The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Fibroblast growth factor signaling in skeletal development and disease
Open accessAbstract
Fibroblast growth factor (FGF) signaling pathways are essential regulators of vertebrate skeletal development. FGF signaling regulates development of the limb bud and formation of the mesenchymal condensation and has key roles in regulating chondrogenesis, osteogenesis, and bone and mineral homeostasis. This review updates our review on FGFs in skeletal development published in Genes & Development in 2002, examines progress made on understanding the functions of the FGF signaling pathway during critical stages of skeletogenesis, and explores the mechanisms by which mutations in FGF signaling molecules cause skeletal malformations in humans. Links between FGF signaling pathways and other interacting pathways that are critical for skeletal development and could be exploited to treat genetic diseases and repair bone are also explored.
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Cites
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Disruption of the fibroblast growth factor-2 gene results in decreased bone mass and bone formation
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“Mice lacking Fgf2 display reduced bone formation due to decreased osteoblast differentiation (Montero et al. 2000; Xiao et al. 2010).”
BackgroundThe Cbl interactome and its functions
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Early onset of craniosynostosis in an Apert mouse model reveals critical features of this pathology
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“Fgfr3 expression in proliferating chondrocytes requires Sox9, and Sox9-binding sites are found in the Fgfr3 gene (Oh et al. 2014).”
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Cited by
Blood vessel formation and function in bone
Sivaraj, K. K., & Adams, R. H. (2016) · Development · doi:10.1242/dev.136861 · Cited by 441
FDA-approved bone grafts and bone graft substitute devices in bone regeneration
Gillman, C. E., & Jayasuriya, A. C. (2021) · Materials Science and Engineering: C · doi:10.1016/j.msec.2021.112466 · Cited by 417
The Role of Fibroblast Growth Factor (FGF) Signaling in Tissue Repair and Regeneration
Farooq, M., Khan, A. W., Kim, M. S., & Choi, S. (2021) · Cells · doi:10.3390/cells10113242 · Cited by 346
Fibroblast growth factors: key players in regeneration and tissue repair.
Maddaluno, L., Urwyler, C., & Werner, S. (2017) · Development · doi:10.1242/dev.152587 · Cited by 241
The cartilage extracellular matrix as a transient developmental scaffold for growth plate maturation
Melrose, J., Shu, C., Whitelock, J. M., & Lord, M. S. (2016) · Matrix Biology · doi:10.1016/j.matbio.2016.01.008 · Cited by 96
Metadata
- Authors
- Ornitz, D. M., & Marie, P. J.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2015-07-15
- Volume
- 29
- Issue
- 14
- Pages
- 1463-1486
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2136970568
- Cited by
- 418
- References
- 9
- Type
- posted content
- Language
- en
- Open access
- diamond
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
