The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
The establishment of neuronal properties is controlled by Sox4 and Sox11
Open accessAbstract
The progression of neurogenesis relies on proneural basic helix–loop–helix (bHLH) transcription factors. These factors operate in undifferentiated neural stem cells and induce cell cycle exit and the initiation of a neurogenic program. However, the transient expression of proneural bHLH proteins in neural progenitors indicates that expression of neuronal traits must rely on previously unexplored mechanisms operating downstream from proneural bHLH proteins. Here we show that the HMG-box transcription factors Sox4 and Sox11 are of critical importance, downstream from proneural bHLH proteins, for the establishment of pan-neuronal protein expression. Examination of a neuronal gene promoter reveals that Sox4 and Sox11 exert their functions as transcriptional activators. Interestingly, the capacity of Sox4 and Sox11 to induce the expression of neuronal traits is independent of mechanisms regulating the exit of neural progenitors from the cell cycle. The transcriptional repressor protein REST/NRSF has been demonstrated to block neuronal gene expression in undifferentiated neural cells. We now show that REST/NRSF restricts the expression of Sox4 and Sox11, explaining how REST/NRSF can prevent precocious expression of neuronal proteins. Together, these findings demonstrate a central regulatory role of Sox4 and Sox11 during neuronal maturation and mechanistically separate cell cycle withdrawal from the establishment of neuronal properties.
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Cites
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Liu, M.-L., Zang, T., Zou, Y., Chang, J. C., Gibson, J. R., Huber, K. M., & Zhang, C.-L. (2013) · Nature Communications · doi:10.1038/ncomms3183 · Cited by 343
Beckervordersandforth, R., Tripathi, P., Ninkovic, J., Bayam, E., Lepier, A., Stempfhuber, B., Kirchhoff, F., Hirrlinger, J., Haslinger, A., Lie, D. C., et al. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.11.017 · Cited by 335
Spatial and temporal specification of neural fates by transcription factor codes
Guillemot, F. (2007) · Development · doi:10.1242/dev.006379 · Cited by 308
HDAC8: a multifaceted target for therapeutic interventions
Chakrabarti, A., Oehme, I., Witt, O., Oliveira, G., Sippl, W., Romier, C., Pierce, R. J., & Jung, M. (2015) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2015.04.013 · Cited by 284
Cis-regulatory control of corticospinal system development and evolution
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Metadata
- Authors
- Bergsland, M., Werme, M., Malewicz, M., Perlmann, T., & Muhr, J.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2006-12-15
- Volume
- 20
- Issue
- 24
- Pages
- 3475-3486
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2129282939
- Cited by
- 339
- References
- 57
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Bergsland, M., Werme, M., Malewicz, M., Perlmann, T., & Muhr, J. (2006). The establishment of neuronal properties is controlled by Sox4 and Sox11. Genes & Development. https://doi.org/10.1101/gad.403406
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