The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Canalization of auxin flow by Aux/IAA-ARF-dependent feedback regulation of PIN polarity
Open accessAbstract
Plant development is characterized by a profound ability to regenerate and form tissues with new axes of polarity. An unsolved question concerns how the position within a tissue and cues from neighboring cells are integrated to specify the polarity of individual cells. The canalization hypothesis proposes a feedback effect of the phytohormone auxin on the directionality of intercellular auxin flow as a means to polarize tissues. Here we identify a cellular and molecular mechanism for canalization. Local auxin application, wounding, or auxin accumulation during de novo organ formation lead to rearrangements in the subcellular polar localization of PIN auxin transport components. This auxin effect on PIN polarity is cell-specific, does not depend on PIN transcription, and involves the Aux/IAA-ARF (indole-3-acetic acid-auxin response factor) signaling pathway. Our data suggest that auxin acts as polarizing cue, which links individual cell polarity with tissue and organ polarity through control of PIN polar targeting. This feedback regulation provides a conceptual framework for polarization during multiple regenerative and patterning processes in plants.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“the expression of PIN proteins precedes vascular development (Sauer et al., 2006; Scarpella et al., 2006; Wenzel et al., 2007)”
From Shaping plant architecture (2015) · cites this paper as Sauer et al., 2006
Citations
Cites
Local, Efflux-Dependent Auxin Gradients as a Common Module for Plant Organ Formation
Benková, E., Michniewicz, M., Sauer, M., Teichmann, T., Seifertová, D., Jürgens, G., & Friml, J. (2003) · Cell · doi:10.1016/s0092-8674(03)00924-3 · Cited by 2,637
Self-citationAuxin: Regulation, Action, and Interaction
Woodward, A. W. (2005) · Annals of Botany · doi:10.1093/aob/mci083 · Cited by 2,399
The F-box protein TIR1 is an auxin receptor
Dharmasiri, N., Dharmasiri, S., & Estelle, M. (2005) · Nature · doi:10.1038/nature03543 · Cited by 2,083
The PIN auxin efflux facilitator network controls growth and patterning in Arabidopsis roots
Blilou, I., Xu, J., Wildwater, M., Willemsen, V., Paponov, I. A., Friml, J., Heidstra, R., Aida, M., Palme, K. J., & Scheres, B. (2005) · Nature · doi:10.1038/nature03184 · Cited by 2,061
Self-citationEfflux-dependent auxin gradients establish the apical–basal axis of Arabidopsis
Friml, J., Vieten, A., Sauer, M., Weijers, D., Schwarz, H., Hamann, T., Offringa, R., & Jürgens, G. (2003) · Nature · doi:10.1038/nature02085 · Cited by 1,896
Self-citationThe Arabidopsis F-box protein TIR1 is an auxin receptor
Kepinski, S., & Leyser, O. (2005) · Nature · doi:10.1038/nature03542 · Cited by 1,703
Regulation of phyllotaxis by polar auxin transport
Reinhardt, D., Pesce, E.-R., Stieger, P., Mandel, T., Baltensperger, K., Bennett, M., Traas, J., Friml, J., & Kuhlemeier, C. (2003) · Nature · doi:10.1038/nature02081 · Cited by 1,523
Self-citationSteeves, T. A., & Sussex, I. M. (1989) · doi:10.1017/cbo9780511626227 · Cited by 1,334
Auxin transport inhibitors block PIN1 cycling and vesicle trafficking
Geldner, N., Friml, J., Stierhof, Y.-D., Jürgens, G., & Palme, K. J. (2001) · Nature · doi:10.1038/35096571 · Cited by 1,244
Self-citationHeisler, M. G., Ohno, C., Das, P., Sieber, P., Reddy, G. V., Long, J. A., & Meyerowitz, E. M. (2005) · Current Biology · doi:10.1016/j.cub.2005.09.052 · Cited by 1,189
Cited by
Sorted by citations
Items 401–453 of 453
Morphological and genetic characterization of the leafy head of Chinese cabbage (Brassica rapa)
Sun, X. X. (2018) · doi:10.18174/457901 · Cited by 1
顾, 铭., 方, 云., 李, 生., 周, 勇., 朱, 金., 梁, 国., & 顾, 飞. (2010) · Chinese Science Bulletin (Chinese Version) · doi:10.1360/csb2010-55-13-1240 · Cited by 1
Auxin transport and actinorhizal nodule development in the tropical tree Casuarina glauca
