisulfite Sequencing

Huang, Z., Meng, Y., Szabó, P. E., Kohli, R. M., & Pfeifer, G. P. (2020) · Methods in molecular biology · doi:10.1007/978-1-0716-0876-0_25 · Cited by 6

PROSER1 modulates DNA demethylation through dual mechanisms to prevent syndromic developmental malformationsPreprint

Fleming, A., Knatko, E. V., Li, X., Zoch, A., Heckhausen, Z., Stransky, S., Brenes, A. J., Sidoli, S., Hájková, P., O’Carroll, D., et al. (2024) · Genes & Development · doi:10.1101/gad.352176.124 · Cited by 5

Somatic mutations and DNA methylation identify a subgroup of poor prognosis within lower‐risk myelodysplastic syndromes

Rombaut, D., Sandmann, S., Tekath, T., Crouch, S., de Graaf, A. O., Smith, A. G., Painter, D., Kosmider, O., Tobiasson, M., Lennartsson, A., et al. (2025) · HemaSphere · doi:10.1002/hem3.70073 · Cited by 6

Dynamics and Function of DNA Methylation During Development

Lennartsson, A. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803395-1.00003-4 · Cited by 5

TET2 deficiency cooperates with CBFB‐MYH11 to induce acute myeloid leukaemia and represents an early leukaemogenic event

Reckzeh, K., Estruch, M., Ali, M., Helbo, A. S., Mosbech, A., Won, K., Rücker, F. G., Döhner, K., & Theilgaard‐Mönch, K. (2022) · British Journal of Haematology · doi:10.1111/bjh.18027 · Cited by 5

Epigenetic-modifying agents: The potential game changers in the treatment of hematologic malignancies

Hojjatipour, T., Ajeli, M., Maali, A., & Azad, M. (2024) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2024.104498 · Cited by 5

Mutation-Driven Therapy in MDS

Swoboda, D. M., & Sallman, D. A. (2019) · Current Hematologic Malignancy Reports · doi:10.1007/s11899-019-00554-4 · Cited by 5

TET2-Mediated mRNA and DNA Oxidation in Leukemia Homing and Immune Evasion

Li, Y., Deng, X., Dong, L., Han, L., Nguyen, L. X. T., Xue, J., Zhao, Z., Li, W., Qing, Y., Shen, C., et al. (2022) · Blood · doi:10.1182/blood-2022-162619

PU.1-Dependent Enhancer Inhibition Separates Tet2 -Deficient Hematopoiesis from Malignant Transformation

Aivalioti, M. M., Bartholdy, B. A., Pradhan, K., Bhagat, T. D., Zintiridou, A., Jeong, J. J., Thiruthuvanathan, V. J., Pujato, M., Paranjpe, A., Zhang, C., et al. (2022) · Blood Cancer Discovery · doi:10.1158/2643-3230.bcd-21-0226 · Cited by 22

Lower Levels of TET2 Gene Expression, with a Higher Level of TET2 Promoter Methylation in Patients with AML; Evidence for the Role of Aberrant Methylation in AML Pathogenesis

Ghasemi, B., Ahmadi, J., Zaker, F., Tabatabaei, T., Kiani-Zadeh, M., & Kazemi, A. (2023) · Indian Journal of Hematology and Blood Transfusion · doi:10.1007/s12288-023-01673-y · Cited by 2

Loss Of Tet2 Collaborates With AML1-ETO In Inducing Leukemogenesis

Rasmussen, K. D., Jia, G., Johansen, J. V., Bernard, O., & Helin, K. (2013) · Blood · doi:10.1182/blood.v122.21.1251.1251

TET2 Mutations Affect Non-CpG Island DNA Methylation at Enhancers and Transcription Factor–Binding Sites in Chronic Myelomonocytic Leukemia

Yamazaki, J., Jelı́nek, J., Lu, Y., Cesaroni, M., Madžo, J., Neumann, F., He, R. L., Taby, R. F., Vasanthakumar, A., Macrae, T. A., et al. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-0739 · Cited by 90