The DOI matches its Crossref record; 227 of the 227 references it cites were found in a registry or an index.
Melanoma plasticity and phenotypic diversity: therapeutic barriers and opportunities
Open accessAbstract
An incomplete view of the mechanisms that drive metastasis, the primary cause of cancer-related death, has been a major barrier to development of effective therapeutics and prognostic diagnostics. Increasing evidence indicates that the interplay between microenvironment, genetic lesions, and cellular plasticity drives the metastatic cascade and resistance to therapies. Here, using melanoma as a model, we outline the diversity and trajectories of cell states during metastatic dissemination and therapy exposure, and highlight how understanding the magnitude and dynamics of nongenetic reprogramming in space and time at single-cell resolution can be exploited to develop therapeutic strategies that capitalize on nongenetic tumor evolution.
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Cites
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Self-citationBRAF — a tumour-agnostic drug target with lineage-specific dependencies
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Self-citationActin dynamics during tumor cell dissemination
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Metadata
- Authors
- Rambow, F., Marine, J.-C., & Goding, C. R.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2019-10-01
- Volume
- 33
- Issue
- 19-20
- Pages
- 1295-1318
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2978972173
- Cited by
- 325
- References
- 227
- Type
- posted content
- Language
- en
- Open access
- diamond
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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