Péret, B., & LAPLAZE, L. (2007) · OpenGrey (Institut de l'Information Scientifique et Technique) · Cited by 1
Plant hormones in wood formation
Björklund, S. (2007) · Epsilon Open Archive (Sveriges lantbruksuniversitet biblioteket (Swedish University of Agricultural Sciences)) · Cited by 1
Wiśniewska, J., Pietrzykowska, M., Szyndel, B., & Tretyn, A. (2009) · Zeszyty Problemowe Postępów Nauk Rolniczych
Self-citationGenomics of Auxin Action in Roots
Williams, E. L., & Smet, I. D. (2012) · Wiley eBooks · doi:10.1002/9781118447093.ch3
Identification and characterisation of Arabidopsis ER accessory proteins
Ferguson, A. (2012) · Nottingham ePrints (University of Nottingham)
Zsuzsanna, K. (2009) · SZTE Repository of Dissertations (University of Szeged)
Bohn-Courseau, I., & Traas, J. A. (2007) · Wiley eBooks · doi:10.1002/9780470015902.a0020116
Intra-panicle Variation in Seed Shapes of Weedy Rice
Apuan, D. A., Torres, M. A., Gorospe, J. G., Amparado, R. F., & Demayo, C. G. (2011) · AUSTRALIAN JOURNAL OF BASIC AND APPLIED SCIENCES
Update on PIN Polar Targeting PIN Polar Targeting 1
Feraru, E. (2008)
Natural roles and applications in dissecting auxin gene regulation pathways
Ckurshumova, W., Krogan, N. T., Marcos, D., Caragea, A. E., & Berleth, T. (2012)
Quantifying Vein Patterns in Growing Leaves
Assaf, R. (2011) · uO Research (University of Ottawa) · doi:10.20381/ruor-4591
Roles of auxin response factors in Arabidopsis flower development
Wu, M. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/5f8g-yt75
Signaling and Genetic Regulation of the Plant Stem Cells
Pavlović, M. D., & Radotić, K. (2017) · Springer eBooks · doi:10.1007/978-3-319-47763-3_24
actinorhizien chez l'arbre tropical Casuarina glauca
Benjamin, P. (2007)
Investigations into cell polarity and trafficking in the plant model Arabidopsis thaliana
Adamowski, M. (2018) · Institute of Science and Technology Austria · doi:10.15479/at:ista:th_842
Transcriptional Regulation of Gene Expression at Early Stages of Arabidopsis Vein Development
Gardiner, J. (2016) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3319s99f
Haaning, A. (2018) · University of Minnesota Digital Conservancy (University of Minnesota)
Unraveling the regulation of plant vascular identity
Smit, M. E. (2019) · doi:10.18174/476094
Identifying auxin response factor genes and their co‐expression networks in Medicago truncatula
Burks, D. J., & Azad, R. K. (2019) · The Model Legume Medicago truncatula · doi:10.1002/9781119409144.ch98
Deslauriers, S. D., & Spalding, E. P. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.01.25.428116
Dzhamieiev, V. Y. (2021) · Vìsnik Harkìvsʹkogo nacìonalʹnogo agrarnogo unìversitetu Serìâ Bìologiâ · doi:10.35550/vbio2021.03.098
Lu, Q., Zhang, Y., Hellner, J., Xu, X., Pauwels, J., Giannini, C., Ma, Q., Dejonghe, W., Han, H., van de Cotte, B., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.12.14.472597
Self-citationChamovitz, A. D., & Jander, G. (2012) · doi:10.32747/2012.7597917.bard
Fletcher, J. C. (2007) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.1067751.520668
Hormonal and genetic control of leaf and vein development in maize
Robil, J. L. (2022) · MOspace Institutional Repository (University of Missouri) · doi:10.32469/10355/94094
Li, H., Guo, T., Liu, E., Li, N., Li, P., Sun, Y., Liu, Y., Zhang, Q., Sang, Y., & Mu, C. (2022) · Russian Journal of Plant Physiology · doi:10.1134/s1021443722601197
Çeti̇n, E. S. (2024) · Scientia Agricola · doi:10.1590/1678-992x-2023-0207
Ren, K., Su, Y., Tang, T., Kong, W., Yang, Y., Zhao, X., & Cheng, H. (2024) · Journal of the American Society for Horticultural Science · doi:10.21273/jashs05393-24
Singh, S., Sharma, K., & Kumar, M. S. (2024) · Plant Cell Tissue and Organ Culture (PCTOC) · doi:10.1007/s11240-024-02868-5
(2024) · Elsevier eBooks · doi:10.1016/b978-0-443-22159-0.16001-7
Diverse Roles of Strigolactones in Plant Growth and Development
Hussain, A., Wani, K. I., & Faizan, S. (2025) · Wiley eBooks · doi:10.1002/9781394302826.ch4
TOW links TIR1/AFB-mediated signalling with Receptor-Like Kinases in auxin canalizationPreprint
Li, M., Rýdza, N., Mazur, E., Molnár, G., Nodzyński, T., & Friml, J. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.25.650570
Self-citationNahas, Z., Bridgen, A. J., Loman, T. E., Dillon, J., Abley, K., Cano‐Ramirez, D. L., Ticchiarelli, F., Seale, M., Locke, J. C. W., & Leyser, O. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.26.656108
MAKR6 integrates TMK and CAMEL/CANAR signalling for auxin canalization in ArabidopsisPreprint
Ge, Z., Koczka, L., Mazur, E., Molnár, G., Vladimirtsev, D., Kassem, N., Ikene, S. A., Fiedler, L., & Friml, J. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.07.680881
Self-citationExploring the role of BpPIN3 in hormonal regulation and branching morphogenesis of Betula pendula
Chen, K., Xu, Z., Ge, B., Liu, Z., Xie, Y., Ji, J., Zhang, X., & Jiang, J. (2025) · BMC Plant Biology · doi:10.1186/s12870-025-07771-5
Kiefer, C. S. (2014) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
Hexuan, W., Zhang, X., Yang, G., Jia, X., Gao, J., Wang, H., jiang, J., Li, J., Zhang, H., Xu, X., et al. (2025) · Journal of Integrative Agriculture · doi:10.1016/j.jia.2025.12.045
Translating Arabidopsis - based insights into gravitropic set-point angle regulation in monocots
Choudhary, S., & Retzer, K. (2026) · Journal of Experimental Botany · doi:10.1093/jxb/erag027
Schneider, A. (2020) · theses.fr (ABES) · doi:10.70675/3a64f17eze0d5z4c45zabc2z96a2e3eec1a6
A front propagation model of leaf growth
Scao, C. L. (2024) · theses.fr (ABES) · doi:10.70675/05fa1f88zde47z439fz86a5z3f2b0b390f67
The radial step of microtubules as a pre-preprophase band structure in plant cell division
Melogno, I. (2024) · theses.fr (ABES) · doi:10.70675/189739e4z5c92z479dz8f92zebe3767573e3
Jin, L., Wang, Y., Du, W., Temuqile, & Gao, F. (2026) · Gene Reports · doi:10.1016/j.genrep.2026.102529
Guo, X., Kumar, A., Johansen, I. E., Harholt, J., Willats, W. G. T., Ulvskov, P., & Mravec, J. (2026) · Plant Molecular Biology · doi:10.1007/s11103-026-01759-x
Pasternak, T. P., & Paponov, I. A. (2026) · Plant Science · doi:10.1016/j.plantsci.2026.113492
MAKR6 integrates TMK and CAMEL/CANAR signalling for auxin canalization in Arabidopsis
Ge, Z., Koczka, L., Mazur, E., Molnár, G., Vladimirtsev, D., Kassem, N., Ikene, S. A., Fiedler, L., & Friml, J. (2026) · Nature Plants · doi:10.1038/s41477-026-02435-0
Self-citation
Metadata
- Authors
- Sauer, M., Balla, J., Luschnig, C., Wiśniewska, J., Reinöhl, V., Friml, J., & Benková, E.
- Affiliations
- University of Tübingen (DE)
- Mendel University in Brno (CZ)
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2006-10-15
- Volume
- 20
- Issue
- 20
- Pages
- 2902-2911
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- PMC
- PMC1619939
- OpenAlex
- W2105722863
- Cited by
- 453
- References
- 45
- Citations by year
- 2026: 8 · 2025: 13 · 2024: 15 · 2023: 10 · 2022: 20 · 2021: 25 · 2020: 22 · 2019: 19 · 2018: 22 · 2017: 15 · 2016: 26 · 2015: 21 · 2014: 33 · 2013: 37 · 2012: 28
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Volkswagen Foundation
- Grantová Agentura České Republiky
- Fundacja na rzecz Nauki Polskiej
- Austrian Science Fund
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Parasitism and Resistance
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant nutrient uptake and metabolism
- Keywords
- auxin transport, PIN auxin efflux carriers, canalization, auxin response factor, auxin response, cell polarity, tissue polarity, wounding, organ formation, plant regeneration, feedback regulation
- MeSH terms
- Indoleacetic Acids, Plant Growth Regulators, Plant Proteins, Transcription, Genetic, Signal Transduction, Arabidopsis, Gene Expression Regulation, Plant, Plant Roots, Plant Physiological Phenomena, Phototropism, Pisum sativum, Arabidopsis Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review